Assessing Substance Use in Multiproblem Patients: Reliability and Validity of the Addiction Severity Index in a Mental Hospital Population

1997 ◽  
Vol 185 (3) ◽  
pp. 159-165 ◽  
Author(s):  
LAWRENCE APPLEBY ◽  
VIDA DYSON ◽  
EDWARD ALTMAN ◽  
DANIEL J. LUCHINS
2010 ◽  
Vol 40 (2) ◽  
pp. 495-515 ◽  
Author(s):  
Debra A. Murphy ◽  
Yih-Ing Hser ◽  
David Huang ◽  
Mary-Lynn Brecht ◽  
Diane M. Herbeck

1985 ◽  
Vol 173 (7) ◽  
pp. 412-423 ◽  
Author(s):  
A. THOMAS McLELLAN ◽  
LESTER LUBORSKY ◽  
JOHN CACCIOLA ◽  
JEFFREY GRIFFITH ◽  
FREDERICK EVANS ◽  
...  

2021 ◽  
Author(s):  
Jacinto Nuno Costa Azevedo ◽  
Cláudia Carvalho ◽  
Maria Paula Serrão ◽  
Rui Coelho ◽  
Margarida Figueiredo-Braga ◽  
...  

Abstract Background Impulsivity and substance use disorders (SUD) can be related to the same environmental factors. In this study, we intended to evaluate the dopaminergic function in imprisoned SUD offenders through the determination of s-COMT activity. Methods The study included 46 male individuals from a Portuguese penal institution. The participants were assessed through a battery of standardised instruments: Psychopathy Checklist-Revised (PCL-R), Barratt Impulsivity Scale Version 11 (BIS-11), and the European version of the Addiction Severity Index (EuropASI). s-COMT erythrocyte activity was evaluated. Results Overall, 73.9% (n=34) of the individuals had Antisocial Personality Disorder (ASPD) and 58.7% (n=27) presented SUDs. We evidenced, for the first time, that, in SUD individuals, s-COMT activity is correlated with the severity of drug dependence (EuropASI) (p<0.05), and with BIS-11 factors self-control (p<0.0001) and non-planning (p=0.002). Conclusions This study opens new perspectives regarding the pharmacological intervention on drug dependence through the interference on dopamine pathways.


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