Prone position delays the progression of ventilator-induced lung injury in rats: Does lung strain distribution play a role?*

2005 ◽  
Vol 33 (2) ◽  
pp. 361-367 ◽  
Author(s):  
Franco Valenza ◽  
Massimiliano Guglielmi ◽  
Micol Maffioletti ◽  
Cecilia Tedesco ◽  
Patrizia Maccagni ◽  
...  
Keyword(s):  
Lung Injury ◽  
Prone Position ◽  
Strain Distribution ◽  
Ventilator Induced Lung Injury ◽  
Lung Strain

Effects of The Prone Position on Regional Neutrophilic Lung Inflammation According To 18F-FDG PET In An Experimental Ventilator-Induced Lung Injury Model

Shock ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Susumu Nakahashi ◽  
Hiroshi Imai ◽  
Nobutake Shimojo ◽  
Yasuhiro Magata ◽  
Takahiro Einama ◽  
...  
Keyword(s):  
Lung Injury ◽  
Prone Position ◽  
Fdg Pet ◽  
Lung Inflammation ◽  
Ventilator Induced Lung Injury ◽  
Injury Model ◽  
Lung Injury Model ◽  
18F Fdg

scholarly journals Regional tidal lung strain in mechanically ventilated normal lungs

2016 ◽  
Vol 121 (6) ◽  
pp. 1335-1347 ◽  
Author(s):  
Luis Felipe Paula ◽  
Tyler J. Wellman ◽  
Tilo Winkler ◽  
Peter M. Spieth ◽  
Andreas Güldner ◽  
...  
Keyword(s):  
Lung Injury ◽  
Tidal Volume ◽  
Lung Volume ◽  
Mechanically Ventilated ◽  
Reference Volume ◽  
Ventilator Induced Lung Injury ◽  
Vertical Heterogeneity ◽  
Dorsal Axis ◽  
Lung Strain ◽  
Normal Lungs

Parenchymal strain is a key determinant of lung injury produced by mechanical ventilation. However, imaging estimates of volumetric tidal strain (ε = regional tidal volume/reference volume) present substantial conceptual differences in reference volume computation and consideration of tidally recruited lung. We compared current and new methods to estimate tidal volumetric strains with computed tomography, and quantified the effect of tidal volume (VT) and positive end-expiratory pressure (PEEP) on strain estimates. Eight supine pigs were ventilated with VT = 6 and 12 ml/kg and PEEP = 0, 6, and 12 cmH2O. End-expiratory and end-inspiratory scans were analyzed in eight regions of interest along the ventral-dorsal axis. Regional reference volumes were computed at end-expiration (with/without correction of regional VT for intratidal recruitment) and at resting lung volume (PEEP = 0) corrected for intratidal and PEEP-derived recruitment. All strain estimates demonstrated vertical heterogeneity with the largest tidal strains in middependent regions ( P < 0.01). Maximal strains for distinct estimates occurred at different lung regions and were differently affected by VT-PEEP conditions. Values consistent with lung injury and inflammation were reached regionally, even when global measurements were below critical levels. Strains increased with VT and were larger in middependent than in nondependent lung regions. PEEP reduced tidal-strain estimates referenced to end-expiratory lung volumes, although it did not affect strains referenced to resting lung volume. These estimates of tidal strains in normal lungs point to middependent lung regions as those at risk for ventilator-induced lung injury. The different conditions and topography at which maximal strain estimates occur allow for testing the importance of each estimate for lung injury.

Ventilator-induced lung injury

2003 ◽  
Vol 9 (3) ◽  
pp. 343-362 ◽  
Author(s):  
A ADAMS ◽  
D SIMONSON ◽  
D DRIES
Keyword(s):  
Lung Injury ◽  
Ventilator Induced Lung Injury

The circadian clock modulates susceptibility of mice to ventilator-induced lung injury

Pneumologie ◽  
2018 ◽  
Vol 72 (S 01) ◽  
pp. S10-S11
Author(s):  
M Felten ◽  
LG Teixeira Alves ◽  
C Chaput ◽  
E Letsiou ◽  
N Suttorp ◽  
...  
Keyword(s):  
Lung Injury ◽  
Circadian Clock ◽  
Ventilator Induced Lung Injury
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