scholarly journals Subarachnoid blood acutely induces spreading depolarizations and early cortical infarction

Brain ◽  
2017 ◽  
Vol 140 (10) ◽  
pp. 2673-2690 ◽  
Author(s):  
Jed A Hartings ◽  
Jonathan York ◽  
Christopher P Carroll ◽  
Jason M Hinzman ◽  
Eric Mahoney ◽  
...  
Keyword(s):  
Cortical Infarction ◽  
Subarachnoid Blood

CT and Angiographic Analysis of Posterior Communicating Artery Aneurysms: What Factors Influence the Amount of Subarachnoid Blood?

1998 ◽  
Vol 39 (3) ◽  
pp. 441
Author(s):  
Young Min Kim ◽  
Kun Sik Jung ◽  
Myung Ho Rho ◽  
Pil Youb Choi ◽  
Young Soon Sung ◽  
...  
Keyword(s):  
Posterior Communicating Artery ◽  
Subarachnoid Blood

Evaluation of prostaglandin biosynthetic activity in canine basilar artery following subarachnoid injection of blood

1981 ◽  
Vol 55 (5) ◽  
pp. 771-778 ◽  
Author(s):  
Tomio Sasaki ◽  
Sei-itsu Murota ◽  
Susumu Wakai ◽  
Takao Asano ◽  
Keiji Sano
Keyword(s):  
Arachidonic Acid ◽  
Platelet Aggregation ◽  
Cerebral Artery ◽  
Basilar Artery ◽  
Biosynthetic Activity ◽  
Content Type ◽  
Blood Injection ◽  
Canine Basilar Artery ◽  
Subarachnoid Blood ◽  
Fine Print

✓ Transformation of arachidonic acid into prostaglandins was investigated in the basilar artery by incubating sections of artery with carbon-14-labeled arachidonic acid. Thin-layer radiochromatography revealed that, in normal canine basilar arteries, 14C-arachidonic acid was transformed mainly to 6-ketoprostaglandin (PG)F1α, a spontaneous metabolite of prostacyclin (PGI2). Among other prostaglandins, only a small amount of PGF2α was detected, whereas PGD2, PGE2, and thromboxane B2 were not. Arteries removed on Days 3 and 8 after subarachnoid blood injection showed a prostaglandin synthesis profile similar to that in the normal cerebral artery. In borate-buffered saline (0.1M borate buffer, pH 9.0/0.15M NaCl = 1:9, vol/vol), canine basilar artery produced a PGI2-like substance that inhibited adenosine diphosphate (ADP)-induced platelet aggregation. Its anti-aggregatory activity was completely abolished by acidification. Aspirin likewise inhibited production of the anti-aggregatory substance. From these results, it was concluded that the anti-aggregatory activity was due solely to the production of PGI2 by the arterial specimen. Based on the above results, PGI2 biosynthetic activity in the cerebral artery exposed to subarachnoid blood injection was bioassayed by measuring the inhibitory activity of the incubation product upon ADP-induced platelet aggregation following incubation of the arteries in borate-buffered saline for 5 to 30 minutes at 20°C, using synthetic PGI2-Na as a standard. The synthetic activity of PGI2 in the artery exposed to subarachnoid blood injection had diminished remarkably by Days 3 and 8. This diminution of PGI2 synthesis in the cerebral artery may be involved in the pathogenesis of cerebral vasospasm.

Prevention of cerebral vasospasm after SAH with a thromboxane synthetase inhibitor, OKY-1581

1982 ◽  
Vol 57 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Tomio Sasaki ◽  
Susumu Wakai ◽  
Takao Asano ◽  
Kintomo Takakura ◽  
Keiji Sano
Keyword(s):  
Cerebral Vasospasm ◽  
Morphological Changes ◽  
Content Type ◽  
Synthetase Inhibitor ◽  
Thromboxane Synthetase Inhibitor ◽  
Thromboxane Synthetase ◽  
Basilar Arteries ◽  
Blood Injection ◽  
Subarachnoid Blood ◽  
Fine Print

✓ The efficacy of thromboxane synthetase inhibitor in the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH) was evaluated in a prolonged experiment using dogs. Changes in the diameter of the basilar artery were followed by angiography, and morphological changes were studied by photomicroscopy and electron microscopy. As a thromboxane synthetase inhibitor, OKY-1581 (sodium-(E)-3-(4(-3-pyridylmethyl)phenyl)-2-methylacrylate)was used. Dogs received intravenous injections of 160 mg of OKY-1581 dissolved in 2 ml of physiological saline immediately after subarachnoid blood injection. Subsequently, the animals received continuous intravenous infusion of the drug at the rate of 4 gm/50 ml/24 hours until sacrifice 4 days after induction of SAH. Control dogs received subarachnoid blood injection without treatment with OKY-1581. Angiographic examination revealed that the late spasm was almost completely abolished by the treatment with OKY-1581. Early spasm was also prevented, but the drug's effect was less prominent than it was on the late spasm. Morphological study revealed degenerative changes in the endothelium and myonecrotic changes in the tunica media following SAH in the basilar arteries of the treated as well as the untreated dogs. However, corrugation of the internal elastic lamina was almost completely absent in the treated dogs. The above results indicate that a disproportionate synthesis of thromboxane A2 plays an important role in the evolution of chronic cerebral vasospasm following SAH, and that drugs such as OKY-1581 that selectively inhibit thromboxane synthetase might be useful in the prevention of vasospasm.

Analysis of interobserver disagreement in the assessment of subarachnoid blood and acute hydrocephalus on CT scans

1996 ◽  
Vol 18 (6) ◽  
pp. 487-494 ◽  
Author(s):  
Elisabeth Svensson ◽  
Jan-Erik Starmark ◽  
Sven Ekholm ◽  
Claes von Essen ◽  
Anders Johansson
Keyword(s):  
Ct Scans ◽  
Acute Hydrocephalus ◽  
Subarachnoid Blood

Imaging the development of an ischemic core following photochemically induced cortical infarction in rats using Laser Speckle Contrast Analysis (LASCA)

NeuroImage ◽  
2006 ◽  
Vol 29 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Joseph S. Paul ◽  
Andreas R. Luft ◽  
Elijah Yew ◽  
Fwu-Shan Sheu
Keyword(s):  
Laser Speckle ◽  
Speckle Contrast ◽  
Cortical Infarction ◽  
Contrast Analysis ◽  
Ischemic Core ◽  
Laser Speckle Contrast Analysis

Multiple middle cerebral artery aneurysms in an infant

1990 ◽  
Vol 72 (5) ◽  
pp. 806-809 ◽  
Author(s):  
Cornelia Cedzich ◽  
J. Schramm ◽  
G. Röckelein
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Systemic Disease ◽  
Intracerebral Hematoma ◽  
Left Middle Cerebral Artery ◽  
Content Type ◽  
Middle Cerebral Artery Aneurysms ◽  
Subarachnoid Blood ◽  
Left Middle ◽  
Control Angiography

✓ An 11-month-old boy was admitted for evaluation of drowsiness, vomiting, and convulsions. Computerized tomography showed subarachnoid blood in the left sylvian fissure and a small intracerebral hematoma in the temporal lobe. Angiography revealed several aneurysms of the left middle cerebral artery (MCA). During surgery, 13 aneurysms were found arising from one main branch of the left MCA, and this segment of the MCA was trapped. Somatosensory evoked potentials did not show any change during surgery. The diseased arterial segment was examined histologically and the pathogenetic aspects of the case are discussed. Control angiography 6 months later excluded systemic disease or other aneurysms. The rarity of such lesions in childhood and their successful surgical treatment are discussed briefly.

Ruptured middle cerebral aneurysm with accumulation of subarachnoid blood within convexity arachnoid cyst

1987 ◽  
Vol 11 (4) ◽  
pp. 185-187 ◽  
Author(s):  
John R. Jinkins ◽  
Edir B. Siqueira ◽  
Abdulmoti Holoubi
Keyword(s):  
Cerebral Aneurysm ◽  
Arachnoid Cyst ◽  
Subarachnoid Blood

Subarachnoid blood and headache: Altered trigeminal tachykinin gene expression

1989 ◽  
Vol 25 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Matthew D. Linnik ◽  
Damianos E. Sakas ◽  
George R. Uhl ◽  
Michael A. Moskowitz
Keyword(s):  
Gene Expression ◽  
Subarachnoid Blood

Homolateral cerebrocortical changes in neuropeptide and receptor expression after minimal cortical infarction

Neuroscience ◽  
1995 ◽  
Vol 69 (3) ◽  
pp. 847-858 ◽  
Author(s):  
L. Van Bree ◽  
F. Zhang ◽  
S.N. Schiffmann ◽  
P. Halleux ◽  
P. Mailleux ◽  
...  
Keyword(s):  
Receptor Expression ◽  
Cortical Infarction
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