Duodenal Carcinoid Tumours, Phaeochromocytoma and Neurofibromatosis: Islet Cell Tumour, Phaeochromocytoma and the Von Hippel-Lindau Complex: Two Distinctive Neuroendocrine Syndromes

QJM ◽  
1987 ◽  
2014 ◽  
Author(s):  
Dhanya Kalathil ◽  
Simon Roughneen ◽  
Momin Shah ◽  
Ali Akram ◽  
Reza Zaidi ◽  
...  

BMJ ◽  
1970 ◽  
Vol 3 (5722) ◽  
pp. 562-563 ◽  
Author(s):  
N N Stanley ◽  
V Marks ◽  
L Kreel ◽  
N McIntyre

2019 ◽  
Vol 5 (1) ◽  
pp. 205511691985612
Author(s):  
Alexandra Guillen ◽  
Lorenzo Ressel ◽  
Riccardo Finotello ◽  
Alexander J German ◽  
Alistair Freeman ◽  
...  

Case summary An 11-year-old male neutered domestic shorthair cat presented with behavioural changes. Physical examination revealed bradycardia and a cranial abdominal mass. The cat was persistently hypoglycaemic (1.2 mmol/l; reference interval [RI] 3.5–5.5 mmol/l) with decreased fructosamine concentration suggesting chronic hypoglycaemia, and decreased insulin concentration excluding insulinoma. Alanine aminotransferase activity was markedly increased (1219.31 U/l; RI 15–60 U/l). On staging CT a large, multilobulated hepatic mass was identified, with no evidence of metastatic disease. After surgical removal serum glucose concentration and heart rate quickly returned to within the RIs. Histopathology was consistent with a solid-to-trabecular, well-differentiated, hepatocellular carcinoma. There was no recurrence of signs or mass during 8 months of follow-up, and the cat was still alive 20 months after surgery. Relevance and novel information Non-islet-cell tumour hypoglycaemia (NICTH) is a rare but life-threatening paraneoplastic syndrome. In humans, hepatocellular carcinoma is the most common epithelial tumour causing NICTH, but these are uncommon in cats, and associated paraneoplastic hypoglycaemia has not been reported. Possible mechanisms include aberrant secretion of big insulin growth factor 2; however, this could not be confirmed. NICTH should be considered in the differential diagnosis of cats with persistent hypoglycaemia.


1999 ◽  
Vol 51 (2) ◽  
pp. 147-147 ◽  
Author(s):  
J. D. Teale

The Lancet ◽  
1952 ◽  
Vol 259 (6702) ◽  
pp. 289-293 ◽  
Author(s):  
A.N. Smith ◽  
J.B. Cochran

2000 ◽  
Vol 73 (865) ◽  
pp. 83-86 ◽  
Author(s):  
S Y Baek ◽  
B C Kang ◽  
H Y Choi ◽  
S W Lee

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