scholarly journals False-Negative Results in Detection of Monoclonal Proteins by Capillary Zone Electrophoresis: A Prospective Study

2001 ◽  
Vol 47 (8) ◽  
pp. 1477-1479 ◽  
Author(s):  
Xavier Bossuyt ◽  
Godelieve Mariën
Keyword(s):  
Prospective Study ◽  
Capillary Zone Electrophoresis ◽  
False Negative ◽  
Negative Results ◽  
False Negative Results ◽  
Zone Electrophoresis ◽  
Capillary Zone ◽  
Monoclonal Proteins ◽  
A Prospective Study

scholarly journals Prospective Study of Serum Protein Capillary Zone Electrophoresis and Immunotyping off Monoclonal Proteins by Immunosubtraction

1998 ◽  
Vol 110 (4) ◽  
pp. 503-509 ◽  
Author(s):  
Jerry A. Katzmann ◽  
Raynell Clark ◽  
Elizabeth Sanders ◽  
James P. Landers ◽  
Robert A. Kyle
Keyword(s):  
Prospective Study ◽  
Capillary Zone Electrophoresis ◽  
Serum Protein ◽  
Zone Electrophoresis ◽  
Capillary Zone ◽  
Monoclonal Proteins

scholarly journals A prospective study on inter-operator variability in semi-robotic software-based MRI/TRUS-fusion targeted prostate biopsies

2021 ◽  
Author(s):  
Fabian Derigs ◽  
Samuel Doryumu ◽  
Fabian Tollens ◽  
Dominik Nörenberg ◽  
Manuel Neuberger ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prospective Study ◽  
False Negative ◽  
Lesion Size ◽  
Negative Results ◽  
Prostate Biopsies ◽  
False Negative Results ◽  
Lesion Level ◽  
Clinically Significant ◽  
A Prospective Study

Abstract Purpose Magnetic resonance imaging (MRI)/ultrasound-fusion prostate biopsy (FB) comprises multiple steps each of which can cause alterations in targeted biopsy (TB) accuracy leading to false-negative results. The aim was to assess the inter-operator variability of software-based fusion TB by targeting the same MRI-lesions by different urologists. Methods In this prospective study, 142 patients eligible for analysis underwent software-based FB. TB of all lesions (n = 172) were carried out by two different urologists per patient (n = 31 urologists). We analyzed the number of mismatches [overall prostate cancer (PCa), clinically significant PCa (csPCa) and non-significant PCa (nsPCa)] between both performed TB per patient. In addition we evaluated factors contributing to inter-operator variability by uni- and multivariable analyses. Results In 11.6% of all MRI-lesions (10.6% of all patients) there was a mismatch between TB1 and TB2 in terms of overall prostate cancer (PCa detection. Regarding csPCa, patient-based mismatch occurred in 14.8% (n = 21). Overall PCa and csPCa detection rate of TB1 and TB2 did not differ significantly on a per-patient and per-lesion level. Analyses revealed a smaller lesion size as predictive for mismatches (OR 9.19, 95% CI 2.02–41.83, p < 0.001). Conclusion Reproducibility and precision of targeting particularly small lesions is still limited although using software-based FB. Further improvements in image-fusion, segmentation, needle-guidance, and automatization are necessary.

scholarly journals Simplified chromatographic separation of immunoglobulin M from G and its application to toxoplasma indirect immunofluorescence

1979 ◽  
Vol 9 (2) ◽  
pp. 170-174
Author(s):  
N Pyndiah ◽  
U Krech ◽  
P Price ◽  
J Wilhelm
Keyword(s):  
False Positive ◽  
False Negative ◽  
Gel Filtration ◽  
Immunoglobulin M ◽  
Antibody Technique ◽  
Negative Results ◽  
False Negative Results ◽  
A Prospective Study ◽  
Indirect Immunofluorescent ◽  
Positive Results

The indirect immunofluorescent (IIF) antibody technique for the detection of Toxoplasma gondii immunoglobulin M (IgM) often gives false negative results, probably due to the competition between IgG and IgM. We therefore adapted a gel filtration procedure for the separation of IgG and IgM to a routine diagnostic test capable handling at least 10 sera per day and requiring only 50 microliters of serum. The results from 108 sera having positive complement fixation titers for Toxoplasma showed that 17 were IgM positive when the whole serum was tested by IIF compared with 55 positive when the IgM fraction was used. Sera with antideoxyribonucleic acid titers do not give false positive results after fractionation, and the removal of IgG eliminates false positive results due to rheumatoid factor. A prospective study showed that Toxoplasma IgM may persist up to 9 months.

scholarly journals Detection of Monoclonal Proteins in Sera by Capillary Zone Electrophoresis and Free Light Chain Measurements

2002 ◽  
Vol 48 (9) ◽  
pp. 1600-1601 ◽  
Author(s):  
Godelieve Mariën ◽  
Els Oris ◽  
Arthur R Bradwell ◽  
Norbert Blanckaert ◽  
Xavier Bossuyt
Keyword(s):  
Capillary Zone Electrophoresis ◽  
Light Chain ◽  
Free Light Chain ◽  
Zone Electrophoresis ◽  
Capillary Zone ◽  
Monoclonal Proteins

Evaluation of Pressure Threshold Prior to Foot Ulceration

2001 ◽  
Vol 91 (10) ◽  
pp. 508-514 ◽  
Author(s):  
Mitchell A. Barber ◽  
Janice Conolley ◽  
Cecily M. Spaulding ◽  
A. Lee Dellon
Keyword(s):  
False Negative ◽  
Computer Assisted ◽  
Tarsal Tunnel ◽  
Axonal Loss ◽  
Negative Results ◽  
Pressure Threshold ◽  
False Negative Results ◽  
Static Touch ◽  
Tunnel Syndrome ◽  
A Prospective Study

A prospective study of 29 patients with diabetic neuropathy and 47 nondiabetic patients with tarsal tunnel syndrome were evaluated with computer-assisted neurosensory testing at three sites on the foot. The sensitivity and specificity of one-point static touch thresholds for identifying the presence of large fiber axonal loss was done using the calculated thresholds for monofilaments derived from their markings. The sensitivity for one-point static touch in identifying axonal loss was 33% for the 5.07, 38% for the 4.93, 50% for the 4.17, and 60% for the 4.08 monofilament-equivalent, with a specificity of 100% at each level. Therefore, one-point static touch testing, even using monofilaments thinner than 5.07, has a high percentage of false-negative results in identifying patients with axonal loss. (J Am Podiatr Med Assoc 91(10): 508-514, 2001)

False negative results of real time strain elastography in thyroid nodular disease

2016 ◽  
Vol 37 (S 01) ◽  
Author(s):  
D Stoian ◽  
M Craciunescu ◽  
M Craina ◽  
S Pantea ◽  
F Varcus
Keyword(s):  
Real Time ◽  
False Negative ◽  
Strain Elastography ◽  
Negative Results ◽  
False Negative Results
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