A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.

Abstract Interspecific mouse backcross analysis was used to generate a molecular genetic linkage map of mouse chromosome 10. The map locations of the Act-2, Ahi-1, Bcr, Braf, Cdc-2a, Col6a-1, Col6a-2, Cos-1, Esr, Fyn, Gli, Ifg, Igf-1, Myb, Pah, pgcha, Ros-1 and S100b loci were determined. These loci extend over 80% of the genetic length of the chromosome, providing molecular access to many regions of chromosome 10 for the first time. The locations of the genes mapped in this study extend the known regions of synteny between mouse chromosome 10 and human chromosomes 6, 10, 12 and 21, and reveal a novel homology segment between mouse chromosome 10 and human chromosome 22. Several loci may lie close to, or correspond to, known mutations. Preferential transmission of Mus spretus-derived alleles was observed for loci mapping to the central region of mouse chromosome 10.

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A molecular genetic linkage map of mouse chromosome 10, including theMyb, S100b, Pah, Sl, andIfg genes

Biochemical Genetics ◽

10.1007/bf01037591 ◽

1992 ◽

Vol 30 (9-10) ◽

pp. 529-535 ◽

Cited By ~ 1

Author(s):

Atsuko Shimizu ◽

Yuka Sakai ◽

Kyoko Ohno ◽

Shigeo Masaki ◽

Ryozo Kuwano ◽

...

Keyword(s):

Linkage Map ◽

Mouse Chromosome ◽

Genetic Linkage ◽

Genetic Linkage Map ◽

Molecular Genetic ◽

Chromosome 10

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A molecular genetic linkage map of mouse chromosome 2

Genomics ◽

10.1016/0888-7543(90)90479-e ◽

1990 ◽

Vol 6 (3) ◽

pp. 491-504 ◽

Cited By ~ 55

Author(s):

Linda D. Siracusa ◽

Colleen M. Silan ◽

Monica J. Justice ◽

John A. Mercer ◽

Asne R. Bauskin ◽

...

Keyword(s):

Linkage Map ◽

Mouse Chromosome ◽

Genetic Linkage ◽

Genetic Linkage Map ◽

Molecular Genetic ◽

Chromosome 2 ◽

Mouse Chromosome 2

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A molecular genetic linkage map of mouse chromosome 7

Genomics ◽

10.1016/0888-7543(90)90040-2 ◽

1990 ◽

Vol 8 (3) ◽

pp. 525-535 ◽

Cited By ~ 70

Author(s):

Ann M. Saunders ◽

Michael F. Seldin

Keyword(s):

Linkage Map ◽

Mouse Chromosome ◽

Genetic Linkage ◽

Genetic Linkage Map ◽

Molecular Genetic ◽

Chromosome 7

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A molecular genetic linkage map of mouse chromosome 9 with regional localizations for the Gsta, T3g, Ets-1 and Ldlr loci.

Genetics ◽

10.1093/genetics/123.1.165 ◽

1989 ◽

Vol 123 (1) ◽

pp. 165-172

Author(s):

D M Kingsley ◽

N A Jenkins ◽

N G Copeland

Keyword(s):

Linkage Map ◽

Mouse Chromosome ◽

Molecular Genetic ◽

Laboratory Mouse ◽

Density Lipoprotein ◽

Interspecific Backcross ◽

Genetic Maps ◽

Chromosome 9 ◽

Mouse Strains ◽

Mus Spretus

Abstract A 64-centiMorgan linkage map of mouse chromosome 9 was developed using cloned DNA markers and an interspecific backcross between Mus spretus and the C57BL/6J inbred strain. This map was compared to conventional genetic maps using six markers previously localized in laboratory mouse strains. These markers included thymus cell antigen-1, cytochrome P450-3, dilute, transferrin, cholecystokinin, and the G-protein alpha inhibitory subunit. No evidence was seen for segregation distortion, chromosome rearrangements, or altered genetic distances in the results from interspecific backcross mapping. Regional map locations were determined for four genes that were previously assigned to chromosome 9 using somatic cell hybrids. These genes were glutathione S-transferase Ya subunit (Gsta), the T3 gamma subunit, the low density lipoprotein receptor, and the Ets-1 oncogene. The map locations for these genes establish new regions of synteny between mouse chromosome 9 and human chromosomes 6, 11, and 19. In addition, the close linkage detected between the dilute and Gsta loci suggests that the Gsta locus may be part of the dilute/short ear complex, one of the most extensively studied genetic regions of the mouse.

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