Clinico-Biomechanical Issues and Dynamic Stabilization When Considering Stem Cell Treatment for Degenerative Disc Disease

2013 ◽  
Vol 95 (2) ◽  
pp. e1
Author(s):  
Javier Melchor Duart Clemente ◽  
Julio Vicente Duart Clemente
Keyword(s):  
Stem Cell ◽  
Degenerative Disc Disease ◽  
Dynamic Stabilization ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Stem Cell Treatment

scholarly journals Posterior Transpedicular Dynamic Stabilization versus Total Disc Replacement in the Treatment of Lumbar Painful Degenerative Disc Disease: A Comparison of Clinical Results

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Tunc Oktenoglu ◽  
Ali Fahir Ozer ◽  
Mehdi Sasani ◽  
Yaprak Ataker ◽  
Cengiz Gomleksiz ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Total Disc Replacement ◽  
Clinical Results ◽  
Dynamic Stabilization ◽  
Disc Replacement ◽  
Disc Prosthesis ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Duration Of Surgery ◽  
The Mean

Study Design. Prospective clinical study.Objective. This study compares the clinical results of anterior lumbar total disc replacement and posterior transpedicular dynamic stabilization in the treatment of degenerative disc disease.Summary and Background Data. Over the last two decades, both techniques have emerged as alternative treatment options to fusion surgery.Methods. This study was conducted between 2004 and 2010 with a total of 50 patients (25 in each group). The mean age of the patients in total disc prosthesis group was 37,32 years. The mean age of the patients in posterior dynamic transpedicular stabilization was 43,08. Clinical (VAS and Oswestry) and radiological evaluations (lumbar lordosis and segmental lordosis angles) of the patients were carried out prior to the operation and 3, 12, and 24 months after the operation. We compared the average duration of surgery, blood loss during the surgery and the length of hospital stay of both groups.Results. Both techniques offered significant improvements in clinical parameters. There was no significant change in radiologic evaluations after the surgery for both techniques.Conclusion. Both dynamic systems provided spine stability. However, the posterior dynamic system had a slight advantage over anterior disc prosthesis because of its convenient application and fewer possible complications.

scholarly journals A comparative study of mesenchymal stem cell transplantation and NTG-101 molecular therapy to treat degenerative disc disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ajay Matta ◽  
Muhammad Zia Karim ◽  
Hoda Gerami ◽  
Bettina Benigno ◽  
W. Mark Erwin
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Degenerative Disc Disease ◽  
Molecular Therapy ◽  
Disc Disease ◽  
Mesenchymal Stem Cell Transplantation ◽  
Degenerative Disc

AbstractCellular replacement therapy using mesenchymal stem cells (MSCs) and/or the delivery of growth factors are at the forefront of minimally invasive biological treatment options for Degenerative Disc Disease (DDD). In this study, we compared the therapeutic potential of a novel drug candidate, NTG-101 to MSCs, including rat cartilage derived stem cells (rCDSCs), bone marrow stem cells (rBMSCs) and human Umbilical Cord Derived Mesenchymal Stem Cells (hUCMSCs) for the treatment of DDD. We induced DDD using a validated image-guided needle puncture injury in rat-tail IVDs. Ten weeks post-injury, animals were randomized and injected with MSCs, NTG-101 or vehicle. At the end of the study, histological analysis of the IVD-Nucleus Pulposus (NPs) injected with NTG-101 or rCDSCs showed a healthy or mild degenerative phenotype in comparison to vehicle controls. Immunohistochemical analysis revealed strong expression of aggrecan, collagen 2, brachyury and Oct4 in IVD-NPs injected with NTG-101. Our results also demonstrated suppression of inflammation induced p38 and NFκB resulting in inhibition of catabolic genes, but activation of Smad-2/3, Erk-1/2 and Akt-dependent signaling inducing anabolic genes in IVD-NP on treatment with NTG-101. In conclusion, a single injection of NTG-101 into the degenerative disc demonstrated superior benefits compared to stem cell transplantation.

scholarly journals Stem-cell treatment in disc degeneration: What is the evidence?

2013 ◽  
Vol 12 (1) ◽  
pp. 61-63
Author(s):  
Manuela Peletti-Figueiró ◽  
Pedro Guarise da Silva ◽  
Olívia Egger de Souza ◽  
Ana Paula Lambert ◽  
Denise Cantarelli Machado ◽  
...  
Keyword(s):  
Stem Cells ◽  
Degenerative Disc Disease ◽  
Clinical Studies ◽  
Potential Role ◽  
Experimental Studies ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Stem Cell Treatment

To review the potential role of stem cells in treating degenerative disc disease of the intervertebral disc (IVD). A review was performed of articles from the Medline database concerning stem cells and degenerative disc disease (DDD). To discuss the data, the papers were classified as: review, in vitro, experimental, and clinical. The currently available treatments were basically for symptom reduction, not to revert the IVD degenerative process. The use of mesenchymal stem cells (MSC) is being proposed as an option of treatment for DDD. In vitro studies have shown that the MSC are able to differentiate into NP cells and that the MSC also reduce the inflammatory levels of the degenerated IVD. Besides, experimental studies demonstrated that the MSC remained viable when injected into the IVD, and that they were able to regenerate partially from the degenerated IVD and its structure. The few clinical studies found in the literature presented diverging results. The use of MSC is being widely studied and shows promising results for the treatment of DDD. Although many advances are being achieved in studies in vitro and experimental, there is a lack of clinical studies to prove the role of MSC in DDD management.

Sign in / Sign up

Export Citation Format

Share Document