Serum Titanium Levels After Instrumented Spinal Arthrodesis

Spine ◽  
2008 ◽  
Vol 33 (7) ◽  
pp. 792-796 ◽  
Author(s):  
Travis D. Richardson ◽  
Stephen J. Pineda ◽  
K Brandon Strenge ◽  
Tim A. Van Fleet ◽  
Margaret MacGregor ◽  
...  
Keyword(s):  
Spinal Arthrodesis

The effects of dexamethasone on bone fusion in an experimental model of posterolateral lumbar spinal arthrodesis

2001 ◽  
Vol 94 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Paul D. Sawin ◽  
Curtis A. Dickman ◽  
Neil R. Crawford ◽  
M. Stephen Melton ◽  
William D. Bichard ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Bone Graft ◽  
Spinal Fusion ◽  
Experimental Model ◽  
Content Type ◽  
Bone Fusion ◽  
Group 12 ◽  
Spinal Arthrodesis ◽  
Lumbar Spinal ◽  
Fine Print

Object. The use of corticosteroid agents during the healing phase after spinal arthrodesis remains controversial. Although anecdotal opinion suggests that corticosteroids may inhibit bone fusion, such an effect has not been substantiated in clinical trials or laboratory investigations. This study was undertaken to delineate the effect of exogenous corticosteroid administration on bone graft incorporation in an experimental model of posterolateral lumbar fusion. Methods. An established, well-validated model of lumbar intertransverse process spinal fusion in the rabbit was used. Twenty-four adult New Zealand white rabbits underwent L5–6 bilateral posterolateral spinal fusion in which autogenous iliac crest bone graft was used. After surgery, the animals were randomized into two treatment groups: a control group (12 rabbits) that received intramuscular injections of normal saline twice daily and a dexamethasone group (12 rabbits) that received intramuscular dexamethasone (0.05 mg/kg) twice daily. After 42 days, the animals were killed and the integrity of the spinal fusions was assessed by radiography, manual palpation, and biomechanical testing. In seven (58%) of the 12 control rabbits, solid posterolateral fusion was achieved. In no dexamethasone-treated rabbits was successful fusion achieved (p = 0.003). Tensile strength and stiffness of excised spinal segments were significantly lower in dexamethasone-treated animals than in control animals (tensile strength 91.4 ± 30.6 N and 145.3 ± 48.2, respectively, p = 0.004; stiffness 31.4 ± 11.6 and 45.0 ± 15.2 N/mm, respectively, p = 0.02). Conclusions. The corticosteroid agent dexamethasone inhibited bone graft incorporation in a rabbit model of single-level posterolateral lumbar spinal fusion, inducing a significantly higher rate of nonunion, compared with that in saline-treated control animals.

Peptide Amphiphile Nanoslurry as an Improved BMP-2 Carrier for Spinal Arthrodesis

2016 ◽  
Vol 16 (10) ◽  
pp. S121
Author(s):  
Joseph A. Weiner ◽  
Ralph W. Cook ◽  
Danielle S. Chun ◽  
Mark McClendon ◽  
Sungsoo S. Lee ◽  
...  
Keyword(s):  
Peptide Amphiphile ◽  
Spinal Arthrodesis

Prior Lumbar Spinal Arthrodesis Increases Risk of Prosthetic-Related Complication in Total Hip Arthroplasty

2016 ◽  
Vol 31 (9) ◽  
pp. 227-232.e1 ◽  
Author(s):  
David C. Sing ◽  
Jeffrey J. Barry ◽  
Thomas U. Aguilar ◽  
Alexander A. Theologis ◽  
Joseph T. Patterson ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Related Complication ◽  
Total Hip ◽  
Spinal Arthrodesis ◽  
Lumbar Spinal

Bone Morphogenetic Proteins in Pediatric Spinal Arthrodesis

2017 ◽  
Vol 37 (6) ◽  
pp. e369-e374
Author(s):  
Benedict U. Nwachukwu ◽  
William W. Schairer ◽  
Ting Pan ◽  
Roger F. Widmann ◽  
John S. Blanco ◽  
...  
Keyword(s):  
Bone Morphogenetic Proteins ◽  
Spinal Arthrodesis

The Effect of Titanium Particulate on Development and Maintenance of a Posterolateral Spinal Arthrodesis

Spine ◽  
2002 ◽  
Vol 27 (18) ◽  
pp. 1971-1981 ◽  
Author(s):  
Bryan W. Cunningham ◽  
Carlos M. Orbegoso ◽  
Anton E. Dmitriev ◽  
Nadim J. Hallab ◽  
John C. Sefter ◽  
...  
Keyword(s):  
Spinal Arthrodesis

scholarly journals Spinal Biologics in Minimally Invasive Lumbar Surgery

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Kevin Y. Chang ◽  
Wellington K. Hsu
Keyword(s):  
Systematic Review ◽  
Minimally Invasive ◽  
Bone Graft ◽  
Lumbar Surgery ◽  
Spinal Arthrodesis ◽  
Optimal Fusion ◽  
Bone Graft Substitutes ◽  
Minimally Invasive Spine

As the use of minimally invasive spine (MIS) fusion approaches continues to grow, increased scrutiny is being placed on its outcomes and efficacies against traditional open fusion surgeries. While there are many factors that contribute to the success of achieving spinal arthrodesis, selecting the optimal fusion biologic remains a top priority. With an ever-expanding market of bone graft substitutes, it is important to evaluate each of their use as it pertains to MIS techniques. This review will summarize the important characteristics and properties of various spinal biologics used in minimally invasive lumbar surgeries and compare their fusion rates via a systematic review of published literature.

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