Postprandial Hypotension: Simple Treatment But Difficulties With the Diagnosis

As part of our ongoing scaffold hopping work on antimalarial 2-aminothieno[3,2-d]pyrimidin-4-one scaffold, we explored the dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one as a potential new antimalarial series. Using conditions found in the literature, we obtained 2-cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one with 93% yield through a simple treatment. It was then characterized by NMR (1H and 13C) and HRMS. Given the structure of this molecule, its aqueous stability was assessed to determine its suitability for biological tests. To our knowledge, this is the first dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one described.

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Postprandial Hypotension and Spinal Cord Injury

Journal of Clinical Medicine ◽

10.3390/jcm10071417 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1417

Author(s):

Rikke Middelhede Hansen ◽

Klaus Krogh ◽

Joan Sundby ◽

Andrei Krassioukov ◽

Ellen Merete Hagen

Keyword(s):

Blood Pressure ◽

Spinal Cord ◽

Spinal Cord Injury ◽

Cardiovascular Mortality ◽

Blood Pressure Measurement ◽

Ambulatory Blood Pressure Measurement ◽

Postprandial Hypotension ◽

Cord Injury ◽

Time Since Injury ◽

Median Change

Postprandial hypotension (PPH) is defined as a fall of ≥20 mmHg in systolic blood pressure (SBP) or a SBP of <90 mmHg after having been >100 mmHg before the meal within two hours after a meal. The prevalence of PPH among persons with spinal cord injury (SCI) is unknown. Ambulatory blood pressure measurement was performed in 158 persons with SCI, 109 men, median age was 59.1 years (min.:13.2; max.: 86.2). In total, 78 persons (49.4%) had PPH after 114 out of 449 meals (25.4%). The median change in SBP during PPH was −28 mmHg (min.: −87; max.: −15 mmHg) and 96% of the PPH episodes were asymptomatic. The occurrence of PPH was correlated to older age (p = 0.001), level of injury (p = 0.023), and complete SCI (p = 0.000), but not, gender or time since injury. Further studies are needed to elucidate if PPH contributes to the increased cardiovascular mortality in the SCI population.

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Acarbose, the α-glucosidase inhibitor, attenuates the blood pressure and splanchnic blood flow responses to meal in elderly patients with postprandial hypotension concomitant with abnormal glucose metabolism

Blood Pressure Monitoring ◽

10.1097/mbp.0000000000000160 ◽

2016 ◽

Vol 21 (1) ◽

pp. 38-42 ◽

Cited By ~ 5

Author(s):

Wei Qiao ◽

Jing Li ◽

Ying Li ◽

Duan Qian ◽

Lei Chen ◽

...

Keyword(s):

Blood Pressure ◽

Blood Flow ◽

Glucose Metabolism ◽

Elderly Patients ◽

Splanchnic Blood Flow ◽

Postprandial Hypotension ◽

Glucosidase Inhibitor ◽

Abnormal Glucose Metabolism

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A simple treatment for labioversion of the anterior teeth and open bite cases (Clinic)

International Journal of Orthodontia Oral Surgery and Radiography ◽

10.1016/s0099-6963(27)90287-7 ◽

1927 ◽

Vol 13 (12) ◽

pp. 1052-1053

Author(s):

Elizabeth E. Richardson

Keyword(s):

Open Bite ◽

Simple Treatment ◽

Anterior Teeth

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Ferromagnetic nanoparticle-embedded hybrid nanogenerator for harvesting omnidirectional vibration energy

Nanoscale ◽

10.1039/c8nr02039f ◽

2018 ◽

Vol 10 (26) ◽

pp. 12276-12283 ◽

Cited By ~ 7

Author(s):

Daewon Kim ◽

Ik Kyeong Jin ◽

Yang-Kyu Choi

Keyword(s):

Vibration Energy ◽

Triboelectric Nanogenerator ◽

Simple Treatment ◽

Hybrid Nanogenerator ◽

Electromagnetic Generator

A ferromagnetic nanoparticle-embedded hybrid nanogenerator (FHNG) which combines triboelectric nanogenerator (TENG) and electromagnetic generator (EMG) was is proposed. Through a simple treatment, high-triboelectric monolayers of nanoscale thicknesses are formed.

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