scholarly journals Mutagenesis and DNA adduct formation in the mouse mammary gland exposed to 2-hydroxyamino-1-methyl-6-phenylimidazo-[4,5-b]pyridine in whole organ culture

Mutagenesis ◽  
2003 ◽  
Vol 18 (1) ◽  
pp. 7-12 ◽  
Author(s):  
E. G. Snyderwine
Keyword(s):  
Mammary Gland ◽  
Organ Culture ◽  
Mouse Mammary Gland ◽  
Adduct Formation ◽  
Dna Adduct

scholarly journals Circadian Regulation of Benzo[a]Pyrene Metabolism and DNA Adduct Formation in Breast Cells and the Mouse Mammary Gland

2016 ◽  
Vol 91 (3) ◽  
pp. 178-188 ◽  
Author(s):  
Emily E. Schmitt ◽  
Rola Barhoumi ◽  
Richard P. Metz ◽  
Weston W. Porter
Keyword(s):  
Mammary Gland ◽  
Mouse Mammary Gland ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Circadian Regulation ◽  
Breast Cells

scholarly journals Naturally occurring coumarins inhibit 7,12-dimethylbenz[ a ]anthracene DNA adduct formation in mouse mammary gland

2005 ◽  
Vol 27 (6) ◽  
pp. 1204-1213 ◽  
Author(s):  
Misty Prince ◽  
Cheryl T. Campbell ◽  
Taylor A. Robertson ◽  
Amy J. Wells ◽  
Heather E. Kleiner
Keyword(s):  
Mammary Gland ◽  
Mouse Mammary Gland ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Naturally Occurring

Nitroreduction of 4-Nitropyrene Is Primarily Responsible for DNA Adduct Formation in the Mammary Gland of Female CD Rats

1999 ◽  
Vol 12 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Young-Heum Chae ◽  
Ben-Yi Ji ◽  
Jyh-Ming Lin ◽  
Peter P. Fu ◽  
Bongsup P. Cho ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Adduct Formation ◽  
Dna Adduct

Possible mechanisms for PhIP-DNA adduct formation in the mammary gland of female Sprague-Dawley rats

1995 ◽  
Vol 16 (11) ◽  
pp. 2725-2731 ◽  
Author(s):  
Amit Ghoshal ◽  
Cindy D. Davis ◽  
Herman A.J. Schut ◽  
Elizabeth G. Snyderwine
Keyword(s):  
Mammary Gland ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

A STUDY ON THE EFFECT OF INSULIN ON DNA, RNA AND PROTEIN SYNTHESIS IN MOUSE MAMMARY GLAND TISSUE IN ORGAN CULTURE

1971 ◽  
Vol 50 (2) ◽  
pp. 241-249 ◽  
Author(s):  
D. Y. WANG ◽  
VICKY AMOR
Keyword(s):  
Protein Synthesis ◽  
Mammary Gland ◽  
Organ Culture ◽  
Mouse Mammary Gland ◽  
Metabolic Inhibitors ◽  
Synthetic Activity ◽  
Insulin Stimulation ◽  
Mammary Gland Tissue ◽  
Gland Tissue ◽  
Rna And Protein Synthesis

SUMMARY The rates of synthesis of DNA, RNA and protein of mouse mammary gland explants in organ culture have been determined. Stimulation with insulin resulted in maximal rates of synthesis of these components, all occurring between 18 and 22 h of culture. The use of metabolic inhibitors of DNA, RNA or protein synthesis showed that after insulin stimulation, inhibition of any one of these processes was associated with a reduction in the synthesis of the other two components. Also the maximal rate of protein synthesis is governed by the net amount of RNA formed throughout the period of culture. Evidence is presented that the stimulation of DNA, RNA or protein synthesis by insulin is not due to increased transport of amino acids and that insulin appears to act rapidly on processes which subsequently lead to enhanced synthetic activity.

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