scholarly journals Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats

2010 ◽  
Vol 159 (3) ◽  
pp. 709-716 ◽  
Author(s):  
S Bosnyak ◽  
IK Welungoda ◽  
A Hallberg ◽  
M Alterman ◽  
RE Widdop ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Compound 21 ◽  
Peptide Agonist ◽  
Stimulation Of ◽  
At2 Receptors

Stimulation of brain cannabinoid CB 1 receptors can ameliorate hypertension in spontaneously hypertensive rats

2020 ◽  
Vol 47 (7) ◽  
pp. 1254-1262
Author(s):  
Takahiro Shimizu ◽  
Masaki Yamamoto ◽  
Suo Zou ◽  
Shogo Shimizu ◽  
Youichirou Higashi ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Stimulation Of

scholarly journals The somato-sympathetic reflex in the spontaneous hypertensive rats

2003 ◽  
Vol 9 (3) ◽  
pp. 102-106
Author(s):  
Yu. I. Shcherbin ◽  
R. S. Khrustaleva ◽  
V. A. Cirlin
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Silent Period ◽  
Hypertensive Rats ◽  
Electrical Shock ◽  
Spontaneously Hypertensive ◽  
Shock Amplitude ◽  
Somatosympathetic Reflex ◽  
Cervical Sympathetic ◽  
Myelinated Fibres ◽  
Stimulation Of

In chloralose anesthetized and paralyzed spontaneously hypertensive rats (SHR) a somatosympathetic reflex in the cervical sympathetic trunk elicited by a single electrical shock to forelimb afferent fibres in the median nerve was recorded. It has been shown that the somatosympathetic reflex consists of two responses and following silent period. The А-response evoked by the somatic myelinated afferent fibres stimulation, and C-respon.se elicited by the both stimulation of myelinated and unmyelinated afferent fibres. The silent period occurred with the myelinated fibres stimulation. Its duration was proportional to the electrical shock amplitude. The А-response consisted of four waves, the three of them formed early and late responses.

Diminished sympathetic silent period in spontaneously hypertensive rats

1979 ◽  
Vol 236 (3) ◽  
pp. R147-R152 ◽  
Author(s):  
L. P. Schramm ◽  
G. N. Barton
Keyword(s):  
Electrical Stimulation ◽  
Sympathetic Activity ◽  
Spontaneously Hypertensive Rats ◽  
Silent Period ◽  
Spontaneous Hypertension ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Splanchnic Nerves ◽  
Wistar Kyoto ◽  
Stimulation Of

To determine if elevated sympathetic activity occurs in spontaneously hypertension, the silent period induced in splanchnic nerves following electrical stimulation of dorsal medullary sympathoexcitatory sites was compared in anesthetized normotensive Wistar Kyoto rats (WKYs) and Okamoto spontaneously hypertensive rats (SHRs). The strength of silent periods was defined as the degree of inhibition of responses to testing stimuli delivered at various latencies following conditioning trains, and it was assumed to be inversely related to the level of sympathetic activity. Weanling SHRs exhibited weaker silent periods than weanling WKYs although, at that age, the arterial pressures of the strains were not significantly different. Silent periods were also weaker in adult SHRs than in adult WKYs. This difference persisted after arterial pressures, which fell under anesthesia, were raised by phenylephrine infusions to the respective "normal" levels in each strain. These results support the hypothesis that elevated sympathetic activity exists during both the development and maintenance of spontaneous hypertension in rats.

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