Comparative Pharmacology and Structure–Activity Relationships of D1 Dopamine Receptor Positive Allosteric Modulators

Structure Activity ◽

D1 Dopamine Receptor ◽

Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites

Molecular Pharmacology ◽

10.1124/mol.118.113175 ◽

2018 ◽

Vol 94 (4) ◽

pp. 1197-1209 ◽

Cited By ~ 13

Author(s):

Kathryn D. Luderman ◽

Jennie L. Conroy ◽

R. Benjamin Free ◽

Noel Southall ◽

Marc Ferrer ◽

...

Keyword(s):

Dopamine Receptor ◽

Binding Sites ◽

Allosteric Modulators ◽

D1 Dopamine Receptor ◽

Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure–Activity Relationships and Assessment in a Rat Model of Nicotine Dependence

Journal of Medicinal Chemistry ◽

10.1021/jm3005306 ◽

2012 ◽

Vol 55 (22) ◽

pp. 9434-9445 ◽

Cited By ~ 20

Author(s):

Shyama Sidique ◽

Raveendra-Panickar Dhanya ◽

Douglas J. Sheffler ◽

Hilary Highfield Nickols ◽

Li Yang ◽

...

Keyword(s):

Nicotine Dependence ◽

Rat Model ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Structure Activity ◽

Positive Allosteric Modulators ◽

Orally Active

Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)AReceptor: Structure–Activity Relationships of Heterocyclic Substitution at C-21

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b00032 ◽

2015 ◽

Vol 58 (8) ◽

pp. 3500-3511 ◽

Cited By ~ 22

Author(s):

Gabriel Martinez Botella ◽

Francesco G. Salituro ◽

Boyd L. Harrison ◽

Richard T. Beresis ◽

Zhu Bai ◽

...

Keyword(s):

Neuroactive Steroids ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Structure Activity ◽

Faculty Opinions recommendation of Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure-Activity Relationships of Heterocyclic Substitution at C-21.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725400346.793505485 ◽

2015 ◽

Author(s):

John Lowe

Keyword(s):

Neuroactive Steroids ◽

Aminobutyric Acid ◽

Allosteric Modulators ◽

Receptor Structure ◽

Structure Activity ◽

Structure–Activity Relationships of Pan-Gαq/11 Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.8b00136 ◽

2018 ◽

Vol 9 (7) ◽

pp. 1818-1828 ◽

Cited By ~ 3

Author(s):

Alice E. Berizzi ◽

Aaron M. Bender ◽

Craig W. Lindsley ◽

P. Jeffrey Conn ◽

Patrick M. Sexton ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Structure Activity ◽

Development of pyrimidone D1 dopamine receptor positive allosteric modulators

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2020.127696 ◽

2021 ◽

Vol 31 ◽

pp. 127696

Author(s):

Kathryn D. Luderman ◽

Prashi Jain ◽

R. Benjamin Free ◽

Jennie L. Conroy ◽

Jeffrey Aubé ◽

...

Keyword(s):

Dopamine Receptor ◽

Allosteric Modulators ◽

D1 Dopamine Receptor ◽

A novel class of positive allosteric modulators of AMPA receptors: Design, synthesis, and structure–activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.07.012 ◽

2006 ◽

Vol 16 (19) ◽

pp. 5203-5206 ◽

Cited By ~ 11

Author(s):

Hamideh Zarrinmayeh ◽

Eric Tromiczak ◽

Dennis M. Zimmerman ◽

Nancy Rankl ◽

Ken H. Ho ◽

...

Keyword(s):

Carboxylic Acid ◽

Ampa Receptors ◽

Allosteric Modulators ◽

Design Synthesis ◽

Structure Activity ◽

Discovery and structure-activity relationships study of positive allosteric modulators of the M3 muscarinic acetylcholine receptor

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2020.115531 ◽

2020 ◽

Vol 28 (13) ◽

pp. 115531

Author(s):

Hiroaki Tanaka ◽

Kenji Negoro ◽

Takanori Koike ◽

Issei Tsukamoto ◽

Kazuhiro Yokoyama ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

M3 Muscarinic Acetylcholine Receptor ◽

Structure Activity ◽

Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.115.224071 ◽

2015 ◽

Vol 354 (3) ◽

pp. 340-349 ◽

Cited By ~ 22

Author(s):

Martin A. Lewis ◽

Lisa Hunihan ◽

John Watson ◽

Robert G. Gentles ◽

Shuanghua Hu ◽

...

Keyword(s):

Dopamine Receptor ◽

Allosteric Modulators ◽

Species Selectivity ◽

D1 Dopamine Receptor ◽

4H-1,2,4-Pyridothiadiazine 1,1-Dioxides and 2,3-Dihydro-4H-1,2,4-pyridothiadiazine 1,1-Dioxides Chemically Related to Diazoxide and Cyclothiazide as Powerful Positive Allosteric Modulators of (R/S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors: Design, Synthesis, Pharmacology, and Structure−Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm970694v ◽

1998 ◽

Vol 41 (16) ◽

pp. 2946-2959 ◽

Cited By ~ 44

Author(s):

Bernard Pirotte ◽

Tchao Podona ◽

Ousmane Diouf ◽

Pascal de Tullio ◽

Philippe Lebrun ◽

...

Keyword(s):

Propionic Acid ◽

Allosteric Modulators ◽

Design Synthesis ◽

Structure Activity ◽