scholarly journals Measurement of the Induction of the 4977‐bp Common Deletion in Human Mitochondrial DNA by Gamma Radiation Using Real‐time PCR

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Michael Miller ◽  
Jessica Gucwa ◽  
Robert O'Donnell ◽  
Wendy Pogozelski
Keyword(s):  
Mitochondrial Dna ◽  
Gamma Radiation ◽  
Real Time ◽  
Real Time Pcr ◽  
Human Mitochondrial Dna ◽  
Common Deletion

scholarly journals Common Deletion (CD) in mitochondrial DNA of irradiated rat heart

2014 ◽  
Vol 86 (2) ◽  
pp. 685-694 ◽  
Author(s):  
RAQUEL G. SIQUEIRA ◽  
DAYSE A. DA SILVA ◽  
LUIZ D.B. DE MELO ◽  
ELIZEU F. DE CARVALHO ◽  
SAMARA C. FERREIRA-MACHADO ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Ionizing Radiation ◽  
Real Time ◽  
Real Time Pcr ◽  
Rat Heart ◽  
Wistar Rats ◽  
Post Irradiation ◽  
Male Wistar Rats ◽  
The Common ◽  
Common Deletion

The purpose of this study was to map the common deletion (CD) area in mtDNA and investigate the levels of this deletion in irradiated heart. The assays were developed in male Wistar rats that were irradiated with three different single doses (5, 10 or 15 Gy) delivered directly to the heart and the analyses were performed at various times post-irradiation (3, 15 or 120 days). The CDs area were sequenced and the CD quantified by real-time PCR. Our study demonstrated that the CD levels progressively decreased from the 3rduntil the 15th day after irradiation, and then increased thereafter. Additionally, it was observed that the levels of CD are modulated differently according to the different categories of doses (moderate and high). This study demonstrated an immediate response to ionizing radiation, measured by the presence of mutations in the CD area and a decrease in the CD levels.

Quantification of the 4977-bp deletion in human mitochondrial DNA using real-time PCR

2001 ◽  
Vol 122 (2-3) ◽  
pp. 197-198 ◽  
Author(s):  
Pamela Schinogl ◽  
Mathias Müller ◽  
Ralf Steinborn
Keyword(s):  
Mitochondrial Dna ◽  
Real Time ◽  
Real Time Pcr ◽  
Human Mitochondrial Dna

Quantification of human mitochondrial DNA in a real time PCR

2002 ◽  
Vol 126 (1) ◽  
pp. 34-39 ◽  
Author(s):  
N. von Wurmb-Schwark ◽  
R. Higuchi ◽  
A.P. Fenech ◽  
C. Elfstroem ◽  
C. Meissner ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Real Time ◽  
Real Time Pcr ◽  
Human Mitochondrial Dna

Singleplex quantitative real-time PCR for the assessment of human mitochondrial DNA quantity and quality

2018 ◽  
Vol 14 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Corey Goodwin ◽  
Denice Higgins ◽  
Shanan S. Tobe ◽  
Jeremy Austin ◽  
Andrew Wotherspoon ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Real Time ◽  
Real Time Pcr ◽  
Quantitative Real Time Pcr ◽  
Human Mitochondrial Dna

Internal Validation of Human Mitochondrial DNA Quantification Using Real-Time PCR

2014 ◽  
Vol 59 (4) ◽  
pp. 1049-1056 ◽  
Author(s):  
Marc L. Sprouse ◽  
Nicole R. Phillips ◽  
Mark F. Kavlick ◽  
Rhonda K. Roby
Keyword(s):  
Mitochondrial Dna ◽  
Real Time ◽  
Real Time Pcr ◽  
Dna Quantification ◽  
Internal Validation ◽  
Human Mitochondrial Dna

scholarly journals Detection and Quantification of Large Scale Deletions of Human Mitochondrial DNA by Real‐time PCR

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Edan Qian ◽  
Julie Xue ◽  
James M. Guo ◽  
Xueshan Gao ◽  
John W Eaton ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Real Time ◽  
Real Time Pcr ◽  
Large Scale ◽  
Human Mitochondrial Dna ◽  
Detection And Quantification

scholarly journals Quantitative analysis of human mitochondrial DNA using a real-time PCR assay

HIV Medicine ◽  
2003 ◽  
Vol 4 (3) ◽  
pp. 287-292 ◽  
Author(s):  
K Gourlain ◽  
B Amellal ◽  
Z Ait Arkoub ◽  
N Dupin ◽  
C Katlama ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Quantitative Analysis ◽  
Real Time ◽  
Real Time Pcr ◽  
Pcr Assay ◽  
Human Mitochondrial Dna
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