Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

Allosteric Modulators ◽

Surface modified nano-lipid drug conjugates of positive allosteric modulators of M1 muscarinic acetylcholine receptor for the treatment of Alzheimer’s disease

Medical Hypotheses ◽

10.1016/j.mehy.2017.01.026 ◽

2017 ◽

Vol 101 ◽

pp. 17-22 ◽

Cited By ~ 3

Author(s):

Pavan Kumar Chintamaneni ◽

Praveen T. Krishnamurthy ◽

Pachava Vengal Rao ◽

SaiKiran S.S. Pindiprolu

Keyword(s):

Alzheimer’S Disease ◽

Acetylcholine Receptor ◽

Allosteric Modulators ◽

Drug Conjugates ◽

M1 Muscarinic ◽

Surface Modified

P2-068: CIRCADIAN RHYTHM-DEPENDENT EFFECTS OF M1 MUSCARINIC ACETYLCHOLINE RECEPTOR POSITIVE ALLOSTERIC MODULATORS ON AROUSAL AND COGNITION

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.2475 ◽

2019 ◽

Vol 15 ◽

pp. P596-P597

Author(s):

Jason K. Russell ◽

Robert W. Gould ◽

Michael Bubser ◽

Richard J. Fu ◽

Nina Norman ◽

...

Keyword(s):

Circadian Rhythm ◽

Acetylcholine Receptor ◽

Allosteric Modulators ◽

Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b01812 ◽

2018 ◽

Vol 61 (7) ◽

pp. 2875-2894 ◽

Cited By ~ 6

Author(s):

Juliana C. C. Dallagnol ◽

Elham Khajehali ◽

Emma T. van der Westhuizen ◽

Manuela Jörg ◽

Celine Valant ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Allosteric Modulators ◽

Agonist Activity ◽

Pharmacological Evaluation ◽

Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.6b00018 ◽

2016 ◽

Vol 7 (5) ◽

pp. 647-661 ◽

Cited By ~ 10

Author(s):

Shailesh N. Mistry ◽

Herman Lim ◽

Manuela Jörg ◽

Ben Capuano ◽

Arthur Christopoulos ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Allosteric Modulators ◽

Identification of Candidate Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor Which May Improve Vagus Nerve Stimulation in Chronic Tinnitus

Frontiers in Neuroscience ◽

10.3389/fnins.2017.00636 ◽

2017 ◽

Vol 11 ◽

Cited By ~ 3

Author(s):

Tijana Bojić ◽

Vladimir R. Perović ◽

Milan Senćanski ◽

Sanja Glišić

Keyword(s):

Vagus Nerve ◽

Acetylcholine Receptor ◽

Nerve Stimulation ◽

Vagus Nerve Stimulation ◽

Chronic Tinnitus ◽

Allosteric Modulators ◽

5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated Galpha(q) signalling in patients with psychiatric disorders

10.26226/morressier.5b68175eb56e9b005965c3a3 ◽

2018 ◽

Author(s):

Yuji Odagaki

Keyword(s):

Psychiatric Disorders ◽

Acetylcholine Receptor ◽

5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated activation of Gαq/11 in postmortem dorsolateral prefrontal cortex of opiate addicts

Pharmacological Reports ◽

10.1007/s43440-021-00248-w ◽

2021 ◽

Author(s):

Yuji Odagaki ◽

Masakazu Kinoshita ◽

J. Javier Meana ◽

Luis F. Callado ◽

Jesús A. García-Sevilla

Keyword(s):

Prefrontal Cortex ◽

Acetylcholine Receptor ◽

Dorsolateral Prefrontal Cortex ◽

Dorsolateral Prefrontal ◽

Opiate Addicts ◽

Pharmacological Assessment of M1 Muscarinic Acetylcholine Receptor-Gq/11 Protein Coupling in Membranes Prepared from Postmortem Human Brain Tissue

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.108.137968 ◽

2008 ◽

Vol 325 (3) ◽

pp. 869-874 ◽

Cited By ~ 20

Author(s):

Hasib Salah-Uddin ◽

David R. Thomas ◽

Ceri H. Davies ◽

Jim J. Hagan ◽

Martyn D. Wood ◽

...

Keyword(s):

Human Brain ◽

Brain Tissue ◽

Acetylcholine Receptor ◽

Human Brain Tissue ◽

Postmortem Human Brain ◽

Protein Coupling ◽

Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand‐binding affinity and signal transduction

The FASEB Journal ◽

10.1096/fj.201800936r ◽

2018 ◽

Vol 33 (3) ◽

pp. 3237-3251 ◽

Cited By ~ 3

Author(s):

Jianrong Xu ◽

Panpan Tan ◽

Hui Li ◽

Yongyao Cui ◽

Yu Qiu ◽

...

Keyword(s):

Signal Transduction ◽

Ligand Binding ◽

Binding Affinity ◽

Acetylcholine Receptor ◽

The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity

The EMBO Journal ◽

10.1093/emboj/16.15.4597 ◽

1997 ◽

Vol 16 (15) ◽

pp. 4597-4605 ◽

Cited By ~ 144

Author(s):

W. Tsai

Keyword(s):

Ion Channel ◽

Acetylcholine Receptor ◽

Egf Receptor ◽

Channel Activity ◽