LACK OF ADDITIONAL PROGNOSTIC BENEFIT BEYOND BLOOD PRESSURE LOWERING EFFECTS IN COMBINATION OF RENIN-ANGIOTENSIN SYSTEM INHIBITOR AND CALCIUM CHANNEL BLOCKER: 2B.04

2010 ◽  
Vol 28 ◽  
pp. e18
Author(s):  
M Fujita ◽  
S Mitani ◽  
S Miyamoto ◽  
A Ikai ◽  
T Yamazaki ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Renin Angiotensin System ◽  
Blood Pressure Lowering ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Pressure Lowering

Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema

2011 ◽  
Vol 124 (2) ◽  
pp. 128-135 ◽  
Author(s):  
Harikrishna Makani ◽  
Sripal Bangalore ◽  
Jorge Romero ◽  
Omar Wever-Pinzon ◽  
Franz H. Messerli
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Peripheral Edema ◽  
Renin Angiotensin

Sodium Restriction and Inhibition of the Renin—Angiotensin System in Renovascular Hypertension in the Rat

1977 ◽  
Vol 52 (4) ◽  
pp. 371-375
Author(s):  
J. D. Swales ◽  
H. Thurston
Keyword(s):  
Blood Pressure ◽  
Enzyme Inhibitor ◽  
Renin Angiotensin System ◽  
Small Contribution ◽  
Bilateral Nephrectomy ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Pressure Lowering

1. In the early phase of hypertension produced by renal artery constriction with the opposite kidney intact, infusion of the angiotensin antagonist Sar1-Ala8-angiotensin II or bilateral nephrectomy lowered blood pressure. However, the extent of the fall was variable and some animals remained hypertensive after each procedure. 2. To assess whether sodium retention was the additional factor which maintained blood pressure when the renin—angiotensin system was suppressed, rats were maintained on a low-salt diet before and during the development of hypertension. The blood pressure-lowering effect of bilateral nephrectomy or antagonist infusion was not enhanced. 3. Infusion of antagonist or converting-enzyme inhibitor 6 h after bilateral nephrectomy had only a minor blood pressure-lowering action, indicating that, at this late stage after nephrectomy, the renin—angiotensin system makes only a very small contribution to blood pressure maintenance.

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