Extracellular Cleavage of Bullous Pemphigoid Antigen 180/Type XVII Collagen and Its Involvement in Hemidesmosomal Disassembly

2003 ◽  
Vol 133 (2) ◽  
pp. 197-206 ◽  
Author(s):  
Y. Hirako
Keyword(s):  
Bullous Pemphigoid ◽  
Bullous Pemphigoid Antigen ◽  
Xvii Collagen

scholarly journals Type XVII Collagen Regulates Lamellipod Stability, Cell Motility, and Signaling to Rac1 by Targeting Bullous Pemphigoid Antigen 1e to α6β4 Integrin

2011 ◽  
Vol 286 (30) ◽  
pp. 26768-26780 ◽  
Author(s):  
Kevin J. Hamill ◽  
Susan B. Hopkinson ◽  
Marcel F. Jonkman ◽  
Jonathan C. R. Jones
Keyword(s):  
Cell Motility ◽  
Bullous Pemphigoid ◽  
Bullous Pemphigoid Antigen ◽  
Α6β4 Integrin ◽  
Xvii Collagen

scholarly journals The 97-kDa (LABD97) and 120-kDa (LAD-1) Fragments of Bullous Pemphigoid Antigen 180/Type XVII Collagen Have Different N-Termini

2003 ◽  
Vol 121 (6) ◽  
pp. 1554-1556 ◽  
Author(s):  
Yuji Nishizawa ◽  
Katrin Marcus ◽  
Helmut E. Meyer ◽  
Elke Butt ◽  
Katsushi Owaribe ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Bullous Pemphigoid Antigen ◽  
Xvii Collagen

scholarly journals IgG from Patients with Bullous Pemphigoid Depletes Cultured Keratinocytes of the 180-kDa Bullous Pemphigoid Antigen (Type XVII Collagen) and Weakens Cell Attachment

2009 ◽  
Vol 129 (4) ◽  
pp. 919-926 ◽  
Author(s):  
Hiroaki Iwata ◽  
Naoko Kamio ◽  
Yumi Aoyama ◽  
Yukari Yamamoto ◽  
Yoshiaki Hirako ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Cell Attachment ◽  
Cultured Keratinocytes ◽  
Bullous Pemphigoid Antigen ◽  
Xvii Collagen

scholarly journals Gambaran Dermal-Epidermal Junction Pada Bullous Pemphigoid Dan Epidermolysis Bullosa Acquisita

Medicinus ◽  
2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Caroline Budiman ◽  
Mutia Devi ◽  
HM Athuf Thaha
Keyword(s):  
Autoimmune Disease ◽  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Epidermolysis Bullosa ◽  
Intermediate Filament ◽  
Autoimmune Disorder ◽  
Epidermolysis Bullosa Acquisita ◽  
Bullous Pemphigoid Antigen ◽  
Xvii Collagen

Epidermis and dermis of the skin attach each other because of the role of a structure which is called dermal-epidermal junction. The dermal-epidermal junction can be divided into three distinct zones named hemidesmosome-keratin intermediate filament complex, basement membrane, and anchoring fibril. Each part of the distinct zone has significant components for the integrity of the skin. Bullous pemphigoid is an autoimmune disorder caused by autoantibody against a 180-kDa molecule now called Bullous Pemphigoid Antigen 2 (BPAG2) or type XVII collagen within basement membrane. To date, the patophysiology and the components of dermal-epidermal junction that induce the blister formation remain unclear. Epidermolysis bullosa acquisita is an autoimmune disease with sub-epidermal blistering associated with autoimmunity to the collagen within anchoring fibrils. The pathophysiology and etiology—again—remain unknown.

Sign in / Sign up

Export Citation Format

Share Document