Normal acid-phosphatase and angiotensin converting enzyme activities in serum of a patient with Gaucher's disease.

1981 ◽  
Vol 27 (10) ◽  
pp. 1782-1783
Author(s):  
L B Daniels ◽  
D B Robinson ◽  
R H Glew ◽  
R F Wylin
1974 ◽  
Vol 32 (02/03) ◽  
pp. 665-669 ◽  
Author(s):  
S Yatziv ◽  
M White ◽  
A Eldor

SummaryFive platelet lysosomal enzyme activities were estimated in 22 normal individuals and in 5 patients with Gaucher’s disease: ß-D-galactosidase, N-Acetyl-ß-D-glucosa-minidase, N-Acetyl-ß-D-galactosaminidase acid-phosphatase, and ß-D-glucuronidase.In the 5 patients with Gaucher’s disease the specific activities for the first four of these enzymes were significantly higher than in normal individuals. The activity of acid-phosphatase, on the other hand, was lower in G. d. than in normals. The release of the 5 lysosomal enzymes from platelets upon incubation with thrombin was also examined in the same two groups. The only lysosomal enzyme that was not released from normal platelets was acid-phosphatase. In Gaucher’s patients, on the other hand, acid-phosphatase was invariably released from platelets when incubated with thrombin. The release of the other four enzymes from platelets of Gaucher patients was similar to that of normal controls.


Neuropeptides ◽  
1986 ◽  
Vol 8 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Maria Grazia Spillantini ◽  
Alessandro Panconesi ◽  
Pier Luigi Del Bianco ◽  
Federigo Sicuteri

1987 ◽  
Vol 33 (10) ◽  
pp. 1832-1836 ◽  
Author(s):  
Z O Echetebu ◽  
T M Cox ◽  
D W Moss

Abstract The immunological similarity between human tartrate-resistant acid phosphatase (EC 3.1.3.2) and porcine uteroferrin previously reported for the isoenzyme from spleens of patients with leukemic reticuloendotheliosis (Ketcham et al., J Biol Chem 1985;260:5768-76) has been confirmed for partly purified acid phosphatase found in the spleen of a patient with Gaucher's disease, and for the corresponding isoenzyme in other tissues and serum. Anti-uteroferrin antibodies raised in rabbits have been used to demonstrate the feasibility of their application in an immunoassay for tartrate-resistant acid phosphatase in serum.


1980 ◽  
Vol 186 (2) ◽  
pp. 605-608 ◽  
Author(s):  
P J Del Vecchio ◽  
J W Ryan ◽  
A Chung ◽  
U S Ryan

The enzymes required to convert the prohormone angiotensin I into angiotensins II and III, secretagogues of aldosterone, are enriched in association with capillary endothelium isolated from rat adrenal cortex. Thus the secretion of aldosterone may be controlled, in part, by processing of peptides occurring within the adrenal gland itself.


The Lancet ◽  
1968 ◽  
Vol 292 (7563) ◽  
pp. 358-359 ◽  
Author(s):  
G.P. Perona ◽  
C. Baccichetti ◽  
R. Tenconi

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