Cribriform-morular variant of papillary carcinoma: the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma. A case report with clinical and molecular genetic correlation

Pathology ◽  
2003 ◽  
Vol 35 (1) ◽  
pp. 42-46
Author(s):  
Siok Bian Ng ◽  
Kesavan Sittampalam ◽  
Yau Hong. Goh ◽  
Kong Weng Eu ◽  
Phillip L. Matson ◽  
...  
Keyword(s):  
Case Report ◽  
Familial Adenomatous Polyposis ◽  
Thyroid Carcinoma ◽  
Genetic Correlation ◽  
Papillary Carcinoma ◽  
Molecular Genetic ◽  
Adenomatous Polyposis ◽  
Cribriform Morular Variant ◽  
Sporadic Counterpart

scholarly journals Familial Adenomatous Polyposis—Rendering a Diagnosis Based on Recognition of an Unusual Primary Thyroid Neoplasm

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
David F. Schaeffer ◽  
Eric M. Yoshida ◽  
David A. Owen ◽  
Kenneth W. Berean
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Familial Adenomatous Polyposis ◽  
Thyroid Carcinoma ◽  
Clinical Features ◽  
Germline Mutations ◽  
Initial Diagnosis ◽  
Thyroid Neoplasm ◽  
Adenomatous Polyposis ◽  
Papillary Thyroid ◽  
Cribriform Morular Variant

It has been well established in the literature that the cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) has been observed with higher frequency in familial adenomatous polyposis (FAP) patients. In the usual setting, patients with FAP are identified based on their germline mutations and the diagnosis of thyroid neoplasm is made after the FAP diagnosis. We herein report a case in which the recognition of a CMVPTC led to the initial diagnosis of FAP. The histological and clinical features of CMVPTC are reviewed with emphasis on its relationship to FAP.

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