Oxyphilic (Hürthle Cell) Adenoma Arising in a Black Thyroid Gland

Abstract Background. Hürthle cell neoplasms could be benign (Hürthle cell adenoma) or malignant (Hürthle cell carcinoma). Hürthle cell carcinoma is a rare tumour, representing 5% of all differentiated thyroid carcinomas. The cytological evaluation of Hürthle cell neoplasms by fine needle aspiration biopsy (FNAB) is complicated because of the presence of Hürthle cells in both Hürthle cell adenoma and Hürthle cell carcinoma. Thus, the preoperative distinction between these two entities is very difficult and possible only with pathohistological findings of the removed tumour. Case report. A 57-year old female patient was admitted at our Department, for investigation of nodular thyroid gland. She was euthyroid and FNAB of the nodules in both thyroid lobes were consistent of Hürthle cell adenoma with cellular atypias. After thyroidectomy the histopathology revealed Hürthle cell adenoma with high cellular content and discrete cellular atypias in the left lobe and follicular thyroid adenoma without cellular atypias in the right lobe. One year after substitution therapy, a palpable tumour on the left side of the remnant tissue was found, significantly growing with time, presented as hot nodule on 99mTc-sestamibi scan and conclusive with Hürthle cell adenoma with marked cellularity on FNAB. Tumorectomy was performed and well-differentiated Hürthle cell carcinoma detected. The patient received ablative dose of 100 mCi 131I. No signs of metastatic disease are present up to date. Conclusions. The differences between Hürthle cell adenomas and Hürthle cell carcinomas could be clearly made only by histopathological evaluation. Patients with cytological diagnosis of Hürthle cell neoplasms should proceed to total thyroidectomy, especially if tumour size is > 1cm, FNAB findings comprise cellular atypias and/or multiple bilateral nodules are detected in the thyroid gland.

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Sarcoidosis of the Thyroid Gland and Concomitant Hürthle Cell Adenoma: Case Report

Journal of Medical Biochemistry ◽

10.2478/v10011-009-0010-2 ◽

2009 ◽

Vol 28 (2) ◽

pp. 129-131 ◽

Cited By ~ 1

Author(s):

Siniša Stojanoski ◽

Daniela Gjorceva ◽

Todor Gruev ◽

Svetlana Ristevska ◽

Nevena Ristevska ◽

...

Keyword(s):

Case Report ◽

Thyroid Gland ◽

Clinical History ◽

Underlying Disease ◽

Epithelioid Cell ◽

Pathological Examination ◽

Multisystem Disorder ◽

Cell Adenoma ◽

Diverse Range ◽

Hürthle Cell

Sarcoidosis of the Thyroid Gland and Concomitant Hürthle Cell Adenoma: Case Report Sarcoidosis is a multisystem disorder, characterized by the presence of noncaseating epithelioid-cell granulomas. The etiology remains unclear, although it is recognized as a disease of activated T lymphocytes. There is a diverse range of possible presentations with respiratory, gastrointestinal, reproductive, endocrine and other complications. The thyroid is an uncommon site of the disease with only 4% incidence according to some autopsy series. We present a case of a 55-year-old female patient with sarcoidosis of the thyroid gland and concomitant Hürthle cell adenoma. Upon performing a routine thyroid scintigraphy, a cold nodule has been observed. The diagnosis of the underlying disease was established by correlating the anamnesis data, patient's clinical history, fine needle aspiration biopsy and pathological examination of the thyroidectomy specimen. To our knowledge, the association has rarely been previously reported, indicating that thyroid involvement should be suspected in sarcoidosis patients who present with cold nodules.

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Thyroid Gland Hurthle Cell Adenoma

10.32388/79znt2 ◽

2020 ◽

Author(s):

Keyword(s):

Thyroid Gland ◽

Cell Adenoma ◽

Hürthle Cell

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Prevalence and Incidence of Cytoplasmic Yellow Bodies in Thyroid Neoplasms

Archives of Pathology & Laboratory Medicine ◽

10.5858/2003-127-715-paiocy ◽

2003 ◽

Vol 127 (6) ◽

pp. 715-717

Author(s):

Harold J. Rothenberg ◽

John R. Goellner ◽

J. Aidan Carney

Keyword(s):

Thyroid Gland ◽

Papillary Carcinoma ◽

Fine Needle Aspiration ◽

Mayo Clinic ◽

Fine Needle Aspiration Biopsy ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Cell Adenoma ◽

Fine Needle ◽

Hürthle Cell

Abstract Context.—Cytoplasmic yellow bodies are a common and frequent histologic finding in hyalinizing trabecular adenoma of the thyroid gland, a morphologically distinctive neoplasm, and are visible in fine-needle aspiration biopsy of the tumor. Objective.—To determine the prevalence and frequency of cytoplasmic yellow bodies in common thyroid tumors. Design.—Microscopic slides of random cases of papillary carcinoma (61 cases), follicular adenoma (27 cases), and Hürthle cell adenoma (12 cases) were searched for cytoplasmic yellow bodies. Setting and Patients.—Slides were from patients who had undergone surgery at Mayo Clinic, Rochester, Minn, and were obtained from the Mayo Clinic Tissue Registry. Main Outcome Measure.—Presence or absence of cytoplasmic yellow bodies. Results.—Cytoplasmic yellow bodies were found in papillary carcinoma (62%), follicular carcinoma (22%), and Hürthle cell adenoma (83%) but were very infrequent numerically in each tumor type. Conclusions.—Cytoplasmic yellow bodies may be present in papillary carcinoma and in follicular and Hürthle cell adenomas, but because they are uncommon in these tumors, they are unlikely to be found in fine-needle aspiration biopsy smears. Therefore, cytoplasmic yellow bodies are a useful cytomorphologic indicator of hyalinizing trabecular adenoma of the thyroid gland.

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Phyllodes Tumor Metastatic to Thyroid HürthleCell Adenoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/2002-126-1233-ptmtth ◽

2002 ◽

Vol 126 (10) ◽

pp. 1233-1236

Author(s):

Tamar Giorgadze ◽

Richard M. Ward ◽

Zubair W. Baloch ◽

Virginia A. LiVolsi

Keyword(s):

Tumor Metastasis ◽

Unusual Case ◽

Cellular Proliferation ◽

Phyllodes Tumor ◽

Thyroid Tumor ◽

Cell Adenoma ◽

Malignant Phyllodes Tumor ◽

Hürthle Cell ◽

Thyroid Mass ◽

Tumor To Tumor Metastasis

Abstract We present a case of a malignant phyllodes tumor metastasizing to a Hürthle cell adenoma of the thyroid. A 55-year-old woman underwent mastectomy for a malignant phyllodes tumor. Two years later, she presented with a left thyroid mass, which was a single, circumscribed, soft, deep red-brown nodular lesion with an eccentric area of firmer consistency. Histologically, the thyroid tumor was composed of 2 distinct types of cellular proliferation. Atypical spindle cells were infiltrating between the Hürthle cell cords and follicles in a fibrosarcomatous pattern. A battery of immunohistochemical stains was applied to both the thyroid and breast tumors for comparison. Based on the histologic and immunophenotypic features of the fibrosarcomatous components of both the breast and thyroid tumors, we rendered a diagnosis of cystosarcoma phyllodes metastatic to Hürthle cell adenoma. To the best of our knowledge, this unusual case is a first report of tumor-to-tumor metastasis of a sarcoma to a primary thyroid neoplasm.

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Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms

Frontiers in Endocrinology ◽

10.3389/fendo.2021.696386 ◽

2021 ◽

Vol 12 ◽

Author(s):

David G. McFadden ◽

Peter M. Sadow

Keyword(s):

Molecular Genetic ◽

Thyroid Neoplasms ◽

Invasive Disease ◽

Thyroid Tumor ◽

Molecular Testing ◽

Cell Adenoma ◽

Tumor Subtypes ◽

Hürthle Cell ◽

Hürthle Cell Tumors ◽

Widely Invasive

Hürthle cell lesions have been a diagnostic conundrum in pathology since they were first recognized over a century ago. Controversy as to the name of the cell, the origin of the cell, and even which cells in particular may be designated as such still challenge pathologists and confound those treating patients with a diagnosis of “Hürthle cell” anything within the diagnosis, especially if that anything is a sizable mass lesion. The diagnosis of Hürthle cell adenoma (HCA) or Hürthle cell carcinoma (HCC) has typically relied on a judgement call by pathologists as to the presence or absence of capsular and/or vascular invasion of the adjacent thyroid parenchyma, easy to note in widely invasive disease and a somewhat subjective diagnosis for minimally invasive or borderline invasive disease. Diagnostic specificity, which has incorporated a sharp increase in molecular genetic studies of thyroid tumor subtypes and the integration of molecular testing into preoperative management protocols, continues to be challenged by Hürthle cell neoplasia. Here, we provide the improving yet still murky state of what is known about Hürthle cell tumor genetics, clinical management, and based upon what we are learning about the genetics of other thyroid tumors, how to manage expectations, by pathologists, clinicians, and patients, for more actionable, precise classifications of Hürthle cell tumors of the thyroid.

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