Regional blood flow and vascular resistance in the spontaneously hypertensive rat

1974 ◽  
Vol 8 (6) ◽  
pp. 758-762 ◽  
Author(s):  
A. J. TOBIA ◽  
J. Y. LEE ◽  
G. M. WALSH
Keyword(s):  
Blood Flow ◽  
Vascular Resistance ◽  
Spontaneously Hypertensive Rat ◽  
Regional Blood Flow ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

Mechanism of action of vasoconstrictor responses to atriopeptin II in conscious SHR

1985 ◽  
Vol 249 (6) ◽  
pp. R781-R786 ◽  
Author(s):  
R. W. Lappe ◽  
J. A. Todt ◽  
R. L. Wendt
Keyword(s):  
Blood Flow ◽  
Arterial Pressure ◽  
Vascular Resistance ◽  
Regional Blood Flow ◽  
Sympathetic Nerves ◽  
Spontaneously Hypertensive ◽  
Regional Vascular Resistance ◽  
6 Hydroxydopamine ◽  
Renal Vascular ◽  
Renal Sympathetic

Previous studies have demonstrated that infusion of synthetic atriopeptin II (AP II) lowered arterial pressure, reduced regional blood flow, and increased total peripheral and regional vascular resistances in conscious spontaneously hypertensive rats (SHR). This study was designed to examine the mechanism(s) involved in regional vasoconstrictor responses to AP II. In these experiments, hemodynamic actions of AP II were examined in control, 6-hydroxydopamine-treated (chemically sympathectomized), and renal-denervated groups of instrumented conscious SHR. Infusion of AP II (1 microgram X kg-1 X min-1) caused similar reductions in mean arterial pressure in control (-22 +/- 2 mmHg), chemically sympathectomized (-23 +/- 2 mmHg), and renal-denervated (-23 +/- 3 mmHg) SHR. In control SHR, AP II infusion reduced renal (-20 +/- 3%), mesenteric (-26 +/- 2%), and hindquarters (-18 +/- 10%) blood flow and increased regional vascular resistance in all three beds. Chemical sympathectomy prevented the fall in renal blood flow (RBF) and significantly abolished the regional vasoconstrictor responses to AP II infusion. In unilateral renal-denervated groups of SHR, AP II reduced renal vascular resistance (RVR) -11 +/- 3% but failed to alter RBF (-3 +/- 1%) in denervated kidneys. In contrast, RVR increased (20 +/- 7%) and RBF was significantly reduced (-29 +/- 3%) in contralateral-innervated kidneys. This study demonstrated that chemical or surgical destruction of renal sympathetic nerves abolished AP II-induced increases in RVR. These data further indicate that in conscious SHR the regional vasoconstrictor responses to AP II infusion appear to be mediated by increases in sympathetic tone rather than through direct vascular actions of AP II.

Effect of platelet activating factor (PAF) on blood flow distribution in the spontaneously hypertensive rat

Life Sciences ◽  
1984 ◽  
Vol 35 (13) ◽  
pp. 1373-1378 ◽  
Author(s):  
Brian M. Goldstein ◽  
Robert A. Gabel ◽  
Florence J. Huggins ◽  
Peter Cervoni ◽  
David L. Crandall
Keyword(s):  
Blood Flow ◽  
Spontaneously Hypertensive Rat ◽  
Platelet Activating Factor ◽  
Flow Distribution ◽  
Blood Flow Distribution ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

Olmesartan ameliorates urinary dysfunction in the spontaneously hypertensive rat via recovering bladder blood flow and decreasing oxidative stress

2013 ◽  
Vol 33 (3) ◽  
pp. 350-357 ◽  
Author(s):  
Shogo Shimizu ◽  
Motoaki Saito ◽  
Harunori Oiwa ◽  
Fumiya Ohmasa ◽  
Panagiota Tsounapi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Flow ◽  
Spontaneously Hypertensive Rat ◽  
Urinary Dysfunction ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

Regional Vascular Resistance and Haemodynamics in the Spontaneously Hypertensive Rat

1990 ◽  
Vol 15 (2) ◽  
pp. 211-217 ◽  
Author(s):  
G. Roger Thomas ◽  
Claire E. Walder ◽  
Christoph Thiemermann ◽  
John R. Vane
Keyword(s):  
Vascular Resistance ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
Regional Vascular Resistance
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