scholarly journals Transplantation: Polyomavirus Nephropathy and the Risk of Specific Immunosuppression Regimens

2006 ◽  
Vol 6 ◽  
pp. 412-528 ◽  
Author(s):  
Christine Wu ◽  
Parmjeet Randhawa ◽  
Jerry McCauley
Keyword(s):  
Risk Factors ◽  
Renal Transplant ◽  
Kidney Transplant ◽  
Transplant Patient ◽  
Graft Loss ◽  
Bk Virus ◽  
Therapeutic Monitoring ◽  
Kidney Transplant Patient ◽  
Bk Polyomavirus ◽  
Specific Immunosuppression

BK virus is ubiquitously present in the latent state in humans, and awareness of the importance of BK polyomavirus is emerging among the kidney transplant community. First discovered in 1971 in the urine of a renal transplant recipient, BK virus nephropathy (BKVN) has come to be recognized as a significant cause of genitourinary disease and potential graft loss in the kidney transplant patient. In this review, we discuss the risk factors, available methods of diagnosis and therapeutic monitoring, and current approaches to therapy of BKVN.

Human BK Polyomavirus Nephropathy (BKVN) In Non- Kidney-Transplant Patients

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S118-S118
Author(s):  
Y Chen Wongworawat ◽  
C Zuppan
Keyword(s):  
Renal Transplant ◽  
Kidney Transplant ◽  
Graft Loss ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Transplant Patients ◽  
Bk Polyomavirus ◽  
Pathologic Features ◽  
Renal Biopsies ◽  
Renal Transplant Patients

Abstract Introduction/Objective Human BK polyomavirus nephropathy (BKVN) occurs in up to 10% of renal transplant recipients, and can result in graft loss. Transplant biopsy is the gold standard to diagnose BKVN, and SV40 immunohistochemical (IHC) staining is helpful in confirming the diagnosis. BKVN is uncommon outside the setting of renal transplantation. To understand more about its occurrence in other contexts, we reviewed our renal biopsies files for cases of BKVN. Methods Our renal biopsy files for the past 20 years were reviewed for all cases with a diagnosis of BKVN or polyoma virus infection, and the clinical characteristics of the affected patients noted. Results Evidence of BKVN was found in 44 renal biopsies, of which 39 (86%) were renal transplant patients. Of the remaining five patients (14%), two had undergone heart transplantation, one lung transplantation, one was undergoing chemotherapy for acute lymphoblastic leukemia, and one patient had active HIV infection. All patients had elevated serum creatinine, and four out of five patients had documented BK viremia. Four of the five biopsies showed typical tubular injury with viral nuclear cytopathic changes (inclusions). In the lung transplant patient, the biopsy showed advanced chronic tubulointerstitial injury without distinct viral inclusions, but SV40 staining confirmed the presence of BK virus antigen. Conclusion The BKVN is distinctly uncommon outside the context of kidney transplantation. In our series, 14% of patients with BKVN were not kidney transplant recipients, but all were immune compromised in some fashion. The pathologic features of BKVN appear similar, regardless of whether the host is a renal transplant recipient or not. Although uncommon, it is important to consider the possibility of BKVN in non-renal transplant patients with persistent or progressive renal dysfunction.

scholarly journals Successful Treatment of BK Virus-Associated Hemorrhagic Cystitis in a Kidney Transplant Patient: a Case Report

2015 ◽  
Vol 89 (6) ◽  
pp. 704-708
Author(s):  
Sihyung Park ◽  
Ga Hee Lee ◽  
Bong Soo Park ◽  
Kubok Jin ◽  
Jin Han Park ◽  
...  
Keyword(s):  
Case Report ◽  
Kidney Transplant ◽  
Successful Treatment ◽  
Transplant Patient ◽  
Hemorrhagic Cystitis ◽  
Bk Virus ◽  
Kidney Transplant Patient

scholarly journals Parvovirus: Uncommon Causes of Anemia and Kidney Failure in a Kidney Transplant Patient

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Maliheh Yarmohamadi ◽  
Fatemeh Yaghoubi
Keyword(s):  
Kidney Transplantation ◽  
Renal Transplant ◽  
Kidney Transplant ◽  
Kidney Failure ◽  
Graft Failure ◽  
Transplant Patient ◽  
Parvovirus B19 ◽  
Kidney Transplant Patient ◽  
Severe Anemia ◽  
Parvovirus B19 Infection

: Parvovirus is one of the uncommon causes of anemia in a kidney transplant patient. We reported a kidney transplant patient with parvovirus infection who developed severe anemia three weeks after kidney transplantation. Suspicion of infections increased due to the decrease in erythrocyte level. The patient's anemia became normal with a decrease in the amount of immunosuppressant and treatment with intravenous immunoglobulin (IVIG). Parvovirus B19 infection should be considered in all patients with persistent anemia with or without graft failure after renal transplant.

BK Virus in the Kidney Transplant Patient

2013 ◽  
Vol 345 (6) ◽  
pp. 482-488 ◽  
Author(s):  
Sarat Kuppachi ◽  
Beje Thomas ◽  
Kenneth E. Kokko
Keyword(s):  
Kidney Transplant ◽  
Transplant Patient ◽  
Bk Virus ◽  
Kidney Transplant Patient

Graft Loss in a Living Kidney Transplant Patient with Munchausen Syndrome

2011 ◽  
Vol 52 (4) ◽  
pp. 394-395 ◽  
Author(s):  
Katsuji Nishimura ◽  
Hidehiro Oshibuchi ◽  
Sayaka Kobayashi ◽  
Hiroko Sugawara ◽  
Akihito Sannomiya ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Transplant Patient ◽  
Graft Loss ◽  
Kidney Transplant Patient ◽  
Munchausen Syndrome

Successful Treatment for BK Virus Nephropathy by Leflunomide in a Kidney Transplant Patient: A Case Report

2019 ◽  
Vol 51 (5) ◽  
pp. 1472-1474 ◽  
Author(s):  
Mei-Yi Wu ◽  
Yu-Wei Chen ◽  
Lie-Yee Hung ◽  
Chii-Hong Lee ◽  
Hsin-An Chen ◽  
...  
Keyword(s):  
Case Report ◽  
Kidney Transplant ◽  
Successful Treatment ◽  
Transplant Patient ◽  
Bk Virus ◽  
Kidney Transplant Patient ◽  
Bk Virus Nephropathy

scholarly journals BK Polyomavirus Micro-RNAs: Time Course and Clinical Relevance in Kidney Transplant Recipients

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 351
Author(s):  
Baptiste Demey ◽  
Véronique Descamps ◽  
Claire Presne ◽  
Francois Helle ◽  
Catherine Francois ◽  
...  
Keyword(s):  
Viral Replication ◽  
Kidney Transplant ◽  
Clinical Relevance ◽  
Graft Loss ◽  
First Year ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Post Transplantation ◽  
Bk Polyomavirus ◽  
Micro Rnas

Background: Kidney transplant recipients (KTRs) are exposed to a high risk of BK polyomavirus (BKPyV) replication, which in turn may lead to graft loss. Although the microRNAs (miRNAs) bkv-miR-B1-3p and bkv-miR-B1-5p are produced during the viral cycle, their putative value as markers of viral replication has yet to be established. In KTRs, the clinical relevance of the changes over time in BKPyV miRNA levels has not been determined. Methods: In a retrospective study, we analyzed 186 urine samples and 120 plasma samples collected from 67 KTRs during the first year post-transplantation. Using a reproducible, standardized, quantitative RT-PCR assay, we measured the levels of bkv-miR-B1-3p and bkv-miR-B1-5p (relative to the BKPyV DNA load). Results: Detection of the two miRNAs had low diagnostic value for identifying patients with DNAemia or for predicting DNAuria during follow-up. Seven of the 14 KTRs with a sustained BKPyV infection within the first year post-transplantation showed a progressive reduction in the DNA load and then a rapid disappearance of the miRNAs. DNA and miRNA loads were stable in the other seven KTRs. Conclusions: After the DNA-based diagnosis of BKPyV infection in KTRs, bkv-miR-B1-3p and bkv-miR-B1-5p levels in the urine might be valuable markers for viral replication monitoring and thus might help physicians to avoid an excessive reduction in the immunosuppressive regimen.

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