scholarly journals Large mediastinal germ cell tumor with disease progression during systemic therapy

2021 ◽  
Vol 2021 (9) ◽  
Author(s):  
Diana S Hsu ◽  
Sawley A Wilde ◽  
Kian C Banks ◽  
Jeffrey B Velotta
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Acute Onset ◽  
Cell Tumor ◽  
Anterior Mediastinal Mass ◽  
En Bloc ◽  
Mixed Germ Cell Tumor ◽  
Clamshell Incision

Abstract A 29-year-old male developed acute onset severe shortness of breath and fevers and was found to have a 17 cm anterior mediastinal mass with immature teratoma and possible mixed germ cell tumor on biopsy. He remained hospitalized during neoadjuvant cisplatin-based chemotherapy due to compressive symptoms from his mass and neutropenic fevers. Despite 3 cycles of therapy, his tumor mildly increased in size. After multidisciplinary discussion, he underwent urgent en bloc resection with a right hemi-clamshell incision. His postoperative course was uncomplicated and he was discharged to home within a week. His final pathology demonstrated mixed germ cell tumor.

scholarly journals Mediastinal mixed germ cell tumor: A case report and literature review

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 892-898
Author(s):  
Xianwen Hu ◽  
Dandan Li ◽  
Jinhua Xia ◽  
Pan Wang ◽  
Jiong Cai
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Embryonal Carcinoma ◽  
Yolk Sac ◽  
Immature Teratoma ◽  
Cell Tumor ◽  
Yolk Sac Tumor ◽  
Medical Attention ◽  
Ct Guided ◽  
Mixed Germ Cell Tumor

Abstract Mixed germ cell tumor (MGCT) mainly occurs in young women’s ovaries and men’s testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yolk sac tumor, immature teratoma, and embryonal carcinoma, has not been reported previously. A 12-year-old male sought medical attention for chest discomfort and underwent a computed tomography (CT) scan. A large soft tissue mass occupying most of the left thoracic cavity and mediastinum was detected. A CT-guided biopsy was performed, and an MGCT was diagnosed with pathological components, including yolk sac tumor, immature teratoma, and a small amount of embryonal carcinoma. Due to the large size of the tumor, the patient was treated with an EP regimen (etoposide + cisplatin) and paclitaxel + ifosfamide + cisplatin interstitial chemotherapy. The patient was followed up for 6 months and was alive with the disease. To the best of our knowledge, this is the 10th patient with MGCT in the mediastinum. The incidence of mediastinal MGCT is low, but it should still be considered one of the differential diagnoses of isolated pleural fibroma and neurogenic tumors.

Malignant Transformation and Treatment of Cystic Mixed Germ Cell Tumor

2016 ◽  
Vol 2 (1) ◽  
pp. 25-30
Author(s):  
Yapeng Zhao ◽  
Hongyu Duan ◽  
Qinghui Zhang ◽  
Bingxin Shi ◽  
Hui Liang ◽  
...  
Keyword(s):  
Germ Cell ◽  
Malignant Transformation ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Mixed Germ Cell Tumor

scholarly journals Surgical treatment outcome of giant cell tumor of distal ulna: En bloc resection vs. curettage and bone graft

2018 ◽  
Vol 32 (1) ◽  
pp. 249-253
Author(s):  
Khodamorad Jamshidi ◽  
Mehrdad Bahrabadi ◽  
Abolfazl Bagherifard ◽  
Mehdi Mohamadpour
Keyword(s):  
Treatment Outcome ◽  
Surgical Treatment ◽  
Bone Graft ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Cell Tumor ◽  
Distal Ulna ◽  
En Bloc

scholarly journals Mixed germ cell tumor complicating an intra-abdominal cryptorchidism

2013 ◽  
Vol 6 (3-4) ◽  
pp. 122-123 ◽  
Author(s):  
Ahmed Abu-Zaid ◽  
Ayman Azzam ◽  
Tarek Amin
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Mixed Germ Cell Tumor

Suprasellar Mixed Germ Cell Tumor: Case Report

2003 ◽  
Vol 48 (1) ◽  
pp. 95
Author(s):  
Eun Ja Lee ◽  
Hye Kyung Lee ◽  
Mi Sung Kim
Keyword(s):  
Case Report ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
Mixed Germ Cell Tumor

scholarly journals A rare case of mixed germ cell tumor in a teenage girl: a case report

2017 ◽  
Vol 6 (6) ◽  
pp. 2663
Author(s):  
Faraz S. Vali ◽  
Amit Kyal ◽  
Parul I. Chaudhary ◽  
Sujatha Das ◽  
Aprateem Mukherjee ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Embryonal Carcinoma ◽  
Germ Cell Tumors ◽  
Cell Tumor ◽  
Ca 125 ◽  
Gestational Choriocarcinoma ◽  
Mixed Germ Cell Tumor ◽  
Initial Surgery ◽  
Alpha Feto Protein

Germ cell tumors represent only 20% to 25% of all benign and malignant ovarian neoplasms. Mixed germ cell tumors are a rare variety of non–dysgerminomatous germ cell tumors. They contain two or more elements; the most frequent combination being a dysgerminoma and an EST (Endodermal Sinus Tumor). We present a case of malignant mixed germ cell tumor comprising of yolk sac tumor, embryonal carcinoma and choriocarcinoma. A 13-year-old girl presented with a huge 25 x 18 cm mass in abdomen with raised values of CA-125, hCG, AFP (alpha-feto protein) and LDH (lactate dehydrogenase). She underwent laparotomy followed by unilateral salpingoopherectomy and infracolic omentectomy. Histopathology report revealed malignant mixed germ cell tumor comprising predominantly of EST with elements of embryonal carcinoma and non-gestational choriocarcinoma. Following surgery, she was started on adjuvant chemotherapy (Bleomycin, Etoposide and Cisplatin regimen). Mixed germ cell tumor (YST/EST, non-gestational choriocarcinoma and embryonal carcinoma) is a very rare tumor. Careful initial surgery with adequate staging biopsies followed by combination chemotherapy can greatly improve the prognosis of these patients

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