scholarly journals Acute angulation of the left renal artery imitating renal artery stenosis in a patient with neurofibromatosis type 1

1999 ◽  
Vol 14 (7) ◽  
pp. 1767-1770 ◽  
Author(s):  
G Vrentzos
Keyword(s):  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Artery Stenosis ◽  
Left Renal Artery

scholarly journals Revascularization in a 17-Year-Old Girl with Neurofibromatosis and Severe Hypertension Caused by Renal Artery Stenosis

2017 ◽  
Vol 44 (1) ◽  
pp. 50-54
Author(s):  
Carmen C. Beladan ◽  
Oliviana D. Geavlete ◽  
Simona Botezatu ◽  
Marin Postu ◽  
Bogdan A. Popescu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Neurofibromatosis Type 1 ◽  
Severe Hypertension ◽  
Neurofibromatosis Type ◽  
Artery Stenosis ◽  
Left Renal Artery ◽  
Renal Angioplasty

Renal artery stenosis caused by neurofibromatosis is a rare cause of renovascular hypertension. This hypertension can develop during childhood and is one of the leading causes of poor outcome. We report the case of a 17-year-old girl who was incidentally diagnosed with severe hypertension. During her examination for secondary hypertension, we reached a diagnosis of neurofibromatosis type 1 on the basis of a cluster of typical findings: optic nerve glioma, café au lait spots, nodular neurofibromas, and axillary freckling. Renal angiograms revealed a hemodynamically significant left renal artery stenosis (70%). Renal angioplasty with a self-expanding stent was performed one month later for rapidly progressive renal artery stenosis (90%) and uncontrolled blood pressure. Excellent blood pressure control resulted immediately and was maintained as of the 2-year follow-up evaluation. We think that percutaneous transluminal renal angioplasty can be effective in select patients who have neurofibromatosis type 1 and refractory hypertension caused by renal artery stenosis.

A case of coarctation of the abdominal aorta and renal artery stenosis due to neurofibromatosis type 1

2016 ◽  
Vol 93 (1098) ◽  
pp. 235-236 ◽  
Author(s):  
Satyam Veean ◽  
Nancy Thakkar ◽  
Supriya Gupta ◽  
Jayanth Keshavamurthy
Keyword(s):  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Abdominal Aorta ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Artery Stenosis

scholarly journals Neurofibromatosis type 1 with adrenal pheochromocytoma and renal artery stenosis: an uncommon entity of arterial hypertension

Research ◽  
2014 ◽  
Vol 1 ◽  
Author(s):  
L Petramala ◽  
L Zinnamosca ◽  
A Settevendemmie ◽  
A Concistré ◽  
C Marinelli ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Artery Stenosis ◽  
Adrenal Pheochromocytoma

Molecular genetic evaluation of pediatric renovascular hypertension due to renal artery stenosis and abdominal aortic coarctation in neurofibromatosis type 1

2021 ◽  
Author(s):  
Dawn M Coleman ◽  
Yu Wang ◽  
Min-Lee Yang ◽  
Kristina L Hunker ◽  
Isabelle Birt ◽  
...  
Keyword(s):  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Renovascular Hypertension ◽  
Neurofibromatosis Type 1 ◽  
Aortic Coarctation ◽  
Mapk Pathway ◽  
Neurofibromatosis Type ◽  
Artery Stenosis ◽  
Abdominal Aortic

Abstract The etiology of renal artery stenosis (RAS) and abdominal aortic coarctation (AAC) causing the midaortic syndrome (MAS), often resulting in renovascular hypertension (RVH), remains ill-defined. Neurofibromatosis type 1 (NF-1) is frequently observed in children with RVH. Consecutive pediatric patients (N = 102) presenting with RVH secondary to RAS with and without concurrent AAC were prospectively enrolled in a clinical data base, and blood, saliva and operative tissue, when available, were collected. Among the 102 children, 13 were having a concurrent clinical diagnosis of NF-1 (12.5%). Whole exome sequencing was performed for germline variant detection, and RNA-Seq analysis of NF1, MAPK pathway genes and MCP1 levels were undertaken in five NF-1 stenotic renal arteries, as well as control renal and mesenteric arteries from children with no known vasculopathy or NF-1. In 11 unrelated children with sequencing data, 11 NF1 genetic variants were identified, of which 10 had not been reported in gnomAD. Histologic analysis of NF-1 RAS specimens consistently revealed intimal thickening, disruption of the internal elastic lamina and medial thinning. Analysis of transcript expression in arterial lesions documented an approximately 5-fold reduction in NF1 expression, confirming heterozygosity, MAPK pathway activation and increased MCP1 expression. In summary, NF-1-related RVH in children is rare but often severe and progressive and, as such, important to recognize. It is associated with histologic and molecular features consistent with an aggressive adverse vascular remodeling process. Further research is necessary to define the mechanisms underlying these findings.

Endovascular Management of Neurofibromatosis Type I-Associated Vasculopathy: A Case Series and Brief Review of the Literature

2019 ◽  
Vol 54 (2) ◽  
pp. 182-190 ◽  
Author(s):  
Joel Raborn ◽  
Benjamin J. McCafferty ◽  
Andrew J. Gunn ◽  
Sherif Moawad ◽  
Khalid Mahmoud ◽  
...  
Keyword(s):  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Neurofibromatosis Type 1 ◽  
Case Series ◽  
Neurofibromatosis Type ◽  
Artery Stenosis ◽  
Type I ◽  
Endovascular Management ◽  
Review Of The Literature

Purpose: Neurofibromatosis type 1 (NF1) is an autosomal-dominant disorder found in approximately 1 of every 3000 individuals. Neurofibromatosis type 1 can have vascular manifestations including aneurysms, stenoses, and arteriovenous malformations. The purpose of this article is to describe the clinical manifestations of NF1 vasculopathy, discuss therapeutic options, and highlight endovascular therapies from our institutional experience. Materials and Methods: The radiology information system was searched for cases of NF1. Cases with vasculopathy managed with endovascular therapies were included. Demographics, clinical histories, procedural details, and outcomes were recorded. A review of the literature for the management strategies of NF1 vasculopathy was performed. Results: Two pediatric patients with NF1 were identified, both of whom presented with hypertension found to be secondary to renal artery stenosis. One of the patients also had infrarenal aortic narrowing. Both patients were successfully treated with balloon angioplasty, resulting in improved blood pressures. The review of the literature identified case series of pharmacologic, surgical, and endovascular therapies, although, endovascular therapies appear to be preferred due to lower morbidity and mortality. Conclusions: NF1 vasculopathy is a rare condition that most often presents with hypertension due to renal artery stenosis. In these situations, endovascular management is the preferred approach.

Traumatic Left Renal Artery Stenosis Managed with Splenorenal Bypass

1990 ◽  
Vol 30 (12) ◽  
pp. 1594-1596 ◽  
Author(s):  
GARY W. BARONE ◽  
MARK B. KAHN ◽  
JAMES M. COOK ◽  
BERNARD W. THOMPSON ◽  
ROBERT W. BARNES ◽  
...  
Keyword(s):  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Artery Stenosis ◽  
Left Renal Artery

scholarly journals Renal artery stenosis of atherosclerotic etiology – the single kidney surgical recurrence 12 years after nephrectomy

2016 ◽  
Vol 63 (3) ◽  
pp. 251-254
Author(s):  
Maria Daniela Tănăsescu ◽  
◽  
Marcel Pălămar ◽  
Mihai Ovidiu Comşa ◽  
Alexandru Mincă ◽  
...  
Keyword(s):  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Left Kidney ◽  
Secondary Hypertension ◽  
Artery Stenosis ◽  
The Other ◽  
Left Renal Artery ◽  
Arterial Blood ◽  
The Moment ◽  
The Right

Objectives. Renal artery stenosis, as main cause of renovascular secondary hypertension, is mainly caused by atherosclerosis of large vessels and is clinically characterized by resistant or malignant hypertension, impacting the kidney function to various degrees. The present article brings into attention the case of a patient which developed renal artery stenosis on the left kidney, the same condition occurring 12 years later on the right kidney. Material and method. Our patient was initially diagnosed at the age of 48 with complete occlusion of the left renal artery, for which left nephrectomy was performed, while the right artery was normal. Twelve years later she presents with renal artery stenosis on the right kidney, which is treat by stent-angioplasty. Results. After surgery, the patient’s evolution was positive, with amelioration of the laboratory values, in parallel to the arterial blood pressure. Discussions. The probability that, in the moment of diagnosis of renal artery stenosis with progressive evolution to occlusion caused by atherosclerosis, the other artery would be normal, both seen by ultrasonography and angiography, while years later to develop stenosis, is minimal. Up to present, the literature holds little evidence of such similar cases. Conclusions. In the particular case of patients that were diagnosed with severe renal artery stenosis of atherosclerotic origin and had only one of the arteries affected, it is necessary to keep a permanent monitoring, justified by the risk of development of the same pathology to the other artery

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