scholarly journals PS1488 ATYPICAL HAEMOLYTIC URAEMIC SYNDROME IN THE ECULIZUMAB ERA: PRESENTATION, RESPONSE TO TREATMENT AND EVALUATION OF AN ECULIZUMAB WITHDRAWAL STRATEGY

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 685-686
Author(s):  
L. Neave ◽  
D. Gale ◽  
S. Cheesman ◽  
S. Raakhee ◽  
M. Scully
Keyword(s):  
Haemolytic Uraemic Syndrome ◽  
Response To Treatment ◽  
Atypical Haemolytic Uraemic Syndrome

Successful treatment with eculizumab in a patient with pregnancy-associated atypical hemolytic uremic syndrome

2021 ◽  
pp. 1753495X2110199
Author(s):  
Mehmet Nuri Duran ◽  
Fatma Beyazit ◽  
Mesut Erbaş ◽  
Onur Özkavak ◽  
Celal Acar ◽  
...  
Keyword(s):  
Haemolytic Uraemic Syndrome ◽  
Gestational Hypertension ◽  
Severe Renal Impairment ◽  
Post Partum ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Kidney Injury ◽  
Rapid Improvement ◽  
Plasma Therapy ◽  
Elevated Liver Enzymes ◽  
Atypical Haemolytic Uraemic Syndrome

Pregnancy‐associated atypical haemolytic uraemic syndrome is a rare and potentially lethal complement-mediated disorder. It can mimic preeclampsia, gestational hypertension, thrombotic thrombocytopenic purpura and hemolysis, elevated liver enzymes and low platelets syndrome. Thus, it can be hard to distinguish pregnancy‐associated atypical haemolytic uraemic syndrome from other causes in peri/post-partum women presenting with features of microangiopathic haemolytic anemia, thrombocytopenia and acute kidney injury. We present a case of a 35-year-old woman in her third pregnancy at 32 weeks’ gestation who underwent caesarean section due to fetal distress. She developed severe renal impairment, thrombocytopenia and neurologic symptoms within 24 hours after delivery. A diagnosis of pregnancy‐associated atypical haemolytic uraemic syndrome was provided, and treatment with plasma therapy followed by eculizumab was initiated. A rapid improvement of both clinical and laboratory parameters was observed. This case demonstrates the significance of early initiation of anti-complement therapy to prevent irreversible renal damage and possible death in women with pregnancy‐associated atypical haemolytic uraemic syndrome.

scholarly journals Correction to: Ravulizumab: A Review in Atypical Haemolytic Uraemic Syndrome

Drugs ◽  
2021 ◽  
Author(s):  
Yahiya Y. Syed
Keyword(s):  
Open Access ◽  
Haemolytic Uraemic Syndrome ◽  
Atypical Haemolytic Uraemic Syndrome

The article Ravulizumab: A Review in Atypical Haemolytic Uraemic Syndrome, written by Yahiya Y. Syed, was originally published electronically in SpringerLink on 18 March 2021 without open access.

Patient stratification and therapy in atypical haemolytic uraemic syndrome (aHUS)

Immunobiology ◽  
2016 ◽  
Vol 221 (6) ◽  
pp. 715-718 ◽  
Author(s):  
Edwin Wong ◽  
Rachel Challis ◽  
Neil Sheerin ◽  
Sally Johnson ◽  
David Kavanagh ◽  
...  
Keyword(s):  
Haemolytic Uraemic Syndrome ◽  
Patient Stratification ◽  
Atypical Haemolytic Uraemic Syndrome

scholarly journals Eculizumab in secondary atypical haemolytic uraemic syndrome

2017 ◽  
Vol 32 (3) ◽  
pp. 466-474 ◽  
Author(s):  
Teresa Cavero ◽  
Cristina Rabasco ◽  
Antía López ◽  
Elena Román ◽  
Ana Ávila ◽  
...  
Keyword(s):  
Haemolytic Uraemic Syndrome ◽  
Atypical Haemolytic Uraemic Syndrome
Sign in / Sign up

Export Citation Format

Share Document