scholarly journals Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model after infection with a bovine adenovirus type 3 recombinant virus expressing the firefly luciferase gene

1996 ◽  
Vol 77 (1) ◽  
pp. 1-9 ◽  
Author(s):  
S. K. Mittal ◽  
D. M. Middleton ◽  
S. K. Tikoo ◽  
L. Prevec ◽  
F. L. Graham ◽  
...  
Virology ◽  
1995 ◽  
Vol 213 (1) ◽  
pp. 131-139 ◽  
Author(s):  
Suresh K. Mittal ◽  
Dorothy M. Middleton ◽  
Suresh K. Tikoo ◽  
Lorne A. Babiuk

Virology ◽  
2001 ◽  
Vol 290 (1) ◽  
pp. 153-163 ◽  
Author(s):  
Mohit K. Baxi ◽  
Jill Robertson ◽  
Lorne A. Babiuk ◽  
Suresh K. Tikoo

2002 ◽  
Vol 83 (6) ◽  
pp. 1311-1314 ◽  
Author(s):  
Hendrik J. Rademaker ◽  
Mohamed A. Abou El Hassan ◽  
Gijs A. Versteeg ◽  
Martijn J. W. E. Rabelink ◽  
Rob C. Hoeben

Mobilization of replication-deficient adenovirus vectors can lead to spread and shedding of the vector. Here we show that in cultured HepG2 cells wild-type (wt) adenoviruses of subgroup A (Ad12), B (Ad7, 11 and 16), C (Ad1, 2 and 5) and E (Ad4) can efficiently mobilize Ad5CMVluc, a ΔE1ΔE3-Ad5 vector carrying the firefly luciferase gene as reporter. In addition, we show that Ad5CMVluc can be propagated on Ad12E1-transformed human embryonic retinoblasts. This provides evidence that expression of the E1 region of Ad12 is sufficient for mobilizing ΔE1-Ad5-derived vectors. Thus, in therapeutic applications of replication-defective Ad vectors any active Ad infection is of potential concern, independent of the serotype involved. To prevent vector mobilization by wt Ads, new vectors should be developed in which essential functions such as the initiation of DNA replication and genome packaging are restricted.


1995 ◽  
Vol 76 (1) ◽  
pp. 93-102 ◽  
Author(s):  
S. K. Mittal ◽  
L. Prevec ◽  
F. L. Graham ◽  
L. A. Babiuk

Nature ◽  
1966 ◽  
Vol 211 (5044) ◽  
pp. 102-102 ◽  
Author(s):  
J. H. DARBYSHIRE

Virology ◽  
2014 ◽  
Vol 450-451 ◽  
pp. 174-181 ◽  
Author(s):  
Lingpeng Cheng ◽  
Xiaoxing Huang ◽  
Xiaomin Li ◽  
Wei Xiong ◽  
Wei Sun ◽  
...  

Virology ◽  
2002 ◽  
Vol 295 (1) ◽  
pp. 108-118 ◽  
Author(s):  
Alberto L. van Olphen ◽  
Suresh K. Tikoo ◽  
Suresh K. Mittal

1975 ◽  
Vol 16 (3) ◽  
pp. 634-641 ◽  
Author(s):  
K Igarashi ◽  
Y Niiyama ◽  
K Tsukamoto ◽  
T Kurokawa ◽  
Y Sugino

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