scholarly journals Corrigendum. IUI for unexplained infertility—a network meta-analysis

2021 ◽  
Vol 27 (2) ◽  
pp. 424-424
Author(s):  
N A Danhof ◽  
R Wang ◽  
M van Wely ◽  
F van der Veen ◽  
B W J Mol ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Unexplained Infertility

scholarly journals Gonadotropins versus oral ovarian stimulation agents for unexplained infertility: a systematic review and meta-analysis

2020 ◽  
Vol 113 (2) ◽  
pp. 417-425.e1 ◽  
Author(s):  
Jessica R. Zolton ◽  
Peter G. Lindner ◽  
Nancy Terry ◽  
Alan H. DeCherney ◽  
Micah J. Hill
Keyword(s):  
Systematic Review ◽  
Ovarian Stimulation ◽  
Meta Analysis ◽  
Unexplained Infertility

scholarly journals Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1950 ◽  
Author(s):  
Mercedes Castaño ◽  
Rubén Gómez-Gordo ◽  
David Cuevas ◽  
Concepción Núñez
Keyword(s):  
Systematic Review ◽  
Coeliac Disease ◽  
Data Extraction ◽  
Meta Analysis ◽  
Numerical Data ◽  
Current Data ◽  
Small Sample ◽  
Unexplained Infertility ◽  
Intestinal Biopsy ◽  
Sample Sizes

We aimed to estimate the seroprevalence and the prevalence of coeliac disease (CD) in women with reproductive problems. A systematic review of English published articles until June 2019 was performed in PubMed and Scopus using the terms: (infertility and (coeliac disease OR gluten) OR (miscarriage and (coeliac disease OR gluten) OR (abortion and (coeliac disease OR gluten). All articles showing numerical data of anti-transglutaminase type 2 or anti-endomisium antibodies, or intestinal biopsy information were included. The study group comprised women with overall infertility, unexplained infertility, or recurrent spontaneous abortions. Two authors independently performed data extraction using a predefined data sheet. The initial search yielded 310 articles, and 23 were selected for data extraction. After meta-analysis, the pooled seroprevalence was very similar for overall and unexplained infertility, with a pooled proportion of around 1.3%–1.6%. This implies three times higher odds of having CD in infertility when compared to controls. The pooled prevalence could not be accurately calculated due to the small sample sizes. Further studies with increased sample sizes are necessary before giving specific recommendations for CD screening in women with reproductive problems, but current data seem to support a higher risk of CD in these women.

Letrozole versus clomiphene citrate for unexplained infertility: A systematic review and meta-analysis

2014 ◽  
Vol 40 (5) ◽  
pp. 1205-1216 ◽  
Author(s):  
Aihai Liu ◽  
Chao Zheng ◽  
Junzhe Lang ◽  
Wenbing Chen
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Clomiphene Citrate ◽  
Unexplained Infertility

Double versus single intrauterine insemination for unexplained infertility: a meta-analysis of randomized trials

2010 ◽  
Vol 94 (4) ◽  
pp. 1261-1266 ◽  
Author(s):  
Nikolaos P. Polyzos ◽  
Spyridon Tzioras ◽  
Davide Mauri ◽  
Athina Tatsioni
Keyword(s):  
Randomized Trials ◽  
Intrauterine Insemination ◽  
Meta Analysis ◽  
Unexplained Infertility

scholarly journals Interventions for unexplained infertility: a systematic review and network meta-analysis

2019 ◽  
Author(s):  
Rui Wang ◽  
Nora A Danhof ◽  
Raissa I Tjon-Kon-Fat ◽  
Marinus JC Eijkemans ◽  
Patrick MM Bossuyt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Unexplained Infertility

scholarly journals Age-related natural fertility outcomes in women over 35 years: a systematic review and individual participant data meta-analysis

2020 ◽  
Vol 35 (8) ◽  
pp. 1808-1820 ◽  
Author(s):  
S J Chua ◽  
N A Danhof ◽  
M H Mochtar ◽  
M van Wely ◽  
D J McLernon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Unexplained Infertility ◽  
Natural Fertility ◽  
Individual Participant Data ◽  
Inclusion Criteria ◽  
Ongoing Pregnancy ◽  
Infertile Women ◽  
Individual Participant ◽  
Natural Conception

Abstract STUDY QUESTION What is the rate of natural conception leading to ongoing pregnancy or livebirth over 6–12 months for infertile women of age ≥35 years? SUMMARY ANSWER Natural conception rates were still clinically relevant in women aged 35 years and above and were significantly higher in women with unexplained infertility compared to those with other diagnoses. WHAT IS KNOWN ALREADY In recent years, increasing numbers of women have attempted to conceive at a later age, resulting in a commensurate increase in the need for ART. However, there is a lack of data on natural fertility outcomes (i.e. no interventions) in women with increasing age. STUDY DESIGN, SIZE, DURATION A systematic review with individual participant data (IPD) meta-analysis was carried out. PubMed, MEDLINE, EMBASE, the Cochrane Library, clinicaltrials.gov were searched until 1 July 2018 including search terms ‘fertility service’, ‘waiting list’, ‘treatment-independent’ and ‘spontaneous conception’. Language restrictions were not imposed. PARTICIPANTS/MATERIALS, SETTING, METHODS Inclusion criteria were studies (at least partly) reporting on infertile couples with female partner of age ≥35 years who attended fertility services, underwent fertility workup (e.g. history, semen analysis, tubal status and ovulation status) and were exposed to natural conception (e.g. independent of treatment such as IVF, ovulation induction and tubal surgery). Studies that exclusively studied only one infertility diagnosis, without including other women presenting to infertility services for other causes of infertility, were excluded. For studies that met the inclusion criteria, study authors were contacted to provide IPD, after which fertility outcomes for women of age ≥35 years were retrieved. Time to pregnancy or livebirth and the effect of increasing age on fertility outcomes after adjustment for other prognostic factors were analysed. Quality of studies was graded with the Newcastle–Ottawa Scale (non-randomised controlled trials (RCTs)) or the Cochrane Risk of Bias tool (for RCTs). MAIN RESULTS AND THE ROLE OF CHANCE We included nine studies (seven cohort studies and two RCTs) (n = 4379 women of at least age 35 years), with the observed composite primary outcome of ongoing pregnancy or livebirth occurring in 429 women (9.8%) over a median follow-up of 5 months (25th to 75th percentile: 2.5–8.5 months). Studies were of moderate to high quality. The probability of natural conception significantly decreased with any diagnosis of infertility, when compared with unexplained infertility. We found non-linear effects of female age and duration of infertility on ongoing pregnancy and tabulated the predicted probabilities for unexplained infertile women aged 35–42 years with either primary or secondary infertility and with a duration of infertility from 1 to 6 years. For a 35-year-old woman with 2 years of primary unexplained infertility, the predicted probability of natural conception leading to ongoing pregnancy or livebirth was 0.15 (95% CI 0.11–0.19) after 6 months and 0.24 (95% CI 0.17–0.30) after 12 months. For a 42-year-old woman, this decreased to 0.08 (95% CI 0.04–0.11) after 6 months and 0.13 (95% CI 0.07–0.18) after 12 months. LIMITATIONS, REASONS FOR CAUTION In the studies selected, there were different study designs, recruitment strategies in different centres, protocols and countries and different methods of assessment of infertility. Data were limited for women above the age of 40 years. WIDER IMPLICATIONS OF THE FINDINGS Women attending fertility services should be encouraged to pursue natural conception while waiting for treatment to commence and after treatment if it is unsuccessful. Our results may aid in counselling women, and, in particular, for those with unexplained infertility. STUDY FUNDING/COMPETING INTEREST(S) S.J.C. received funding from the University of Adelaide Summer Research Scholarship. B.W.M. is supported by a NHMRC Investigator grant (GNT1176437), B.W.M. reports consultancy for ObsEva, Merck, Merck KGaA, iGenomix and Guerbet. B.W.M. reports research support by Merck and Guerbet. PROSPERO REGISTRATION NUMBER CRD42018096552.

Letrozole and Unexplained Infertility: A Contemporary Meta-analysis

2019 ◽  
Vol 41 (6) ◽  
pp. 832-834 ◽  
Author(s):  
Yi-Hong Shao ◽  
Togas Tulandi
Keyword(s):  
Meta Analysis ◽  
Unexplained Infertility
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