The upper gastrointestinal (UGI) tract comprises of the oesophagus, stomach, and duodenum. Although some emergency management of UGI pathology may fall to the remit of the gastroenterologists, this chapter focuses specifically on surgical management of both benign and malignant pathology of these organs. UGI pathology contributes a significant amount to the on-call emergency workload for the general surgeon, as well as the UGI specialist. Subjects covered include the diagnosis and management of common pathologies in the upper gastrointestinal tract that are clinically relevant to those working in general surgery, including: gastro-oesophageal reflux (GORD) and ulcer disease, UGI bleeding, oesophagogastric cancer and bariatric surgery.