QUICKSCAN DICENTRIC CHROMOSOME ANALYSIS FOR RADIATION BIODOSIMETRY

2010 ◽  
Vol 98 (2) ◽  
pp. 276-281 ◽  
Author(s):  
F N. Flegal ◽  
Y Devantier ◽  
J P. McNamee ◽  
R C. Wilkins
Keyword(s):  
Chromosome Analysis ◽  
Dicentric Chromosome ◽  
Radiation Biodosimetry

Interlaboratory Comparison of the Dicentric Chromosome Assay for Radiation Biodosimetry in Mass Casualty Events

2008 ◽  
Vol 169 (5) ◽  
pp. 551-560 ◽  
Author(s):  
Ruth C. Wilkins ◽  
Horst Romm ◽  
Tzu-Cheg Kao ◽  
Akio A. Awa ◽  
Mitsuaki A. Yoshida ◽  
...  
Keyword(s):  
Interlaboratory Comparison ◽  
Mass Casualty ◽  
Dicentric Chromosome ◽  
Mass Casualty Events ◽  
Radiation Biodosimetry

scholarly journals Optimization and validation of automated dicentric chromosome analysis for radiological/nuclear triage applications

2019 ◽  
Vol 847 ◽  
pp. 503087 ◽  
Author(s):  
Terri L. Ryan ◽  
Maria B. Escalona ◽  
Tammy L. Smith ◽  
Joseph Albanese ◽  
Carol J. Iddins ◽  
...  
Keyword(s):  
Chromosome Analysis ◽  
Dicentric Chromosome

Laboratory Intercomparison of the Dicentric Chromosome Analysis Assay

2013 ◽  
Vol 180 (2) ◽  
pp. 129-137 ◽  
Author(s):  
C. Beinke ◽  
S. Barnard ◽  
H. Boulay-Greene ◽  
A. De Amicis ◽  
S. De Sanctis ◽  
...  
Keyword(s):  
Chromosome Analysis ◽  
Dicentric Chromosome ◽  
Laboratory Intercomparison

A comparison of estimates of doses to radiotherapy patients obtained with the dicentric chromosome analysis and the γ-H2AX assay: Relevance to radiation triage

2018 ◽  
Vol 131 ◽  
pp. 1-7 ◽  
Author(s):  
Bhavani Manivannan ◽  
Thayalan Kuppusamy ◽  
Srinivasan Venkatesan ◽  
Venkatachalam Perumal
Keyword(s):  
Chromosome Analysis ◽  
Dicentric Chromosome

Validation of QuickScan Dicentric Chromosome Analysis for High Throughput Radiation Biological Dosimetry

2012 ◽  
Vol 102 (2) ◽  
pp. 143-153 ◽  
Author(s):  
F. N. Flegal ◽  
Y. Devantier ◽  
L. Marro ◽  
R. C. Wilkins
Keyword(s):  
High Throughput ◽  
Chromosome Analysis ◽  
Dicentric Chromosome ◽  
Biological Dosimetry

scholarly journals Validation of the dicentric chromosome assay for radiation biological dosimetry in South Korea

2019 ◽  
Vol 60 (5) ◽  
pp. 555-563
Author(s):  
Younghyun Lee ◽  
Young Woo Jin ◽  
Ruth C Wilkins ◽  
Seongjae Jang
Keyword(s):  
South Korea ◽  
Irradiation Dose ◽  
Dicentric Chromosome ◽  
Medical Sciences ◽  
Radiation Accidents ◽  
Medical Response ◽  
Intercomparison Exercises ◽  
And Performance ◽  
Health Canada ◽  
Radiation Biodosimetry

Abstract The dicentric chromosome assay (DCA) is a well-established biodosimetry test to estimate exposure to ionizing radiation. The Korea Institute of Radiological and Medical Sciences (KIRAMS) established a DCA protocol as a medical response to radiation emergencies in South Korea. To maintain its accuracy and performance, intercomparison exercises with Health Canada (HC) have been conducted; herein, we aimed to validate our capacity of DCA analysis based on those results. Blood samples irradiated at HC were shipped to KIRAMS to assess the irradiation dose to blinded samples using conventional DCA full scoring and triage-based techniques (conventional DCA scoring in triage mode and DCA QuickScan method). Actual doses fell within the 95% confidence intervals of dose estimates for 70–100% of the blinded samples in 2015–2018. All methods discriminated binary dose categories, reflecting clinical significance. This DCA can be used as a reliable radiation biodosimetry tool in preparation for radiation accidents in South Korea.

Analysis of Gene Expression Changes in PHA-M Stimulated Lymphocytes – Unraveling PHA Activity as Prerequisite for Dicentric Chromosome Analysis

2018 ◽  
Vol 189 (6) ◽  
pp. 579 ◽  
Author(s):  
C. Beinke, ◽  
M. Port ◽  
R. Ullmann ◽  
K. Gilbertz ◽  
M. Majewski ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chromosome Analysis ◽  
Dicentric Chromosome
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