Prediction of response based on viral decline during PEG-interferon alpha-2b therapy in HBeAg-positive chronic hepatitis B

2006 ◽  
Vol 18 (1) ◽  
pp. A57
Author(s):  
MJ ter Borg ◽  
BE Hansen ◽  
RA de Man ◽  
SW Schalm ◽  
HLA Janssen
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Prediction Of Response ◽  
Interferon Alpha 2B ◽  
Positive Chronic Hepatitis

scholarly journals Patterns of viral decline during PEG-interferon alpha-2b therapy in HBeAg-positive chronic hepatitis B: Relation to treatment response

Hepatology ◽  
2006 ◽  
Vol 44 (3) ◽  
pp. 721-727 ◽  
Author(s):  
Martijn J. ter Borg ◽  
Monika van Zonneveld ◽  
Stefan Zeuzem ◽  
Hakan Senturk ◽  
Ulus S. Akarca ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Treatment Response ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Interferon Alpha 2B ◽  
Positive Chronic Hepatitis

Treatment with Peg-Interferon alpha-2b for HBeAg-Positive Chronic Hepatitis B: HBsAg Loss Is Associated with HBV Genotype

2006 ◽  
Vol 101 (2) ◽  
pp. 297-303 ◽  
Author(s):  
Hajo J. Flink ◽  
Monika van Zonneveld ◽  
Bettina E. Hansen ◽  
Robert A. de Man ◽  
Solko W. Schalm ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Hbv Genotype ◽  
Interferon Alpha 2B ◽  
Hbsag Loss ◽  
Positive Chronic Hepatitis

Low pretreatment serum HBsAg level and viral mutations as predictors of response to PEG-interferon alpha-2b therapy in chronic hepatitis B

2009 ◽  
Vol 46 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Pisit Tangkijvanich ◽  
Piyawat Komolmit ◽  
Varocha Mahachai ◽  
Pattaratida Sa-nguanmoo ◽  
Apiradee Theamboonlers ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Hbsag Level ◽  
Interferon Alpha 2B ◽  
Serum Hbsag ◽  
Predictors Of Response ◽  
Serum Hbsag Level ◽  
Pretreatment Serum

FRI-163-Reduced liver-related complications after 13 years of follow-up of interferon-alpha treatment for HBeAg-positive chronic hepatitis B: The ELITE-B study

2019 ◽  
Vol 70 (1) ◽  
pp. e460
Author(s):  
Hannah S.J. Choi ◽  
Margo J.H. van Campenhout ◽  
Cedric de Jong ◽  
Hanneke van Vuuren ◽  
Milan Sonneveld ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Positive Chronic Hepatitis ◽  
Interferon Alpha Treatment

Effects of recombinant leukocyte interferon on ribonuclease activities in serum in chronic hepatitis B

1990 ◽  
Vol 36 (6) ◽  
pp. 913-916 ◽  
Author(s):  
H Tsuji ◽  
K Murai ◽  
K Akagi ◽  
M Fujishima
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Close Correlation ◽  
Rnase Activity ◽  
Human Interferon ◽  
Oligoadenylate Synthetase ◽  
Interferon Alpha 2B ◽  
Positive Chronic Hepatitis ◽  
Alkaline Ribonuclease

Abstract Alkaline ribonuclease (RNase; EC 3.1.27.5) activities and 2',5'-oligoadenylate synthetase (2-5 AS; no EC no. assigned) activities in serum were measured in nine patients with hepatitis B e antigen-positive chronic hepatitis B before, during, and after treatment with recombinant human interferon alpha-2b for four weeks at daily doses ranging from 3 to 10 mega-units. Alkaline RNase activities in serum significantly increased from 65.8 +/- 9.5 units/L (mean +/- SD) to 84.3 +/- 11.9 units/L after the first week of therapy (P less than 0.001). (One unit of RNase activity is defined as that increasing the absorbance at 260 nm by 1.0 in 1 min). This increase persisted during and until two weeks after the end of the therapy, at which time the mean RNase activity in serum was still significantly increased (70.8 +/- 9.4 units/L, P less than 0.01). Before therapy, phosphocellulose chromatography of RNase showed five active peaks of enzyme activity, which were similar to that observed even when RNase activity increased immediately after therapy. There was a close correlation between RNase activities and the logarithm of 2-5 AS activities, measured simultaneously in each patient. We conclude that recombinant alpha-interferon therapy increases RNase activities in serum, associated with the increased 2-5 AS activities.

Sign in / Sign up

Export Citation Format

Share Document