The in-vitro activity of CP-62,993 against Haemophilus influenzae, Branhamella catarrhalis, staphylococci and streptococci

1988 ◽  
Vol 21 (4) ◽  
pp. 405-411 ◽  
Author(s):  
K. T. Dunkin ◽  
S. Jones ◽  
A. J. Howard
Keyword(s):  
Haemophilus Influenzae ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Branhamella Catarrhalis

scholarly journals In Vitro Activity of Tebipenem, a New Oral Carbapenem Antibiotic, against β-Lactamase-Nonproducing, Ampicillin-Resistant Haemophilus influenzae

2010 ◽  
Vol 54 (9) ◽  
pp. 3970-3973 ◽  
Author(s):  
Kozue Kishii ◽  
Naoko Chiba ◽  
Miyuki Morozumi ◽  
Akiko Ono ◽  
Takashi Ida ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Bactericidal Activity ◽  
Gene Mutations ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Oral Antibiotics ◽  
Pcr Identification ◽  
Minimal Concentration ◽  
Carbapenem Antibiotic

ABSTRACT In vitro activity of tebipenem, a new oral carbapenem antibiotic, against clinical Haemophilus influenzae isolates was compared with those of 8 reference agents. Isolates were classified into 6 resistance classes after PCR identification of β-lactamase genes and ftsI gene mutations. For all isolates, the minimal concentration at which 90% of isolates were inhibited was lower for tebipenem than for the reference oral antibiotics, except for cefditoren. Tebipenem also showed excellent bactericidal activity against β-lactamase-nonproducing, ampicillin-resistant isolates.

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