scholarly journals Electrical Stimulation of Carotid Sinus in Conscious Normotensive and Spontaneously Hypertensive Rats

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Gean Domingos ◽  
Fernanda Santos‐Almeida ◽  
Luiz Eduardo Silva ◽  
Daniel Dias ◽  
Carlos Alberto Silva ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Spontaneously Hypertensive Rats ◽  
Carotid Sinus ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Stimulation Of

Diminished sympathetic silent period in spontaneously hypertensive rats

1979 ◽  
Vol 236 (3) ◽  
pp. R147-R152 ◽  
Author(s):  
L. P. Schramm ◽  
G. N. Barton
Keyword(s):  
Electrical Stimulation ◽  
Sympathetic Activity ◽  
Spontaneously Hypertensive Rats ◽  
Silent Period ◽  
Spontaneous Hypertension ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Splanchnic Nerves ◽  
Wistar Kyoto ◽  
Stimulation Of

To determine if elevated sympathetic activity occurs in spontaneously hypertension, the silent period induced in splanchnic nerves following electrical stimulation of dorsal medullary sympathoexcitatory sites was compared in anesthetized normotensive Wistar Kyoto rats (WKYs) and Okamoto spontaneously hypertensive rats (SHRs). The strength of silent periods was defined as the degree of inhibition of responses to testing stimuli delivered at various latencies following conditioning trains, and it was assumed to be inversely related to the level of sympathetic activity. Weanling SHRs exhibited weaker silent periods than weanling WKYs although, at that age, the arterial pressures of the strains were not significantly different. Silent periods were also weaker in adult SHRs than in adult WKYs. This difference persisted after arterial pressures, which fell under anesthesia, were raised by phenylephrine infusions to the respective "normal" levels in each strain. These results support the hypothesis that elevated sympathetic activity exists during both the development and maintenance of spontaneous hypertension in rats.

Erectile dysfunction in spontaneously hypertensive rats: pathophysiological mechanisms

2003 ◽  
Vol 284 (3) ◽  
pp. R682-R688 ◽  
Author(s):  
Delphine Behr-Roussel ◽  
Philippe Chamiot-Clerc ◽  
Jacques Bernabe ◽  
Katell Mevel ◽  
Laurent Alexandre ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Electrical Stimulation ◽  
Erectile Dysfunction ◽  
Spontaneously Hypertensive Rats ◽  
Isometric Tension ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto ◽  
Stimulation Of

Hypertensive men have a higher prevalence of erectile dysfunction (ED) than the general population. Experimental evidence of ED in hypertensive animals is scarce. This study evaluates the erectile function of spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) in vivo by the increase in intracavernosal pressure after electrical stimulation of the cavernous nerve (CN) and by isometric tension studies on corporal strips. Frequency-dependent erectile responses to CN stimulations were reduced in SHR. Phenylephrine induced lower corporal contractions in SHR although pD2 values were similar to WKY. Endothelium-dependent relaxations to ACh were impaired significantly in SHR, and indomethacin improved these relaxations in both WKY and SHR, the latter thus reaching values similar to WKY. Corporal relaxations to sodium nitroprusside were enhanced in SHR. Thus a dysfunctional α-adrenergic contraction of the corporal smooth muscle, an increased cyclooxygenase-dependent constrictor tone, and/or a defect in endothelium-dependent reactivity are associated with the altered erectile mechanisms in SHR. Drugs targeting endothelial dysfunction may delay the occurrence of ED as a complication of hypertension.

Stimulation of brain cannabinoid CB 1 receptors can ameliorate hypertension in spontaneously hypertensive rats

2020 ◽  
Vol 47 (7) ◽  
pp. 1254-1262
Author(s):  
Takahiro Shimizu ◽  
Masaki Yamamoto ◽  
Suo Zou ◽  
Shogo Shimizu ◽  
Youichirou Higashi ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Stimulation Of

scholarly journals Role of cholinergic receptors in adrenal catecholamine secretion in spontaneously hypertensive rats

1999 ◽  
Vol 277 (4) ◽  
pp. R1057-R1062 ◽  
Author(s):  
Takahiro Nagayama ◽  
Takayuki Matsumoto ◽  
Makoto Yoshida ◽  
Mizue Suzuki-Kusaba ◽  
Hiroaki Hisa ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Muscarinic Receptors ◽  
Nicotinic Receptors ◽  
Spontaneously Hypertensive Rats ◽  
Adrenal Glands ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Wky Rats ◽  
Wistar Kyoto

We investigated the role of nicotinic and muscarinic receptors in secretion of catecholamines induced by transmural electrical stimulation (ES) from isolated perfused adrenal glands of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats. ES (1–10 Hz) produced frequency-dependent increases in epinephrine (Epi) and norepinephrine (NE) output as measured in perfusate. The ES-induced increases in NE output, but not Epi output, were significantly greater in adrenal glands of SHRs than in those of WKY rats. Hexamethonium (10–100 μM) markedly inhibited the ES-induced increases in Epi and NE output from adrenal glands of SHRs and WKY rats. Atropine (0.3–3 μM) inhibited the ES-induced increases in Epi and NE output from adrenal glands of SHRs, but not from those of WKY rats. These results suggest that endogenous acetylcholine-induced secretion of adrenal catecholamines is predominantly mediated by nicotinic receptors in SHRs and WKY rats and that the contribution of muscarinic receptors may be different between these two strains.

791 CAROTID SINUS NERVE ABLATION IN ADULT SPONTANEOUSLY HYPERTENSIVE RATS (SHR) IS CHRONICALLY ANTI-HYPERTENSIVE

2012 ◽  
Vol 30 ◽  
pp. e229
Author(s):  
Fiona D. McBryde ◽  
Ana P.L. Abdala ◽  
Alex V. Gourine ◽  
Nepthali Marina ◽  
Emma B. Hendy ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Carotid Sinus ◽  
Carotid Sinus Nerve ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals The somato-sympathetic reflex in the spontaneous hypertensive rats

2003 ◽  
Vol 9 (3) ◽  
pp. 102-106
Author(s):  
Yu. I. Shcherbin ◽  
R. S. Khrustaleva ◽  
V. A. Cirlin
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Silent Period ◽  
Hypertensive Rats ◽  
Electrical Shock ◽  
Spontaneously Hypertensive ◽  
Shock Amplitude ◽  
Somatosympathetic Reflex ◽  
Cervical Sympathetic ◽  
Myelinated Fibres ◽  
Stimulation Of

In chloralose anesthetized and paralyzed spontaneously hypertensive rats (SHR) a somatosympathetic reflex in the cervical sympathetic trunk elicited by a single electrical shock to forelimb afferent fibres in the median nerve was recorded. It has been shown that the somatosympathetic reflex consists of two responses and following silent period. The А-response evoked by the somatic myelinated afferent fibres stimulation, and C-respon.se elicited by the both stimulation of myelinated and unmyelinated afferent fibres. The silent period occurred with the myelinated fibres stimulation. Its duration was proportional to the electrical shock amplitude. The А-response consisted of four waves, the three of them formed early and late responses.

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