In vivo modulation of benzodiazepine receptor function after inhibition of endogenous γ-aminobutyric acid synthesis

1997 ◽  
Vol 321 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Michel Bottlaender ◽  
Lorenz Schmid ◽  
Chantal Fuseau ◽  
Denis Fournier ◽  
Emmanuel Brouillet ◽  
...  
Keyword(s):  
Benzodiazepine Receptor ◽  
Acid Synthesis ◽  
Aminobutyric Acid ◽  
Receptor Function

Investigating benzodiazepine receptor function in vivo using an intravenous infusion of DMCM

1984 ◽  
Vol 103 (3-4) ◽  
pp. 359-362 ◽  
Author(s):  
David J. Nutt ◽  
Hilary J. Little ◽  
Stuart C. Taylor ◽  
Michael C.W. Minchin
Keyword(s):  
Intravenous Infusion ◽  
Benzodiazepine Receptor ◽  
Receptor Function

Importance of Glutamine for ?-Aminobutyric Acid Synthesis in Rat Neostriatum In Vivo

1988 ◽  
Vol 51 (4) ◽  
pp. 1294-1299 ◽  
Author(s):  
R. E. Paulsen ◽  
E. Odden ◽  
F. Fonnum
Keyword(s):  
Acid Synthesis ◽  
Aminobutyric Acid

scholarly journals E3 ubiquitin ligase Grail promotes hepatic steatosis through Sirt1 inhibition

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Pei-Yao Liu ◽  
Cheng-Cheung Chen ◽  
Chia-Ying Chin ◽  
Te-Jung Liu ◽  
Wen-Chiuan Tsai ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Lipid Accumulation ◽  
Acid Synthesis ◽  
Sirtuin 1 ◽  
Nonalcoholic Fatty Liver ◽  
Expression Of Genes ◽  
Hepatic Fat ◽  
Underlying Mechanisms

AbstractIn obese adults, nonalcoholic fatty liver disease (NAFLD) is accompanied by multiple metabolic dysfunctions. Although upregulated hepatic fatty acid synthesis has been identified as a crucial mediator of NAFLD development, the underlying mechanisms are yet to be elucidated. In this study, we reported upregulated expression of gene related to anergy in lymphocytes (GRAIL) in the livers of humans and mice with hepatic steatosis. Grail ablation markedly alleviated the high-fat diet-induced hepatic fat accumulation and expression of genes related to the lipid metabolism, in vitro and in vivo. Conversely, overexpression of GRAIL exacerbated lipid accumulation and enhanced the expression of lipid metabolic genes in mice and liver cells. Our results demonstrated that Grail regulated the lipid accumulation in hepatic steatosis via interaction with sirtuin 1. Thus, Grail poses as a significant molecular regulator in the development of NAFLD.

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