Pseudomonas aeruginosa Infection and Inflammation During Contact Lens Wear: A Review

2007 ◽  
Vol 84 (4) ◽  
pp. 273-278 ◽  
Author(s):  
MARK D. P. WILLCOX
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Contact Lens ◽  
Contact Lens Wear ◽  
Infection And Inflammation ◽  
Pseudomonas Aeruginosa Infection ◽  
Lens Wear

Contact Lens Wear Enhances Adherence of Pseudomonas aeruginosa and Binding of Lectins to the Cornea

Cornea ◽  
1990 ◽  
Vol 9 (3) ◽  
pp. 266???270 ◽  
Author(s):  
Stephen A. Klotz ◽  
Raghunath P. Misra ◽  
Salim I. Butrus
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Contact Lens ◽  
Contact Lens Wear ◽  
Lens Wear

The Development of an Antimicrobial Contact Lens – From the Laboratory to the Clinic

2020 ◽  
Vol 21 (4) ◽  
pp. 357-368 ◽  
Author(s):  
Mark D.P. Willcox ◽  
R. Chen ◽  
P. Kalaiselvan ◽  
M. Yasir ◽  
R. Rasul ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Contact Lens ◽  
Ocular Surface ◽  
Contact Lenses ◽  
Research Progress ◽  
Clinical Testing ◽  
Contact Lens Wear ◽  
Loss Of Vision ◽  
Infection And Inflammation ◽  
Lens Wear

Contact lens wear is generally safe and provides excellent vision. However, contact lens wear is often associated with the risk of developing ocular surface infection and inflammation, and in severe cases, the infection can result in loss of vision. Antimicrobial peptide-coated contact lenses have been made to help reduce the incidence of infection and inflammation. This paper reviews the research progress from conception, through the laboratory and preclinical tests to the latest information on clinical testing of an antimicrobial contact lens. We provide insights into the pathways followed and pitfalls that have been encountered. The journey has not always been linear or smooth, but has resulted in some of the first published clinical testing of antimicrobial peptide-coated contact lenses in humans. We hope this may help lead to the development and commercialisation of antimicrobial contact lenses in the future.

scholarly journals A novel murine model for contact lens wear reveals clandestine IL-1R dependent corneal parainflammation and susceptibility to microbial keratitis upon inoculation with Pseudomonas aeruginosa

2019 ◽  
Vol 17 (1) ◽  
pp. 119-133 ◽  
Author(s):  
Matteo M.E. Metruccio ◽  
Stephanie J. Wan ◽  
Hart Horneman ◽  
Abby R. Kroken ◽  
Aaron B. Sullivan ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Contact Lens ◽  
Murine Model ◽  
Microbial Keratitis ◽  
Contact Lens Wear ◽  
Lens Wear
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