Characterization of novel selective positive allosteric modulators (PAMS) of the M4 muscarinic acetylcholine receptor (mAChR)

Ashley Elizabeth Brady; Tom M Bridges; Carrie K Jones; Jana K Shirey; Craig W Lindsley; P Jeffrey Conn

doi:10.1096/fasebj.22.1_supplement.714.2

Characterization of novel selective positive allosteric modulators (PAMS) of the M4 muscarinic acetylcholine receptor (mAChR)

The FASEB Journal ◽

10.1096/fasebj.22.1_supplement.714.2 ◽

2008 ◽

Vol 22 (S1) ◽

Author(s):

Ashley Elizabeth Brady ◽

Tom M Bridges ◽

Carrie K Jones ◽

Jana K Shirey ◽

Craig W Lindsley ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Positive Allosteric Modulators

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Surface modified nano-lipid drug conjugates of positive allosteric modulators of M1 muscarinic acetylcholine receptor for the treatment of Alzheimer’s disease

Medical Hypotheses ◽

10.1016/j.mehy.2017.01.026 ◽

2017 ◽

Vol 101 ◽

pp. 17-22 ◽

Cited By ~ 3

Author(s):

Pavan Kumar Chintamaneni ◽

Praveen T. Krishnamurthy ◽

Pachava Vengal Rao ◽

SaiKiran S.S. Pindiprolu

Keyword(s):

Alzheimer’S Disease ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Drug Conjugates ◽

Positive Allosteric Modulators ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic ◽

Surface Modified

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Discovery of a Novel Class of Heteroaryl-Pyrrolidinones as Positive Allosteric Modulators of the Muscarinic Acetylcholine Receptor M1

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2021.128193 ◽

2021 ◽

pp. 128193

Author(s):

Paul K. Spearing ◽

Hyekyung P. Cho ◽

Vincent B. Luscombe ◽

Anna L. Blobaum ◽

Olivier Boutaud ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Positive Allosteric Modulators

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Faculty Opinions recommendation of Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732691118.793543578 ◽

2018 ◽

Author(s):

Robert Copeland

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Positive Allosteric Modulators

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Development of Novel 4‐Arylpyridin‐2‐one and 6‐Arylpyrimidin‐4‐one Positive Allosteric Modulators of the M 1 Muscarinic Acetylcholine Receptor

ChemMedChem ◽

10.1002/cmdc.202000540 ◽

2020 ◽

Author(s):

Manuela Jörg ◽

Elham Khajehali ◽

Emma T. Westhuizen ◽

K. H. C. Choy ◽

David M. Shackleford ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Positive Allosteric Modulators

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Structure–Activity Relationships of Pan-Gαq/11 Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.8b00136 ◽

2018 ◽

Vol 9 (7) ◽

pp. 1818-1828 ◽

Cited By ~ 3

Author(s):

Alice E. Berizzi ◽

Aaron M. Bender ◽

Craig W. Lindsley ◽

P. Jeffrey Conn ◽

Patrick M. Sexton ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Structure Activity Relationships ◽

Structure Activity ◽

Positive Allosteric Modulators

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Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

Biochemical Pharmacology ◽

10.1016/j.bcp.2018.05.009 ◽

2018 ◽

Vol 154 ◽

pp. 243-254 ◽

Cited By ~ 8

Author(s):

Elham Khajehali ◽

Celine Valant ◽

Manuela Jörg ◽

Andrew B. Tobin ◽

P. Jeffrey Conn ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Positive Allosteric Modulators ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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Effects of M1 and M4 muscarinic acetylcholine receptor positive allosteric modulators on sleep and cognition in rodents

The FASEB Journal ◽

10.1096/fasebj.27.1_supplement.661.8 ◽

2013 ◽

Vol 27 (S1) ◽

Author(s):

Robert W Gould ◽

Michael T Nedelcovych ◽

Michael D Grannan ◽

Michael Bubser ◽

Michael R Wood ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Positive Allosteric Modulators ◽

Sleep And Cognition

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P2-068: CIRCADIAN RHYTHM-DEPENDENT EFFECTS OF M1 MUSCARINIC ACETYLCHOLINE RECEPTOR POSITIVE ALLOSTERIC MODULATORS ON AROUSAL AND COGNITION

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.2475 ◽

2019 ◽

Vol 15 ◽

pp. P596-P597

Author(s):

Jason K. Russell ◽

Robert W. Gould ◽

Michael Bubser ◽

Richard J. Fu ◽

Nina Norman ◽

...

Keyword(s):

Circadian Rhythm ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Positive Allosteric Modulators ◽

M1 Muscarinic Acetylcholine Receptor ◽

M1 Muscarinic

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Age and circadian rhythm‐dependent effects of M 1 muscarinic acetylcholine receptor positive allosteric modulators and donepezil on sleep‐wake architecture and arousal

Alzheimer s & Dementia ◽

10.1002/alz.057851 ◽

2021 ◽

Vol 17 (S9) ◽

Author(s):

Jason K Russell ◽

Michael Bubser ◽

Paul A Newhouse ◽

Craig W Lindsley ◽

Carrie K Jones

Keyword(s):

Circadian Rhythm ◽

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Positive Allosteric Modulators

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Discovery and structure-activity relationships study of positive allosteric modulators of the M3 muscarinic acetylcholine receptor

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2020.115531 ◽

2020 ◽

Vol 28 (13) ◽

pp. 115531

Author(s):

Hiroaki Tanaka ◽

Kenji Negoro ◽

Takanori Koike ◽

Issei Tsukamoto ◽

Kazuhiro Yokoyama ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Muscarinic Acetylcholine ◽

Structure Activity Relationships ◽

M3 Muscarinic Acetylcholine Receptor ◽

Structure Activity ◽

Positive Allosteric Modulators

Download Full-text