MAGNETIC RESONANCE SPECTROSCOPY AS AN ALTERNATIVE TOOL FOR LIVER BIOPSY IN LIVING DONOR LIVER TRANSPLANTATION

Abstract Background Recently, the living donor liver transplantation (LDLT) surgery is employed as the treatment of choice for end-stage chronic liver disease and hepatocellular carcinoma. The role of liver biopsy in donor’s selection protocol for adult living liver donors (LLDs) candidates is a point of controversy. Hepatic magnetic resonance elastography (MRE) is a promising technique particularly in grading of liver fibrosis that can be used for pre-transplantation evaluation of the LLDs candidates. The aim of the current study was to evaluate the diagnostic performance of hepatic MRE as a pre-transplantation imaging tool for LLDs candidates, prior to LDLT surgery. Results Thirty-seven eligible healthy LLDs candidates (28 males and 9 females; their ages ranged from 24 to 45 years) were the subject of the current study. A cut-off value ≥ 2.24 kilo Pascal (kPa) was assumed for discrimination between normal and abnormal hepatic tissues with high accuracy (99.24%). Also, a cut-off value ≥ 2.38 kPa for grading steatosis gave 98.44% accuracy, while a cut-off value ≥ 2.57 kPa for discriminating fibrosis stages yielded 98.80% accuracy. Conclusion MRE can be considered as a reliable non-invasive pre-transplant screening technique that has the potential to alternate the invasive liver biopsy technique in selection and validation of LLDs candidates for LDLT surgery.

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The diminishing role of liver biopsy in living donor liver transplantation

Liver Transplantation ◽

10.1002/lt.25038 ◽

2018 ◽

Vol 24 (4) ◽

pp. 457-458 ◽

Cited By ~ 1

Author(s):

James F. Trotter

Keyword(s):

Liver Transplantation ◽

Liver Biopsy ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Donor Liver ◽

Donor Liver Transplantation

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Non-Invasive Assessment of Graft Fibrosis After Living Donor Liver Transplantation: Is There Still a Role for Liver Biopsy?

Transplantation Proceedings ◽

10.1016/j.transproceed.2019.01.197 ◽

2019 ◽

Vol 51 (7) ◽

pp. 2451-2456 ◽

Cited By ~ 1

Author(s):

M. El-Meteini ◽

M. Sakr ◽

A. Eldorry ◽

Z. Mohran ◽

N.A. Abdelkader ◽

...

Keyword(s):

Liver Transplantation ◽

Liver Biopsy ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Donor Liver ◽

Donor Liver Transplantation ◽

Non Invasive

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Magnetic Resonance Cholangiography in Living Donor Liver Transplantation

Transplantation Journal ◽

10.1097/tp.0b013e31821c1e33 ◽

2011 ◽

Vol 92 (1) ◽

pp. 94-99 ◽

Cited By ~ 15

Author(s):

Hsien-Wen Hsu ◽

Leo Leung-Chit Tsang ◽

Anthony Yap ◽

Tung-Liang Huang ◽

Tai-Yi Chen ◽

...

Keyword(s):

Liver Transplantation ◽

Magnetic Resonance ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Magnetic Resonance Cholangiography ◽

Donor Liver ◽

Donor Liver Transplantation

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A Lipidomics Study Reveals Lipid Signatures Associated with Early Allograft Dysfunction in Living Donor Liver Transplantation

Journal of Clinical Medicine ◽

10.3390/jcm8010030 ◽

2018 ◽

Vol 8 (1) ◽

pp. 30 ◽

Cited By ~ 6

Author(s):

Hsin-I Tsai ◽

Chi-Jen Lo ◽

Chih-Wen Zheng ◽

Chao-Wei Lee ◽

Wei-Chen Lee ◽

...

Keyword(s):

Liver Transplantation ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Graft Function ◽

Resonance Spectroscopy ◽

Donor Liver ◽

Donor Liver Transplantation ◽

Allograft Dysfunction ◽

Latent Structures ◽

Early Allograft Dysfunction

Liver transplantation has become the ultimate treatment for patients with end stage liver disease. However, early allograft dysfunction (EAD) has been associated with allograft loss or mortality after transplantation. We aim to utilize a metabolomic platform to identify novel biomarkers for more accurate correlation with EAD using blood samples collected from 51 recipients undergoing living donor liver transplantation (LDLT) by 1H-nuclear magnetic resonance spectroscopy (NMR) and liquid chromatography coupled with mass spectrometry (LC-MS). Principal component analysis (PCA) and orthogonal projection to latent structures-discriminant analysis (OPLS-DA) were used to search for a relationship between the metabolomic profiles and the presence of EAD.Cholesteryl esters (CEs), triacylglycerols (TGs), phosphatidylcholines (PCs) and lysophosphatidylcholine (lysoPC) were identified in association with EAD and a combination of cholesterol oleate, PC (16:0/16:0), and lysoPC (16:0) gave an optimal area under the curve (AUC) of 0.9487 and 0.7884 in the prediction of EAD and in-hospital mortality, respectively after LDLT. Such biomarkers may add as a potential clinical panel for the prediction of graft function and mortality after LDLT.

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