scholarly journals Effects of the Anticancer Drug Doxorubicin and Dietary Creatine Supplementation on Myogenic Regulatory Factor Expression

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Raquel B Busekrus ◽  
Zoltan A Torok ◽  
David S Hydock
2020 ◽  
Vol 52 (7S) ◽  
pp. 910-910
Author(s):  
Ryan A. Gordon ◽  
Gena D. Guerin ◽  
Emily L. Zumbro ◽  
Chase M. White ◽  
Dreanna M. McAdams ◽  
...  

animal ◽  
2016 ◽  
Vol 10 (7) ◽  
pp. 1200-1203 ◽  
Author(s):  
J.S. Raja ◽  
M.L. Hoffman ◽  
K.E. Govoni ◽  
S.A. Zinn ◽  
S.A. Reed

1993 ◽  
Vol 265 (1) ◽  
pp. E176-E178 ◽  
Author(s):  
C. A. Maltin ◽  
M. I. Delday ◽  
G. P. Campbell ◽  
J. E. Hesketh

The amelioration of denervation atrophy by the beta-adrenoceptor agonist clenbuterol has led to the suggestion that the drug mimics or stimulates production of neurotrophic factors. Neurotrophic factors have profound effects on muscle growth, but the precise mechanisms through which this influence is exerted are unknown. The expression of myoD and myogenin, proteins that in turn regulate the transcription of tissue-specific genes during skeletal muscle differentiation, is controlled by innervation. In muscle undergoing denervation-induced atrophy, myoD and myogenin mRNAs increase. However, this is only partially reversed by electrical activity, thus implicating neurotrophic factors in regulation of these genes. Here we demonstrate that clenbuterol represses myoD and myogenin expression and decreases the levels of acetylcholine receptors in denervated muscles. The data provide the first evidence that the action of clenbuterol is directed through the neural axis.


Development ◽  
2012 ◽  
Vol 139 (5) ◽  
pp. 958-967 ◽  
Author(s):  
N. Moncaut ◽  
J. W. Cross ◽  
C. Siligan ◽  
A. Keith ◽  
K. Taylor ◽  
...  

2009 ◽  
Vol 80 (6) ◽  
pp. 678-685 ◽  
Author(s):  
Susumu MUROYA ◽  
Kouichi WATANABE ◽  
Shinichiro HAYASHI ◽  
Masato MIYAKE ◽  
Shigeru KONASHI ◽  
...  

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