scholarly journals Toxicity and Carcinogenicity of Δ9-Tetrahydrocannabinol in Fischer Rats and B6C3F1 Mice

1996 ◽  
Vol 30 (1) ◽  
pp. 109-117 ◽  
Author(s):  
P. C. CHAN ◽  
R. C. SILLS ◽  
A. G. BRAUN ◽  
J. K. HASEMAN ◽  
J. R. BUCHER
Keyword(s):  
B6c3f1 Mice ◽  
Fischer Rats

Collaborative Studies on the Salmonella/Microsome Mutagenicity Assay

1979 ◽  
Vol 62 (4) ◽  
pp. 874-882
Author(s):  
Virginia C Dunkel
Keyword(s):  
Collaborative Study ◽  
Metabolic Activation ◽  
Plate Test ◽  
The Third ◽  
Collaborative Studies ◽  
Mutagenicity Assay ◽  
B6c3f1 Mice ◽  
Fischer Rats ◽  
Interlaboratory Reproducibility ◽  
Positive Results

Abstract Although the Salmonella/plate test has been used extensively, a collaborative study was undertaken to determine the interlaboratory reproducibility of this microbial mutagenicity assay. Four laboratories participating in the study have completed testing, under code, of 61 carcinogens and noncarcinogens. All chemicals were tested both with and without metabolic activation in Salmonella typhimurium strains TA1535, 1537, 1538, 98, and 100. The metabolic activation systems used were derived from the livers of both uninduced and Aroclor 1254-induced Fischer rats, B6C3F1 mice, and Syrian hamsters. Analysis of the results on 23 of the chemicals tested in 3 of the participating laboratories showed that 8 were negative when tested in all laboratories and 13 were positive. Two chemicals gave positive results in 2 laboratories; the same 2 chemicals were negative when tested in the third laboratory.

scholarly journals Carcinogenesis Studies of Dichlorvos in Fischer Rats and B6C3F1 Mice

1991 ◽  
Vol 82 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Po C. Chan ◽  
James Huff ◽  
Joseph K. Haseman ◽  
Roger Alison ◽  
J. D. Prejean
Keyword(s):  
B6c3f1 Mice ◽  
Fischer Rats

Dermal Toxicity and Carcinogenicity of 4-Vinyl-1 -cyclohexene Diepoxide in Fischer Rats and B6C3F1 Mice

1990 ◽  
Vol 14 (4) ◽  
pp. 752-763
Author(s):  
R. S. CHHABRA ◽  
JAMES HUFF ◽  
J. HASEMAN ◽  
M. P. JOKJNEN ◽  
M. HETJMANCIK
Keyword(s):  
Dermal Toxicity ◽  
B6c3f1 Mice ◽  
Fischer Rats

Reactivity of Pulmonary Alveolar Cells to Crocidolite Asbestos Fibers

1982 ◽  
Vol 40 ◽  
pp. 334-335
Author(s):  
Charles L. Sanders ◽  
Roy R. Adee
Keyword(s):  
Osmium Tetroxide ◽  
Intratracheal Instillation ◽  
Uranyl Acetate ◽  
Fiber Suspension ◽  
Nacl Solution ◽  
Alveolar Cells ◽  
Asbestos Fibers ◽  
Fischer Rats ◽  
Mineral Silicates

Asbestos is a generic name for a group of hydrated mineral silicates that occur naturally in a fibrous form. The early interactions of asbestos fibers with alveolar cells in large part determines their long-term toxicity. Young adult, SPF, Fischer rats were given a single intratracheal instillation of 2 mg crocidolite asbestos suspended in 0.5 ml of 0.9% NaCl solution. About 80% of the fibers had lengths of less than 10 ym as measured on light micrographs of the fiber suspension. Two rats were killed at 3 hr, 1 d and 1, 4, 8, 12 and 16 wk after instillation and the lungs instilled with 8 ml McDowell - Trumps at 20 cm H2O. Lung tissue was dehydrated and sputtered coated with palladium-gold for SEM or post-fixed in osmium tetroxide, embedded in epoxy resin and sections stained with uranyl acetate and lead citrate for TEM.

Thirteen-week toxicology studies of 1-amino-2,4-dibromoanthraquinone in Fischer 344N rats and B6C3F1 mice

1986 ◽  
Vol 82 (3) ◽  
pp. 389-404 ◽  
Author(s):  
Robert W. Fleischman ◽  
Henry J. Esber ◽  
Miasnig Hagopian ◽  
Herman S. Lilja ◽  
James Huff
Keyword(s):  
B6c3f1 Mice
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