Chronic Lymphocytic Leukemia Associated with Myelodysplastic Syndrome with Ring Sideroblasts

2010 ◽  
Vol 103 (8) ◽  
pp. 823-827 ◽  
Author(s):  
Khalil M. Charafeddine ◽  
Georges Y. Ibrahim ◽  
Rami A. Mahfouz ◽  
Ghazi S. Zaatari ◽  
Ziad M. Salem
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Myelodysplastic Syndrome ◽  
Lymphocytic Leukemia ◽  
Ring Sideroblasts

scholarly journals Outcomes for patients with chronic lymphocytic leukemia and acute leukemia or myelodysplastic syndrome

Leukemia ◽  
2015 ◽  
Vol 30 (2) ◽  
pp. 325-330 ◽  
Author(s):  
F P Tambaro ◽  
G Garcia-Manero ◽  
S M O'Brien ◽  
S H Faderl ◽  
A Ferrajoli ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Acute Leukemia ◽  
Myelodysplastic Syndrome ◽  
Lymphocytic Leukemia

scholarly journals Donor-Cell Origin High-Risk Myelodysplastic Syndrome Synchronous with an Intracranial Meningioma-Like Tumor, 8 Years after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
G. Brás ◽  
C. Pinho-Vaz ◽  
A. Campos
Keyword(s):  
Stem Cell ◽  
High Risk ◽  
Chronic Lymphocytic Leukemia ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Myelodysplastic Syndrome ◽  
Cell Transplantation ◽  
Lymphocytic Leukemia ◽  
Hematopoietic Stem ◽  
Donor Cells

Secondary neoplasias are well known consequences of radiotherapy or chemotherapy for a primary cancer. In this report, we describe two rare secondary neoplasias occurring in the same patient: a meningioma-like intracranial tumor and high-risk myelodysplastic syndrome (MDS) of donor-cells origin, both diagnosed simultaneously, 8 years after an allogeneic hematopoietic stem cell transplantation (allo-HSCT) for chronic lymphocytic leukemia (CLL). Due to an engraftment failure during the first allo-HSCT of a matched related donor for CLL treatment, the salvage treatment was a second allo-HSCT. At the moment of meningioma-like tumor diagnosis, the patient was pancytopenic due to high-risk MDS, so it was decided to postpone a surgical intervention until hematological improvement. For the high-risk MDS of donor-cells origin the chosen treatment was induction with intensive chemotherapy. Due to refractory disease, the patient was treated with 5-azacitidine and donor-lymphocytes infusion with no response and, finally, a third allo-HSCT of a matched unrelated donor was performed. The patient died 6 months after the third allo-HSCT, in cytogenetic remission but without hematological recovery, due to an intracranial hemorrhage with origin in the meningioma-like tumor.

Overlapping deletion regions at 11q23 in myelodysplastic syndrome and chronic lymphocytic leukemia, characterized by a novel BAC probe set

2004 ◽  
Vol 153 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Ann Siew-Gek Lee ◽  
Christina Rudduck-Sivaswaren ◽  
Daniel Khun-Hong Lie ◽  
Constance Li-Ming Chua ◽  
Sim-Leng Tien ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Myelodysplastic Syndrome ◽  
Lymphocytic Leukemia ◽  
Probe Set

Concurrent diagnosis of chronic lymphocytic leukemia and myelodysplastic syndrome

1997 ◽  
Vol 21 (7) ◽  
pp. 619-621 ◽  
Author(s):  
Linda S. Sylvester ◽  
Peter C. Nowell ◽  
Hugh Bonner ◽  
Lisa Moreau ◽  
Jonni S. Moore
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Myelodysplastic Syndrome ◽  
Lymphocytic Leukemia
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