Penetration of cefotaxime and desacetylcefotaxime into skin blister fluid

1982 ◽  
Vol 10 (3) ◽  
pp. 193-196 ◽  
Author(s):  
Tom Bergan ◽  
Tore Kalager ◽  
Kjell Block Hellum ◽  
Claus Ola Solberg
Keyword(s):  
Blister Fluid ◽  
Skin Blister

scholarly journals Pharmacokinetic Profile of Meropenem, Administered at 500 Milligrams Every 8 Hours, in Plasma and Cantharidin-Induced Skin Blister Fluid

2003 ◽  
Vol 47 (5) ◽  
pp. 1771-1773 ◽  
Author(s):  
Dana Maglio ◽  
Renli Teng ◽  
Per T. Thyrum ◽  
Charles H. Nightingale ◽  
David P. Nicolau
Keyword(s):  
Soft Tissue ◽  
Elimination Rate ◽  
Pharmacokinetic Profile ◽  
Soft Tissue Infections ◽  
Blister Fluid ◽  
Skin Blister ◽  
The Mean

ABSTRACT The pharmacokinetic disposition of meropenem, administered at 500 mg every 8 h, in plasma and cantharidin-induced blister fluid is described. Peak meropenem concentrations in blister fluid lagged behind peak meropenem concentrations in plasma, while a lower elimination rate from blister fluid was also noted. The mean penetration of meropenem into blister fluid was 67%. The pharmacokinetic profile of meropenem in blister fluid supports the utility of this dose in the management of skin and soft tissue infections.

scholarly journals Pharmacokinetics and Pharmacodynamics of Levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in Human Skin Blister Fluid

2000 ◽  
Vol 44 (5) ◽  
pp. 1352-1355 ◽  
Author(s):  
Andrej Trampuz ◽  
Markus Wenk ◽  
Zarko Rajacic ◽  
Werner Zimmerli
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Oral Dose ◽  
Human Skin ◽  
Bactericidal Activity ◽  
Ex Vivo ◽  
Blister Fluid ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Skin Blister ◽  
And Staphylococcus Aureus

ABSTRACT The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6-h incubation.

Ofloxacin: serum and skin blister fluid pharmacokinetics in the fasting and non-fasting state

1986 ◽  
Vol 17 (6) ◽  
pp. 795-800 ◽  
Author(s):  
T. Kalager ◽  
A. Digranes ◽  
T. Bergan ◽  
T. Rolstad
Keyword(s):  
Fasting State ◽  
Blister Fluid ◽  
Skin Blister

Levels of itraconazole in skin blister fluid after a single oral dose and during repetitive administration

1990 ◽  
Vol 22 (2) ◽  
pp. 211-215 ◽  
Author(s):  
Monika Schäfer-Korting ◽  
Hans Christian Korting ◽  
Andreas Lukacs ◽  
Jos Heykants ◽  
Hans Behrendt
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Blister Fluid ◽  
Skin Blister

Tryptase concentration in skin blister fluid from patients with bullous skin conditions

1996 ◽  
Vol 288 (12) ◽  
pp. 771-773 ◽  
Author(s):  
Knut Brockow ◽  
Dietrich Abeck ◽  
Klaus Hermann ◽  
Jahannes Ring
Keyword(s):  
Blister Fluid ◽  
Skin Blister ◽  
Skin Conditions

Penetration of trimethoprim and sulfamethoxazole into skin blister fluid

1983 ◽  
Vol 25 (6) ◽  
pp. 825-827 ◽  
Author(s):  
A. Nowak ◽  
M. Kadyk�w ◽  
A. Klimowicz
Keyword(s):  
Blister Fluid ◽  
Skin Blister
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