CLINICAL CORRELATES OF BENZODIAZEPINE RECEPTOR FUNCTION

1992 ◽  
Vol 15 ◽  
pp. 679A-680A ◽  
Author(s):  
D. J. NUTT ◽  
P. GLUE ◽  
S. WILSON ◽  
N. COUPLAND ◽  
A. LILLYWHITE
Keyword(s):  
Benzodiazepine Receptor ◽  
Receptor Function ◽  
Clinical Correlates

Naloxone antagonizes GABA A /benzodiazepine receptor function in rat corticohippocampal synaptoneurosomes

2000 ◽  
Vol 107 (3) ◽  
pp. 261-270 ◽  
Author(s):  
A. I. Svensson ◽  
A. Berntsson ◽  
M. Eirefelt ◽  
B. Söderpalm
Keyword(s):  
Benzodiazepine Receptor ◽  
Receptor Function ◽  
Gaba A

An allosteric model for benzodiazepine receptor function

1983 ◽  
Vol 32 (16) ◽  
pp. 2375-2383 ◽  
Author(s):  
Frederick J. Ehlert ◽  
William R. Roeske ◽  
Kelvin W. Gee ◽  
Henry I. Yamamura
Keyword(s):  
Benzodiazepine Receptor ◽  
Receptor Function ◽  
Allosteric Model

In vivo modulation of benzodiazepine receptor function after inhibition of endogenous γ-aminobutyric acid synthesis

1997 ◽  
Vol 321 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Michel Bottlaender ◽  
Lorenz Schmid ◽  
Chantal Fuseau ◽  
Denis Fournier ◽  
Emmanuel Brouillet ◽  
...  
Keyword(s):  
Benzodiazepine Receptor ◽  
Acid Synthesis ◽  
Aminobutyric Acid ◽  
Receptor Function

Investigating benzodiazepine receptor function in vivo using an intravenous infusion of DMCM

1984 ◽  
Vol 103 (3-4) ◽  
pp. 359-362 ◽  
Author(s):  
David J. Nutt ◽  
Hilary J. Little ◽  
Stuart C. Taylor ◽  
Michael C.W. Minchin
Keyword(s):  
Intravenous Infusion ◽  
Benzodiazepine Receptor ◽  
Receptor Function

scholarly journals Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy

2004 ◽  
Vol 13 (2) ◽  
pp. 93-103 ◽  
Author(s):  
Marcelo Barreto Spillere da Silva ◽  
Roseli Coimbra Farges ◽  
Tânia Silvia Fröde
Keyword(s):  
Nitric Oxide ◽  
Adenosine Deaminase ◽  
Benzodiazepine Receptor ◽  
Peripheral Benzodiazepine Receptor ◽  
Receptor Function ◽  
Anti Inflammatory ◽  
Pre Treatment ◽  
Inflammatory Action ◽  
Inflammatory Effect

BACKGROUND: Studies on peripheral benzodiazepine receptor function have yielded a diverse list of activities of which the anti-inflammatory effects need to be further examined.Aims: To evaluate the role of steroids, nitric oxide and adenosine-deaminase in the anti-inflammatory effect of PK11195.Methods: Pleurisy was induced by intrapleural injection of carrageenan in mice pre-treated or not with PK11195. Leukocytes, exudation, adenosine-deaminase (ADA) activity and nitric oxide (NO) level were measured. Steroid involvement was evaluated by pre-treatment with D,L-aminogluthetimide before PK11195.Results: Leukocytes, exudation and NO levels were reduced by PK11195 in the early (4 h) phase. In the late (48 h) phase, PK11195 decreased leukocytes and ADA activity. D,L-aminogluthetimide reversed the effect of PK11195 on exudate (4 h), as well as total and differential leukocytes and NO levels (48 h).Conclusions: Steroids, NO and ADA are implicated in the anti-inflammatory action of PK11195.

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