Alloimmunization by hrʼ(c), Hemolytic Disease of Newborns, and Perinatal Management

Background: The complications of the SARS-CoV-2 infection and its COVID-19 disease on mothers and their offspring are less known. Objective: The aim of this review was to determine the transmission, severity, complications of SARS-CoV-2 infection during the pregnancy. This review showed the influence of COVID-19 disease on the neonatal neurogenesis. Owing to no specific vaccines or medicines that were reported for the treatment of COVID-19 disease, this review suggested some control strategies like treatments (medicinal plants, antiviral therapy, cellular therapy, and immunotherapy), nutrition uptake, prevention, and recommendations. Discussion: This overview showed in severely states that SARS-CoV-2 infection during the early stage of pregnancy might increase the risk of stress, panic, and anxiety. This disorder can disturb the maternal immune system, and thus causing a neurodevelopmental disturbance. This hypothesis may be depending on the severity and intensity of the SARS-CoV-2 infection during pregnancy. However, vertical transmission of SARS-CoV-2 from dams to their fetuses is absent until now. Conclusion: During this global pandemic disease, maintaining safety during pregnancy, vaginal delivery, and breastfeeding may play a vital role in a healthy life for the offspring. Thus, international and national corporations should be continuing for perinatal management, particularly during the next pandemic or disaster time.

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Hydrops fetalis with isolated massive ascites in a preterm neonate with rhesus disease

Wiener Medizinische Wochenschrift ◽

10.1007/s10354-021-00829-7 ◽

2021 ◽

Author(s):

Nasenien Nourkami-Tutdibi ◽

Martina Geipel ◽

Gabriele Meyberg-Solomayer ◽

Zoltan Takacs ◽

Sascha Meyer

Keyword(s):

Intensive Care ◽

Case Report ◽

Neonatal Intensive Care ◽

Preterm Neonate ◽

Fluid Collection ◽

Hemolytic Disease ◽

Massive Ascites ◽

Rhesus Incompatibility ◽

Trained Staff ◽

Clinical Stabilization

SummarySignificant progress in prenatal care has decreased the incidence of rhesus incompatibility, which may result in hemolytic disease of the fetus and newborn (HDFN). This case report describes an unusual presentation of HDFN in a preterm infant delivered by caesarean section with isolated massive abdominal fluid collection as the leading clinical sign in addition to severe anemia. The immediate drainage of ascites provided transient clinical stabilization with improved pulmonary function in the delivery suite. After admission to the neonatal intensive care unit (NICU), HDFN treatment was initiated. This case report shows the importance of adequately trained staff including neonatologists, pediatricians and NICU nurses in the delivery suite to provide neonatal intensive care for HDFN.

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