Higher values of hepatic lipase activity in postmenopause: relationship with atherogenic intermediate density and low density lipoproteins

2001 ◽  
Vol 8 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Gabriela A. Berg ◽  
N??stor Siseles ◽  
Ana I. Gonz??lez ◽  
Oscar Contreras Ortiz ◽  
Antonio Tempone ◽  
...  
Keyword(s):  
Lipase Activity ◽  
Hepatic Lipase ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Hepatic Lipase Activity ◽  
Intermediate Density

scholarly journals Increased hepatic lipase activity and increased direct removal of very-low-density lipoprotein remnants in Watanabe heritable hyperlipidaemic (WHHL) rabbits treated with ethinyl oestradiol

1990 ◽  
Vol 272 (3) ◽  
pp. 647-651 ◽  
Author(s):  
P N M Demacker ◽  
M J T M Mol ◽  
A F H Stalenhoef
Keyword(s):  
Lipase Activity ◽  
Hepatic Lipase ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Hepatic Lipase Activity ◽  
Catabolic Rate ◽  
Apoprotein B ◽  
Secretion Rates ◽  
Ethinyl Oestradiol

We studied the effects of ethinyl oestradiol on the serum concentrations and metabolism of very-low- and low-density lipoproteins (VLDL and LDL) in Watanabe heritable hyperlipidaemic (WHHL) homozygous rabbits, an animal model for familial hypercholesterolaemia. The results were compared with those in untreated homozygotes as well as in heterozygotes treated or not with ethinyl oestradiol. The gain in body weight was similar in all groups. Treatment with ethinyl oestradiol resulted in the homozygotes in an approx. 80% decrease in the concentrations of lipids and apoprotein B in the d less than 1.019 lipoprotein fraction; those in the LDL fraction did not change. In the heterozygotes, basal serum lipids and apoprotein B levels in the d less than 1.019 fraction were low; ethinyl oestradiol treatment especially affected the LDL fraction (cholesterol -84%, apoprotein B -64%). Turnover experiments with 125I-labelled VLDL revealed that, on treatment with ethinyl oestradiol, the fractional catabolic rate in homozygous rabbits increased 2-fold. The secretion rates of lipids and protein in the d less than 1.019 fraction as estimated after injection of Triton WR-1339 was not decreased. In homozygotes and heterozygotes increases in post-heparin hepatic lipase activity of 62 and 80% respectively were observed, with no changes in lipoprotein lipase activity. We conclude that ethinyl oestradiol induces in homozygous WHHL rabbits a direct removal of VLDL and VLDL remnants from the plasma, apparently due to an increase in hepatic lipase activity.

scholarly journals Metabolic Consequences of Hypoxia from Birth and Dexamethasone Treatment in the Neonatal Rat: Comprehensive Hepatic Lipid and Fatty Acid Profiling

Endocrinology ◽  
2004 ◽  
Vol 145 (11) ◽  
pp. 5364-5372 ◽  
Author(s):  
Eric D. Bruder ◽  
Ping C. Lee ◽  
Hershel Raff
Keyword(s):  
Fatty Acid ◽  
Lipase Activity ◽  
Plasma Glucose ◽  
Plasma Lipids ◽  
Hepatic Lipase ◽  
Neonatal Rat ◽  
Significant Finding ◽  
Dexamethasone Treatment ◽  
Hepatic Lipase Activity ◽  
Hepatic Lipid

Abstract Neonatal hypoxia is a common condition resulting from pulmonary and/or cardiac dysfunction. Dexamethasone therapy is a common treatment for many causes of neonatal distress, including hypoxia. The present study examined the effects of dexamethasone treatment on both normoxic and hypoxic neonatal rats. We performed comprehensive hepatic fatty acid/lipid profiling and evaluated changes in pertinent plasma hormones and lipids and a functional hepatic correlate, i.e. hepatic lipase activity. Rats were exposed to hypoxia from birth to 7 d of age. A 4-d tapering dose regimen of dexamethasone was administered on: postnatal day (PD)3 (0.5 mg/kg), PD4 (0.25 mg/kg), PD5 (0.125 mg/kg), and PD6 (0.05 mg/kg). The most significant finding was that dexamethasone attenuated nearly all hypoxia-induced changes in hepatic lipid profiles. Hypoxia increased the concentration of hepatic triacylglyceride and free fatty acids and, more specifically, increased a number of fatty acid metabolites within these lipid classes. Administration of dexamethasone blocked these increases. Hypoxia alone increased the plasma concentration of cholesterol and triacylglyceride, had no effect on plasma glucose, and only tended to increase plasma insulin. Dexamethasone administration to hypoxic pups resulted in an additional increase in plasma lipid concentrations, an increase in insulin, and a decrease in plasma glucose. Hypoxia and dexamethasone treatment each decreased total hepatic lipase activity. Normoxic pups treated with dexamethasone displayed increased plasma lipids and insulin. The effects of dexamethasone on hepatic function in the hypoxic neonate are dramatic and have significant implications in the assessment and treatment of metabolic dysfunction in the newborn.

scholarly journals Interactions of dietary fat intake and the hepatic lipase –480C→T polymorphism in determining hepatic lipase activity: the Hoorn Study

2005 ◽  
Vol 81 (4) ◽  
pp. 911-915 ◽  
Author(s):  
Griët Bos ◽  
Jacqueline M Dekker ◽  
Edith JM Feskens ◽  
Marga C Ocke ◽  
Giel Nijpels ◽  
...  
Keyword(s):  
Lipase Activity ◽  
Dietary Fat ◽  
Hepatic Lipase ◽  
Fat Intake ◽  
Hepatic Lipase Activity ◽  
Dietary Fat Intake

Variability in Postheparin Hepatic Lipase Activity Is Associated with Plasma Adiponectin Levels in African Americans

2007 ◽  
Vol 55 (4) ◽  
pp. 187-194 ◽  
Author(s):  
Jacob J. Clarenbach ◽  
Gloria Lena Vega ◽  
Beverley Adams-Huet ◽  
Robert V. Considine ◽  
Madia Ricks ◽  
...  
Keyword(s):  
African Americans ◽  
Lipase Activity ◽  
Hepatic Lipase ◽  
Plasma Adiponectin ◽  
Hepatic Lipase Activity

The disappearance rate of human versus rat intermediate density lipoproteins from rat liver perfusion

1991 ◽  
Vol 69 (8) ◽  
pp. 537-543 ◽  
Author(s):  
Robert Dupras ◽  
Louise Brissette ◽  
Paul D. Roach ◽  
Sylvain Begin ◽  
André Tremblay ◽  
...  
Keyword(s):  
Liver Perfusion ◽  
Density Lipoprotein ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Disappearance Rate ◽  
Very Low Density Lipoproteins ◽  
Rat Liver Perfusion ◽  
Heparin Plasma ◽  
Intermediate Density

The aim of this work was to compare the disappearance rate of human and rat intermediate density lipoproteins (IDL) using the rat liver perfusion system. Human and rat IDL were produced in vitro by incubating human or rat very low density lipoproteins (VLDL) with either rat post-heparin plasma (method I) or a resolubilized isopropanol precipitate of rat post-heparin plasma (method II). With both methods, the degree of triacylglycerol lipolysis was approximately 55%. The different preparations of IDL were labelled with 125I and added to perfusates of rat livers. The disappearance rates of 125I-labelled IDL were monitored by measuring the radioactivity associated with apolipoprotein (apo) B in the perfusate during a 15-min period. Both human and rat IDL prepared with method I had an increased apoE to apoC ratio as compared with their native counterparts. Furthermore, human IDL had a significantly higher apoE to apoC ratio than rat IDL. However, when IDL were produced in the absence of exchangeable apolipoproteins (method II), no change in the apoE to apoC ratios was observed for the transformation of VLDL to IDL and the ratios were similar for human and rat IDL. Despite these differences, human IDL were always removed at a lower rate than rat IDL. The only striking difference between the two types of IDL made by method II was that the apoB100 to apoB48 ratio was considerably higher in human than in rat IDL. These results suggest that the apoB100 to apoB48 ratio is likely to be responsible for the observed differences in liver uptake between rat and human IDL.Key words: very low density lipoproteins, intermediate density lipoproteins, low density lipoproteins, hepatic lipoprotein receptors, intermediate density lipoprotein uptake, in vitro lipolysis, very low density lipoprotein remnants, apolipoproteins.

Effects of steroid hormones on rat hepatic lipase activity

1994 ◽  
Vol 109 (1-2) ◽  
pp. 61
Author(s):  
A. Mitchell ◽  
P.L. Griffiths ◽  
N.H. Fidge
Keyword(s):  
Steroid Hormones ◽  
Lipase Activity ◽  
Hepatic Lipase ◽  
Hepatic Lipase Activity

scholarly journals Vanadate-Stimulated Release of Hepatic Lipase Activity from Liver.

1991 ◽  
Vol 39 (12) ◽  
pp. 3287-3289 ◽  
Author(s):  
Tetsuo MORITA ◽  
Fuminori MIKAMI ◽  
Asako KANAGAWA ◽  
Misaki SERA ◽  
Hiroshi UEKI
Keyword(s):  
Lipase Activity ◽  
Hepatic Lipase ◽  
Hepatic Lipase Activity
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