scholarly journals Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus.

Genetics ◽  
1989 ◽  
Vol 122 (3) ◽  
pp. 669-679
Author(s):  
L D Siracusa ◽  
A M Buchberg ◽  
N G Copeland ◽  
N A Jenkins
Keyword(s):  
Molecular Markers ◽  
Inbred Strain ◽  
Mouse Chromosome ◽  
Recombinant Inbred ◽  
Recombinant Inbred Strain ◽  
Interspecific Backcross ◽  
Chromosome 2 ◽  
Chromosome 4 ◽  
Agouti Locus ◽  
Mouse Chromosome 2

Abstract Recombinant inbred strain and interspecific backcross mice were used to create a molecular genetic linkage map of the distal portion of mouse chromosome 2. The orientation and distance of the Ada, Emv-13, Emv-15, Hck-1, Il-1a, Pck-1, Psp, Src-1 and Svp-1 loci from the beta 2-microglobulin locus and the agouti locus were established. Our mapping results have provided the identification of molecular markers both proximal and distal to the agouti locus. The recombinants obtained provide valuable resources for determining the direction of chromosome walking experiments designed to clone sequences at the agouti locus. Comparisons between the mouse and human genome maps suggest that the human homolog of the agouti locus resides on human chromosome 20q. Three loci not present on mouse chromosome 2 were also identified and were provisionally named Psp-2, Hck-2 and Hck-3. The Psp-2 locus maps to mouse chromosome 14. The Hck-2 locus maps near the centromere of mouse chromosome 4 and may identify the Lyn locus. The Hck-3 locus maps near the distal end of mouse chromosome 4 and may identify the Lck locus.

scholarly journals Interspecific backcross mice show sex-specific differences in allelic inheritance.

Genetics ◽  
1991 ◽  
Vol 128 (4) ◽  
pp. 813-821
Author(s):  
L D Siracusa ◽  
W G Alvord ◽  
W A Bickmore ◽  
N A Jenkins ◽  
N G Copeland
Keyword(s):  
Mouse Chromosome ◽  
Interspecific Backcross ◽  
Distal Region ◽  
Chromosome 2 ◽  
Mus Spretus ◽  
Mendelian Segregation ◽  
Transmission Frequency ◽  
Single Cross ◽  
Mouse Chromosome 2 ◽  
Transmission Distortion

Abstract Transmission distortion is identified as a difference in transmission frequency of two alleles from the normal 1:1 Mendelian segregation in diploid organisms. Transmission distortion can extend over part or all of a chromosome. The recent development of interspecific mouse backcrosses has provided a powerful method for multilocus mapping of entire chromosomes in a single cross, and consequently for identifying distortions in allelic inheritance. We used an interspecific backcross of [(C57BL/6J x Mus spretus)F1 x C57BL/6J] mice to map molecular loci to mouse chromosome 2 and had previously found that the distal region of the chromosome showed distortions in allelic inheritance. We now report the mapping of five loci (Actc-1, D2Hgu1, His-1, Hox-4.1 and Neb) to chromosome 2, which, in addition to the Abl, Ada, B2m, Bmp-2a, Hc, Emv-15, Fshb, Hck-1, Pax-1, Pck-1, Spna-2 and Vim loci previously mapped in our interspecific backcross, serve as markers to measure allelic inheritance along approximately 75% of mouse chromosome 2. Statistical analyses are used to identify and delimit chromosomal regions showing transmission distortion and to determine whether there are sex-specific differences in allelic inheritance. These studies provide evidence for sex-specific differences in allelic inheritance for chromosome 2 and suggest biological explanations for this form of transmission distortion.

Assignment of secretogranin I locus to mouse chromosome 2 by in situ hybridization and interspecific backcross analysis

Genomics ◽  
1991 ◽  
Vol 11 (2) ◽  
pp. 479-480 ◽  
Author(s):  
Nancy A. Jenkins ◽  
M.-Genevieve Mattei ◽  
Debra J. Gilbert ◽  
Christian G. Linard ◽  
Majambu Mbikay ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Mouse Chromosome ◽  
Interspecific Backcross ◽  
Chromosome 2 ◽  
Mouse Chromosome 2 ◽  
Secretogranin I ◽  
Backcross Analysis ◽  
Interspecific Backcross Analysis

Mapping Far (First arch) in relation to molecular markers on mouse Chromosome 2

1994 ◽  
Vol 5 (7) ◽  
pp. 450-452 ◽  
Author(s):  
D. M. Juriloff ◽  
M. J. Harris ◽  
D. G. Mah
Keyword(s):  
Molecular Markers ◽  
Mouse Chromosome ◽  
Chromosome 2 ◽  
Mouse Chromosome 2

scholarly journals Quantitative Trait Loci Determining Weight Reduction of Testes and Pituitary by Diethylstilbesterol in LEXF and FXLE Recombinant Inbred Strain Rats

2006 ◽  
Vol 55 (2) ◽  
pp. 91-95 ◽  
Author(s):  
Masayoshi TACHIBANA ◽  
Lingmin LU ◽  
Hiroshi HIAI ◽  
Atsushi TAMURA ◽  
Yoshibumi MATSUSHIMA ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Inbred Strain ◽  
Weight Reduction ◽  
Quantitative Trait ◽  
Recombinant Inbred ◽  
Recombinant Inbred Strain ◽  
Trait Loci

Evidence for two commonly deleted regions on mouse chromosome 2 in γ ray–induced acute myeloid leukemic cells

2002 ◽  
Vol 30 (6) ◽  
pp. 564-570 ◽  
Author(s):  
Kanokporn Rithidech ◽  
John J Dunn ◽  
Bruce A Roe ◽  
Chris R Gordon ◽  
Eugene P Cronkite
Keyword(s):  
Mouse Chromosome ◽  
Leukemic Cells ◽  
Chromosome 2 ◽  
Mouse Chromosome 2 ◽  
Γ Ray ◽  
Acute Myeloid

Mapping of the structural gene for S-adenosyl homocysteine hydrolase to mouse Chromosome 2, and related sequences to Chromosomes 8 and X

1992 ◽  
Vol 3 (11) ◽  
pp. 633-636 ◽  
Author(s):  
Alison Pilz ◽  
Paul Le Tissier ◽  
Heather Moseley ◽  
Jo Peters ◽  
Cathy Abbott
Keyword(s):  
Mouse Chromosome ◽  
Structural Gene ◽  
Chromosome 2 ◽  
Mouse Chromosome 2

Mouse chromosome 2

1998 ◽  
Vol 8 (S1) ◽  
pp. S27-S49 ◽  
Author(s):  
Josephine Peters ◽  
Linda D. Siracusa ◽  
Daniel Pomp ◽  
Aamir R. Zuberi ◽  
Deanna Church ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 2 ◽  
Mouse Chromosome 2
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