LEVODOPA MAY IMPROVE VISION LOSS IN RECENT-ONSET, NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY

2000 ◽  
Vol 1 (4) ◽  
pp. 232-233
Author(s):  
Neil R. Miller
Keyword(s):  
Optic Neuropathy ◽  
Vision Loss ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Recent Onset

scholarly journals Protective effects of quercetin in a rodent model of anterior ischemic optic neuropathy (rAION)

2019 ◽  
Author(s):  
Ya-nan Lyu ◽  
Jing-yu Min ◽  
Yuanyuan Gong ◽  
qing Gu ◽  
fang Wei
Keyword(s):  
Intravitreal Injection ◽  
Optic Neuropathy ◽  
Vision Loss ◽  
Ganglion Cells ◽  
Rodent Model ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Protective Effects ◽  
High Power Field ◽  
Optic Nerves

Abstract Background: Anterior ischemic optic neuropathy (AION) is the leading cause of sudden optic nerve-related (ON-related) vision loss in elderly people. However, no considerable treatments are available for the neuroprotection of NAION. The purpose of this study was to detect the effects of intravitreal injection of quercetin (Qcn) in a rodent model of anterior ischemic optic neuropathy (rAION). Methods: The rAION model was established using verteporfin and laser in a photodynamic procedure on the optic discs (ON) of rats. The rats received intravitreal injection of Qcn 2 days before the injury and once/week for 4 weeks after the infarct on optic neuropathy. Flash-visual evoked potential (VEP) were recorded to assess the visual function. TUNEL and retrograde Fluorogold labeling assessed the apoptosis and density of retinal ganglion cells (RGCs). ED-1 and Iba-1 staining of the optic nerves displayed the inflammatory response. Results: At 14 days post-infarct, Qcn treatment significantly reduced the number of apoptotic RGCs, as well as, ED1/Iba-1-positive cells/high power field(HPF) in the ON (p<0.01) as compared to the rAION group. At week 4 after rAION, 28.4% VEP amplitudes were estimated in the treated eyes of the fellow eyes in the rAION group and 64.7% in the rAION+Qcn group (p<0.01). In addition, Qcn saved the RGCs in the central retinas as compared to those of the rAION group (1967.5±162.1 and 2868±325.3 mm2, respectively (p<0.01), and the corresponding densities were 1654.8±104.8 and 2208±272.9 mm2 in the mid-peripheral retinas, respectively (p<0.01). Conclusion: The intravitreal injection of Qcn could protect the RGCs from injury in the rAION animal model, as demonstrated anatomically by RGC density and functionally by F-VEP. Moreover, Qcn might exert an anti-apoptosis role in the survival of RGCs and anti-inflammatory in the optic nerves.

Intravitreal Injection of a Rho-Kinase Inhibitor (Fasudil) for Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy

2015 ◽  
Vol 56 (6) ◽  
pp. 749-753 ◽  
Author(s):  
Nasrin Sanjari ◽  
Mohammad Pakravan ◽  
Ramin Nourinia ◽  
Hamed Esfandiari ◽  
Ali Hafezi-Moghadam ◽  
...  
Keyword(s):  
Intravitreal Injection ◽  
Optic Neuropathy ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Recent Onset ◽  
Rho Kinase Inhibitor

scholarly journals Clinical and ultrasonographic features in anterior ischemic optic neuropathy

2018 ◽  
Vol 75 (8) ◽  
pp. 773-779
Author(s):  
Dragos Jianu ◽  
Nina Jianu ◽  
Mihnea Munteanu ◽  
Ligia Petrica
Keyword(s):  
Optic Neuropathy ◽  
Vision Loss ◽  
Clinical Symptoms ◽  
Color Doppler ◽  
Resistance Index ◽  
Doppler Imaging ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Dark Halo ◽  
Ciliary Arteries

Background/Aim. Anterior ischemic optic neuropathy (AION) represent a segmental infarction of the optic nerve head which is supplied by the posterior ciliary arteries. There are two types of AION: non-arteritic (NAAION and arteritic (A-AION), due to giant cell arteritis (GCA). The aim of this study was to investigate the clinical features and ultrasound characteristics of the orbital vessels and superficial temporal and carotid arteries, in patients with unilateral acute AION in order to help differentiate newly diagnosed NA-AION from AAION. Methods. In this prospective comparative, observational study, 62 consecutive patients with clinical suspicion of unilateral acute AION were examined at admission and in the first two months of evolution, following a protocol including color Doppler imaging (CDI) of the orbital vessels. Results. We found 12 patients with A-AION, all of them with biopsy-confirmed disease, and 50 patients with NA-AION. A-AION patients presented a combination of a history of amaurosis fugax before acute, painless, and severe vision loss in the affected eye, and a diffuse pale optic disc edema. In these patients, CDI of the orbital vessels indicated high resistance index (RI), with severe diminished blood flow velocities in all orbital vessels, in both orbits. In the NAAION patients, none of these clinical symptoms were found and blood velocities and RI in posterior ciliary arteries were preserved. Typical sonographic feature in temporal arteritis as part of GCA was the ?dark halo? sign. Conclusions. The ultrasound investigations enable prompt differentiation between NA-AION and A-AION.

scholarly journals Optic Disc Swelling and Vision Loss in a Patient with Cystic Fibrosis and Diabetes

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Ioulia Iosfina ◽  
Jean Y. Chuo ◽  
Derek V. Godinho ◽  
Pearce G. Wilcox ◽  
Stuart H. Kreisman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Life Expectancy ◽  
Optic Disc ◽  
Optic Neuropathy ◽  
Vision Loss ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Complications Of Diabetes ◽  
Optic Disc Swelling

Advances in cystic fibrosis management have significantly improved life expectancy in these patients. However, we are now faced with a growing number of long-term extrapulmonary consequences of this disease, including ophthalmic complications of diabetes in cystic fibrosis patients. We present a unique report that documents a case of diabetic papillopathy progressing to nonarteritic anterior ischemic optic neuropathy resulting in vision loss in a patient with CF and diabetes. It highlights the potentially devastating consequences of longstanding diabetes in CF patients.

scholarly journals Anterior ischemic optic neuropathy as a rare manifestation of COVID-19: a case report

2022 ◽  
Author(s):  
Khodayar Golabchi ◽  
Alireza Rezaee ◽  
Davood Aghadoost ◽  
Maryam Hashemipour
Keyword(s):  
Case Report ◽  
Optic Neuropathy ◽  
Vision Loss ◽  
Past History ◽  
Sudden Onset ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Ocular Manifestations ◽  
Rare Manifestation ◽  
The Right

Aim: A variety of manifestations in different organs could be associated with severe COVID-19; for example, ocular manifestations. Case report: A 52-year-old male complaining of sudden onset unilateral painless vision loss in the right eye for 1 month (started just 1 week after COVID-19 remission) came to the ophthalmology clinic. On further evaluations, he was diagnosed with anterior ischemic optic neuropathy (AION). Considering his past history and the result of evaluations, the hypothesis of association between AION and COVID-19 was proposed. Results & discussion: Ocular and neurologic manifestations of COVID-19 are more likely to happen in patients with more severe conditions. Complications occur secondary to two basic mechanisms including severe inflammatory response and hypercoagulable state. Conclusion: Our findings indicated that non-arteritic AION is another manifestation of microangiopathic/thrombotic events which may occur in the course of COVID-19.

scholarly journals Nonarteritic Anterior Ischemic Optic Neuropathy following Herpes Zoster Ophthalmicus and Steroid-Related Intraocular Pressure Spike

2021 ◽  
pp. 11-15
Author(s):  
Po Hsiang Yuan ◽  
Jonathan A. Micieli
Keyword(s):  
Intraocular Pressure ◽  
Herpes Zoster ◽  
Optic Neuropathy ◽  
Temporal Relationship ◽  
Vision Loss ◽  
Anterior Ischemic Optic Neuropathy ◽  
Topical Steroids ◽  
Ischemic Optic Neuropathy ◽  
Herpes Zoster Ophthalmicus ◽  
Varicella Zoster

A 61-year-old woman presented with sudden vision loss from a left anterior optic neuropathy in the context of severely elevated intraocular pressure after starting topical steroids for anterior uveitis related to herpes zoster ophthalmicus (HZO). The strong temporal relationship between the vision loss and elevated IOP suggested the vision loss was related to nonarteritic anterior ischemic optic neuropathy (NAION). Anterior chamber paracentesis did not detect varicella zoster virus (VZV) and magnetic resonance imaging of the orbits was normal. Her vision remained stable and the optic disc edema resolved within 3 months. The occurrence of NAION following an acute elevation of intraocular pressure (IOP) is well-documented in the context of surgical procedures, glaucoma, uveitis and trauma. This case indicates that not every optic neuropathy in close temporal relationship with HZO is directly attributable to the virus. NAION may also occur after steroid-related IOP spikes and ophthalmologists should ensure that patients on topical steroids are closely monitored for ocular complications.

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