Cardiac Transplants

Author(s):  
Patrizio Lancellotti ◽  
Bernard Cosyns

Transthoracic echocardiography is a primary non-invasive modality for investigation of heart transplant recipients. It provides comprehensive information about cardiac structure and function and may be of interest during cardiac biopsy. Precluded by a brief summary of orthotopic and heterotopic cardiac transplantation, this chapter highlights the usefulness of Doppler echocardiography in the assessment of left ventricular and right ventricular systolic and diastolic function, of left ventricular mass, valvular heart disease, pulmonary arterial hypertension and pericardial effusion in heart transplant recipients. Normal echocardiographic findings in a transplanted heart are summarized alongside echocardiographic indicators of rejection.

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2338
Author(s):  
Daniele Masarone ◽  
Michelle Kittleson ◽  
Rita Gravino ◽  
Fabio Valente ◽  
Andrea Petraio ◽  
...  

Transthoracic echocardiography is the primary non-invasive modality for the investigation of heart transplant recipients. It is a versatile tool that provides comprehensive information on cardiac structure and function. Echocardiography is also helpful in diagnosing primary graft dysfunction and evaluating the effectiveness of therapeutic approaches for this condition. In acute rejection, echocardiography is useful with suspected cellular or antibody-mediated rejection, with findings confirmed and quantified by endomyocardial biopsy. For identifying chronic rejection, ultrasound has a more significant role and, in some specific patients (e.g., patients with renal failure), it may offer a role comparable to coronary angiography to identify cardiac allograft vasculopathy. This review highlights the usefulness of echocardiography in evaluating normal graft function and its role in the management of heart transplant recipients.


2008 ◽  
Vol 29 (22) ◽  
pp. 2742-2750 ◽  
Author(s):  
S. S. Kushwaha ◽  
E. Raichlin ◽  
Y. Sheinin ◽  
W. K. Kremers ◽  
K. Chandrasekaran ◽  
...  

1993 ◽  
Vol 422 (6) ◽  
pp. 453-458 ◽  
Author(s):  
Pietro Gallo ◽  
Giorgio Baroldi ◽  
Gaetano Thiene ◽  
Lucio Agozzino ◽  
Eloisa Arbustini ◽  
...  

1998 ◽  
Vol 85 (6) ◽  
pp. 2270-2276 ◽  
Author(s):  
Bernard Geny ◽  
Anne Charloux ◽  
Eliane Lampert ◽  
Jean Lonsdorfer ◽  
Pascal Haberey ◽  
...  

We investigated the atrial (ANP) and brain natriuretic peptides (BNP), catecholamines, heart rate, and blood pressure responses to graded upright maximal cycling exercise of eight matched healthy subjects and cardiac-denervated heart transplant recipients (HTR). Baseline heart rate and diastolic blood pressure, together with ANP (15.2 ± 3.7 vs. 4.4 ± 0.8 pmol/l; P < 0.01) and BNP (14.3 ± 2.6 vs. 7.4 ± 0.6 pmol/l; P< 0.01), were elevated in HTR, but catecholamine levels were similar in both groups. Peak exercise O2uptake and heart rate were lower in HTR. Exercise-induced maximal ANP increase was similar in both groups (167 ± 34 vs. 216 ± 47%). Enhanced BNP increase was significant only in HTR (37 ± 8 vs. 16 ± 8%; P < 0.05). Similar norepinephrine but lower peak epinephrine levels were observed in HTR. ANP and heart rate changes from rest to 75% peak exercise were negatively correlated ( r = −0.76, P < 0.05), and BNP increase was correlated with left ventricular mass index ( r = 0.83, P < 0.01) after heart transplantation. Although ANP increase was not exaggerated, these data support the idea that the chronotropic limitation secondary to sinus node denervation might stimulate ANP release during early exercise in HTR. Furthermore, the BNP response to maximal exercise, which is related to the left ventricular mass index of HTR, is enhanced after heart transplantation.


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