Factor VII deficiency and cardiac surgery

2004 ◽  
Vol 21 (Supplement 32) ◽  
pp. 84-85
Author(s):  
T. Tuna ◽  
J. Massaut ◽  
P. Wauthy ◽  
S. Beckers
1993 ◽  
Vol 23 (1) ◽  
pp. 65-68 ◽  
Author(s):  
A. Ferster ◽  
V. Capouet ◽  
A. Deville ◽  
P. Fondu ◽  
F. Corazza

2012 ◽  
Vol 26 (4) ◽  
pp. 651-653 ◽  
Author(s):  
Antonio Pérez-Ferrer ◽  
Elena Gredilla ◽  
Jesús de Vicente ◽  
Yolanda Laporta

2017 ◽  
Vol 27 (1) ◽  
pp. 42-44
Author(s):  
Fayaz Mohammed Khazi ◽  
Nayyer R Siddiqi ◽  
Yehia M Karaly ◽  
Bassil Al-Zamkan ◽  
Faouzi DIT Safadi ◽  
...  

In cardiac surgery, supplementation with recombinant factor VIIa is the treatment of choice for patients with factor VII deficiency, but overzealous administration can be associated with thromboembolic side-effects. A 53-year-old man with factor VII activity 15.2%, international normalized ratio 2.9, and acute thrombotic critical coronary anatomy, underwent coronary artery bypass surgery and a thoracotomy with decortication 5 months later. He was managed successfully without recombinant factor VIIa supplementation. This case demonstrates that current bedside and laboratory tests such as thromboelastography, prothrombin time or international normalized ratio, and factor VII activity may not predict replacement therapy in these patients.


1995 ◽  
Vol 74 (01) ◽  
pp. 313-321 ◽  
Author(s):  
Edward G D Tuddenham ◽  
Susan Pemberton ◽  
David N Cooper

1961 ◽  
Vol 05 (01) ◽  
pp. 087-092 ◽  
Author(s):  
F. J Cleton ◽  
E. A Loeliger

SummaryThe inheritance of congenital factor VII deficiency was investigated in 2 unrelated families. Out of 68 individuals, 4 (3 proven and 1 highly probable) were found to have severe factor VII deficiency (<C 0.1% factor VII), and 29 appeared to be heterozygotes (30—60% factor VII). The coagulation defect is due to an autosomal gene of intermediate expression and complete penetrance. The recessive character of the haemorrhagic diathesis due to the homozygous state for the abnormal gene is clearly demonstrated.


2002 ◽  
Vol 14 (4) ◽  
pp. 441-443 ◽  
Author(s):  
Andrew P. Chilton ◽  
Tariq Hussain ◽  
Elwyn Elias

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