Immunologic Reconstitution After 1 Year of Highly Active Antiretroviral Therapy, With or Without Protease Inhibitors

2002 ◽  
Vol 29 (5) ◽  
pp. 429-434 ◽  
Author(s):  
Montserrat Plana ◽  
Catalina Martínez ◽  
Felipe García ◽  
María J. Maleno ◽  
Juan J. Barceló ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Protease Inhibitors ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
Immunologic Reconstitution

Immunologic Reconstitution After 1 Year of Highly Active Antiretroviral Therapy, With or Without Protease Inhibitors

2002 ◽  
Vol 29 (5) ◽  
pp. 429-434 ◽  
Author(s):  
Montserrat Plana ◽  
Catalina Martínez ◽  
Felipe García ◽  
María J. Maleno ◽  
Juan J. Barceló ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Protease Inhibitors ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
Immunologic Reconstitution

Virologic Outcome and Predictors of Virologic Failure of Highly Active Antiretroviral Therapy Containing Protease Inhibitors

2001 ◽  
Vol 15 (4) ◽  
pp. 193-199 ◽  
Author(s):  
Hernando Knobel ◽  
Ana Guelar ◽  
Alexia Carmona ◽  
Mercedes Espona ◽  
Alicia González ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Protease Inhibitors ◽  
Highly Active Antiretroviral Therapy ◽  
Virologic Failure ◽  
Highly Active

Response of Severe HIV-Associated Thrombocytopenia to Highly Active Antiretroviral Therapy Including Protease Inhibitors

2001 ◽  
Vol 42 (4) ◽  
pp. 251-256 ◽  
Author(s):  
S. Carbonara ◽  
G. Fiorentino ◽  
G. Serio ◽  
P. Maggi ◽  
G. Ingravallo ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Protease Inhibitors ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active

scholarly journals HIV protease inhibitors inhibit FACE1/ZMPSTE24: a mechanism for acquired lipodystrophy in patients on highly active antiretroviral therapy?

2010 ◽  
Vol 38 (1) ◽  
pp. 292-296 ◽  
Author(s):  
Chris N. Goulbourne ◽  
David J. Vaux
Keyword(s):  
Antiretroviral Therapy ◽  
Protease Inhibitors ◽  
Highly Active Antiretroviral Therapy ◽  
Molecular Mechanisms ◽  
Regulatory Element ◽  
Hiv Protease ◽  
Sterol Synthesis ◽  
Hiv Protease Inhibitors ◽  
Prelamin A ◽  
Highly Active

HIV-PIs (HIV protease inhibitors) have proved to be of great benefit for the millions of people suffering from AIDS. However, one of the side effects of this component of combined highly active antiretroviral therapy is lipodystrophy, which affects a large number of the patients taking this class of drug. It has been shown that many of these protease inhibitors inhibit the ZMPSTE24 enzyme responsible for removing the farnesylated tail of prelamin A, which is a nuclear lamina component that has been implicated in some of the nuclear laminopathies. Build up of this protein somehow leads to acquired lipodystrophy, possibly through its interaction with a transcription factor called SREBP-1 (sterol-regulatory-element-binding protein-1). The downstream effect of this is altered fatty acid metabolism and sterol synthesis, which may cause lipodystrophy in patients. The build-up of this protein also appears to have morphological consequences on the nucleus and we reveal, by dual-axis electron tomography, a complex nucleoplasmic reticulum that forms after HIV-PI treatment as a result of acute farnesylated prelamin A accumulation. A greater understanding of the molecular mechanisms leading to lipodystrophy will hopefully facilitate the design of improved HIV-PIs that do not cause this debilitating side effect.

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