scholarly journals Recombinant human follicle stimulating hormone (r-hFSH; Gonal-F) versus highly purified urinary FSH (Metrodin HP): results of a randomized comparative study in women undergoing assisted reproductive techniques

1997 ◽  
Vol 12 (10) ◽  
pp. 2133-2139 ◽  
Author(s):  
C. Bergh ◽  
C. M. Howles ◽  
K. Borg ◽  
L. Hamberger ◽  
B. Josefsson ◽  
...  
Keyword(s):  
Comparative Study ◽  
Follicle Stimulating Hormone ◽  
Assisted Reproductive Techniques ◽  
Reproductive Techniques ◽  
Urinary Fsh ◽  
Stimulating Hormone

THE ACTIVITY OF HUMAN FOLLICLE-STIMULATING HORMONE PREPARATIONS AS MEASURED BY A RESPONSE IN VITRO

1971 ◽  
Vol 51 (1) ◽  
pp. 97-107 ◽  
Author(s):  
MARGARET RYLE
Keyword(s):  
Dose Response ◽  
Mode Of Action ◽  
Follicle Stimulating Hormone ◽  
Culture Conditions ◽  
Thymidine Uptake ◽  
Response Curves ◽  
Standard Culture ◽  
Urinary Fsh ◽  
Stimulating Hormone

SUMMARY Experiments were carried out with two highly purified preparations of human follicle-stimulating hormone (FSH), of pituitary and urinary origin. The uptake of [3H]thymidine was used to measure the response of cultured infantile mouse ovaries. The activity of the pituitary FSH did not decline during 7 days' incubation in the standard culture conditions, nor was it reduced by the culture of infantile mouse ovaries in it. It did not stimulate increased thymidine uptake during the 1st day of culture. Thereafter the rate of thymidine uptake per ovary in response to pituitary FSH remained constant until the end of the 4-day culture period. The urinary FSH became progressively less effective after the 2nd day of incubation. The two preparations gave highly significant linear log dose—response curves in the range 0·01 to 0·64 i.u./ml. The results are discussed in relation to the mode of action of FSH.

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