23Na nuclear magnetic resonance study of Na+-K+ pump inhibition by a fraction from uremic toxins.
1988 ◽
Vol 34
(10)
◽
pp. 2044-2047
◽
Keyword(s):
Abstract An in vitro inhibitor of Na+/K+-transporting ATPase (EC 3.6.1.37) was isolated from uremic plasma and normal urine by liquid chromatography. A 23Na nuclear magnetic resonance study involving living erythrocytes showed that this inhibitor causes impairment of the Na+-K+ pump of intact erythrocytes. This finding may explain the high intra-erythrocytic sodium concentration in those uremic patients exhibiting a high concentration of this inhibitor. The presence of this same inhibitor in normal urine suggests that it may play a physiological role.
1995 ◽
Vol 1272
(2)
◽
pp. 113-118
◽
2002 ◽
pp. 1302-1308
◽
1991 ◽
Vol 21
(5)
◽
pp. 589-596
◽
1971 ◽
Vol 32
(C1)
◽
pp. C1-1154-C1-1156
◽
1969 ◽
Vol 244
(20)
◽
pp. 5656-5662
1981 ◽
pp. 1082
◽