Reverse Phase High Performance Liquid Chromatographic Determination of Phenprocoumon in Tablets
Keyword(s):
Abstract A high performance liquid chromatographic procedure has been developed for the assay of phenprocoumon in tablets. In comparison to the present official USP assay procedure, it is equivalent in precision and accuracy and is faster and more specific. A mobile phase consisting of a 1% solution of acetic acid in acetonitrile-water (4 + 3) separates phenprocoumon from warfarin internal standard on a 6 μm octadecylsilane (ODS) column with UV detection at 311 nm. The method enables the concurrent determination of phenprocoumon and possible contaminants such as salicylic acid.
1991 ◽
Vol 558
(1)
◽
pp. 115-124
◽
2003 ◽
Vol 68
(11)
◽
pp. 883-892
◽
2011 ◽
Vol 2
(3)
◽
1982 ◽
Vol 28
(10)
◽
pp. 2143-2148
◽
2006 ◽
Vol 68
(4)
◽
pp. 514
◽